Baseline Noise; Data Collection Rate - Thermo Scientific Corona Veo Operating Manual

6 • Operation
Guidelines for selecting a power function value
6.7.7

Baseline Noise

6.7.8

Data Collection Rate

Page 146
To optimize the power function value, observe the following guidelines:
•
An optimal power function value improves the linearity of response
over a given range of interest.
•
Selecting the optimal value depends primarily on the analysis
conditions and the desired range of quantitation.
Baseline noise can originate from many factors. To minimize the
baseline noise, observe the following:
•
The quality of the mobile phase has a major impact on the
performance of the detector. Only use mobile phases of the highest
quality available. Keep impurities and contaminants to a minimum.
Follow the Mobile Phase Guidelines for the Detector in section 6.5.1,
page 123.
•
Flush the system modules at regular intervals to remove any non-
volatile residues, if applicable.
•
Follow the maintenance schedules to keep the system modules in
optimum performance state.
•
Keep the supplied gas in optimum quality for the detector. Observe
the gas supply requirements in
•
Fluctuations in pump backpressure can cause baseline noise. If the
noise is synchronized with the pump stroke, check your HPLC pump.
When you operate the detector from a chromatography data system,
you can select the digital data collection rate in order to optimize the
performance of the detector.
The data collection rate is the number of data points per second (Hz)
that the chromatography software collects from the detector and stores
as raw data.
Charged Aerosol Detectors Corona Veo (RS) Operating Manual
section 5.3.7, page 61.