Agilent Technologies 1260 Infinity II User Manual page 53

Solvent Recommendation for Agilent 1290 Infinity and 1290 Infinity II and 1260 Infinity II Flexible Pumps
To avoid changing to the Type N valves when running critical solvents, it is
possible to increase the conductivity, by adding 5 % of a miscible, polar
solvent, in general isopropanol is a good choice. Due to its unique properties,
Tetrahydrofuran (THF) may lead to fast degeneration of internal pump parts
resulting in very early part failures on Agilent 1290 Infinity and 1290 Infinity
II pumps.
These and other uncommon LC solvents might work well when diluted to
lower concentrations or when used for short time periods only.
Choice of Normal Phase Valves
While the 1290 Pumps are well suited for running a variety of application with
normal phase columns in the delivered configuration, exclusively running
solvents with small dielectric constant requires a change of the valves. The
Normal phase valves (Type N valves) have a design based on the existing 1290
Infinity valves with a conductive ceramic seat and non-conductive ruby balls.
The ball inside these valves are made from conductive material which does not
charge up electrostatically and reduces particle accumulation in the check
valves.
Table 4
Inlet valves
Outlet valves
These Type N valves are not suitable for use with acidic, acid containing, or
aqueous solvents which would rapidly lead to a corrosive destruction of the
valves. This is also the reason why these valves should only be used in systems
where only solvents with a small dielectric constant are used.
Corrosion of valves
C AU T I O N
Normal phase balls/valves corrode quickly in aqueous solutions and acids (at or
below pH 7).
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1260 Infinity II Flexible Pump User Manual
Recommended valves for normal phase applications
Do not use normal phase valves in applications running with aqueous solutions.
Binary or High Speed Pumps
1290 Infinity Inlet Valve Type
N (G4220-60122)
1290 Infinity Outlet Valve Type
N (G4220-60128)
Using the Module
Quaternary or Flexible Pumps
1290 Infinity Quat Inlet Valve
Type N (G4204-60122)
1290 Infinity Outlet Valve Type
N (G4220-60128)
3
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