Operating Principle - Thermo Scientific Corona Veo Operating Manual

3.2

Operating Principle

Charged Aerosol Detectors Corona Veo (RS) Operating Manual
The detector is designed for charged aerosol detection with full
compatibility in HPLC and UHPLC applications. In charged aerosol
detection, an aerosol of dried analyte particles is formed after
nebulization of column eluate. Electrical charge is imparted to these
dried particles. The detector then measures the charge. Measured
charge is proportional to the amount of analyte in the sample.
The following picture shows the interior components of the detector,
and illustrates how the detector operates:
Figure 1: Operating principle of the detector
No. Description
1 Mobile phase from column
2 Nebulizer
3 Gas inlet
4 Gas filters
5 Spray chamber
6 Drain pump
7 Evaporation tube
Mobile phase from the column enters the detector (no. 1) and flows to
the nebulizer (no. 2). Pressurized gas streams through the gas inlet
(no. 3) and passes through the charcoal gas filter and then the HEPA gas
filter (no. 4). In the nebulizer (no. 2), the filtered gas and the mobile
3 • Detector Overview
No. Description
8 Mixing chamber
9 Charger gas inlet
10 Corona charger
11 Ion trap
12 Electrometer
13 Electrometer board
14 Gas exhaust
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