Solvent Information - Agilent Technologies 1200 Series Reference Manual

Solvent Information

Always filter solvents through 0.4 µm filters, small particles can permanently
block the capillaries and valves. Avoid the use of the following steel-corrosive
solvents:
• Solutions of alkali halides and their respective acids (for example, lithium
• High concentrations of inorganic acids like sulfuric acid, especially at
• Halogenated solvents or mixtures which form radicals and/or acids, for
• Chromatographic grade ethers, which can contain peroxides (for example,
• Mixtures of carbon tetrachloride with 2-propanol or THF dissolve stainless
1200 Series QP Reference Manual
iodide, potassium chloride, and so on).
higher temperatures (replace, if your chromatography method allows, by
phosphoric acid or phosphate buffer which are less corrosive against
stainless steel).
example:
→
2CHCl + O 2COCl
3 2
This reaction, in which stainless steel probably acts as a catalyst, occurs
quickly with dried chloroform if the drying process removes the stabilizing
alcohol.
THF, dioxane, di-isopropylether) such ethers should be filtered through dry
aluminium oxide which adsorbs the peroxides.
steel.
+ 2HCl
2
Optimizing Performance 2
33