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CombiFlash
Companion
Table 9-1 Suggested Flow Cell Cleaning Solvents
Solvent
Methanol
Acetone
Dichloromethane
(DCM)
Dimethylsulfoxide
(DMSO)
Dimethylformamide
(DMF)
Tetrahydrofuran
(THF)
Mildly acidic
aqueous solution
Mildly basic
aqueous solution
a. Always handle solvents in accordance with the manufacturer's or
supplier's MSDS.
9-4
®
XL Installation Guide
Description
Miscible with most LC solvents. It will force other
solvents through the system so that they will not
interfere with the next sample. Breaks down the
tertiary structure of silica and allows it to flush
through.
Common organic solvent with high dissolving
properties.
Effective at solubilizing organic molecules.
Strong solvent that will clear organic sample.
Strong solvent if other solvents do not produce
the desired results.
Strong solvent.
0.5M acetic acid in distilled water can be used to
clear samples that are not removed by organic
solvents.
A dish-type detergent solution can wash through
particulates not picked up by the acidic solution.
The emulsification effect of detergent is an
effective tool as well to help wash through oily
samples. Follow the detergent with several
minutes of clean, distilled water.
a
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