Chapter 4 Daily Operation - Thermo Scientific LTQ Series Hardware Manual

Daily Operation
Thermo Scientific
To ensure the proper operation of the LTQ Series system, Thermo Fisher Scientific
recommends that you perform daily preventive maintenance. This chapter specifies the items
to check before operating the system and the cleaning procedures to perform after completing
the analyses.
Note You do not need to tune (optimize the tune parameters for the ESI calibration
solution) and calibrate the LTQ Series system as part of your daily routine.
Generally, calibration parameters are instrument parameters that affect the mass accuracy
and resolution. Tune parameters are instrument parameters that affect the intensity of the
ion signal. You calibrate the LTQ Series system by using the ESI calibration solution about
once every month. Do some calibrations, such as for the electron multiplier gain, more
often.
You should check the optimization of the tune parameters (create a new tune method)
whenever you change the type of experiment, the specific compound, or the compound
class.
Pump down times of less than 15 hours on new instruments or after venting the mass
spectrometer might cause incorrect calibration and might increase the aging of the
electron multipliers.
For information about tuning and calibration, refer to the LTQ Series Getting Started
Guide.
Contents
• Before Operating the LTQ Series System
• After Operating the LTQ Series System
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