The Acquity Refractive Index Detector - Waters ACQUITY Refractive Index Detector Overview And Maintenance Manual

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The ACQUITY Refractive Index
Detector
The ACQUITY refractive index detector is designed for
ultra-performance liquid chromatography and advanced polymer
chromatography applications. It operates as a component of Waters
ACQUITY
Refer to
solvent considerations.
The major advantage of refractive index detectors lies in the universal
nature of their response. They are well-suited to analyze compounds
that are without strong UV chromophores, fluorophores, or
electrochemical or ionic activity. Refractive index (RI) detectors are used
to analyze carbohydrates, lipids, and polymers.
RI detectors work by measuring changes in the bulk properties of the
solvent and the solutes under investigation, exploiting the improbability
that solvents and solutes would share the identical refractive index.
RI detection is inherently less sensitive than other detection methods. It
is not suitable to gradient analyses, and changes in solvent temperature
and pressure can cause baseline instability. Also, the possibility exists
that positive or negative peaks can appear during a single analysis.
®
systems.
Appendix B, for system specifications, and to
October 13, 2014, 715003547 Rev. C
Chapter 2, for
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