2
•
Safety
2.4.2
Allowed pH Ranges
2.4.3
Allowed Concentrations
Page 26
Allowed pH ranges (standard system configuration):
System
Allowed
(Standard
pH ranges
Configuration)
Vanquish Core
1-13
Vanquish
2-12
Horizon
Vanquish Flex
Allowed concentrations (standard system configuration):
System
Chloride
(Standard
Configuration)
Vanquish Core
0.1 mol/L
or less
Vanquish Horizon
1 mol/L or
less
Vanquish Flex
Remarks
•
pH values of 2 or less: The application time should
be as short as possible. Flush the system
thoroughly after these applications.
•
pH values higher than 9.5 with optical detectors:
Avoid using mobile phases with a pH value higher
than 9.5 together with optical detectors. This can
impair the functionality and optical performance
of the detector flow cell.
•
pH values higher than 12: May affect
electrochemical detection. Before using highly
alkaline solvents for flushing the system,
disconnect the detector from the system.
•
Mobile phases containing ammonium hydroxide: In
rare cases, a shortened lifetime of reversed-phase
(UHMW-PE) piston seals has been observed with
high pH, ammonium hydroxide containing mobile
phases and prolonged exposure.
Buffer
Remarks
1 mol/L or
•
High chloride concentration:
less
The application time should be
as short as possible. Flush the
-
system thoroughly after these
applications.
•
Mobile phases containing
ammonium hydroxide: In rare
cases, a shortened lifetime of
reversed-phase (UHMW-PE)
piston seals has been observed
with high pH, ammonium
hydroxide containing mobile
phases and prolonged
exposure.
UHPLC System
Operating Manual