Routine And Preventive Maintenance; Maintenance Plan; Cleaning Or Decontaminating The System - Thermo Scientific thermoscientific Vanquish UHPLC System Operating Manual

7 • Maintenance and Service
7.4

Routine and Preventive Maintenance

7.4.1

Maintenance Plan

7.4.2

Cleaning or Decontaminating the System

Page 106
Optimum system performance, maximum uptime of the system, and
accurate results can be obtained only if the system is in good condition
and properly maintained.
Perform the maintenance procedures in the table on a regular basis. The
frequency given in the table is a suggestion. The optimum frequency for
maintenance depends on several factors, such as the types and amounts
of samples and solvents used with the system.
Frequency
Daily
Regularly
Annually
Cleaning and decontamination must be performed by qualified
personnel wearing suitable personal protective equipment. Always
observe national and local regulations.
What you should do...
• Inspect the flow connections for signs of leakage or
blockage.
• When you use buffers or salt solutions, flush the system
thoroughly after use with an appropriate solvent that
does not contain buffers or salts.
• Solvent line filter frits: regularly check the filter frits for
permeability. Replace the filter frits at regular intervals.
This is especially important when using aqueous solvents.
Aqueous solvents may contaminate the filters with algae
and other microorganisms that deposit on the filter frits.
Therefore, also replace the solvents at regular intervals.
Rinse the reservoirs thoroughly before refilling them.
• Empty the waste container or containers.
• Inspect the flow connections for damage, such as cracks,
nicks, cuts, or blockage.
• Check the drain system for blockage (see
Drain System (} page 74)). If a leak alarm is triggered or if
a leak is visible, find and eliminate the blockage.
• Clean the system (see Cleaning or Decontaminating the
System (} page 106)).
• Check that all warning labels are still present on the
system and clearly legible. If they are not, contact
Thermo Fisher Scientific for replacement.
Have Thermo Fisher Scientific service personnel perform
preventive maintenance once a year.
Testing the
UHPLC System
Operating Manual