Agilent Technologies Infinity II SFC Binary 1260 User Manual page 61

compressibility values accordingly. Compressibility settings can be optimized
by using the values for various solvents described in
solvent in use is not listed in the compressibility table, when using premixed
solvents and if the default settings are not sufficient for your application, the
following procedure can be used to optimize the compressibility settings:
1 Start channel A of the binary pump with the required flow rate.
2 Before starting the optimization procedure, the flow must be stable. Use
3 Your pump must be connected to an Agilent data system or Instant Pilot,
4 Start the recording device in plot mode.
5 Starting with a compressibility setting of 40 × 10
6 Repeat step 1 through step 5 for the B channel of your binary pump.
Table 8
Solvent (pure)
Acetone
Acetonitrile
Benzene
Carbon tetrachloride
Chloroform
Cyclohexane
Ethanol
Ethyl acetate
Heptane
Hexane
Isobutanol
Isopropanol
1260 SFC Binary Pump
How to Optimize the Compressibility Compensation Setting
degassed solvent only. Check the tightness of the system with the pressure
test (see ).
the pressure- and %-ripple can be monitored with one of these instruments.
in steps of 10. The compressibility compensation setting that generates the
smallest pressure ripple is the optimum value for your solvent composition.
Solvent Compressibility
-6
Compressibility (10 /bar)
126
115
95
110
100
118
114
104
120
150
100
100
Optimizing Performance
Table 8 on page 61. If the
-6
/bar, increase the value
4
61