Accumetrics VerifyNow User Manual page 114

Term Description
Percent Percent inhibition (%) is the percent change from baseline
inhibition aggregation, and is calculated from a result and a base or
baseline result.
PGE1 The VerifyNow P2Y12 assay uses PGE1 to increase intraplatelet
cAMP and reduce the contribution of the P2Y1 receptor on
activation. This makes the assay more specific for the effects of
ADP on the P2Y12 receptor.
Platelet Also called a thrombocyte. A discoid cell found in large numbers
in blood, responsible for aggregation and contributing to
haemostasis by repairing vascular wall injuries.
Platelet Platelet activation induces a conformational change in the platelet
activation glycoprotein IIb/IIIa receptors on the surface of platelets to an
activated high-affinity binding site for fibrinogen and vWF. The
platelet changes from a disc shape to a round shape with long,
filopodial extensions that can bind to adhesive proteins in
circulation, such as fibrinogen, to form a meshwork of platelets.
Platelet The IIb/IIIa assay reports patient results in Platelet Aggregation
aggregation Units (PAU). PAU is calculated as a function of the rate and
units extent of aggregation.
Platelet function A laboratory or point-of-care test to measure platelet activity or
test platelet inhibition in patients. One method detects platelet activity
by measuring in vitro platelet aggregation in a blood sample
exposed to specific agonists.
Platelet The condition in which or the process by which platelet
inhibition aggregation is inhibited. Platelet inhibition may be induced in
response to a potent anti-platelet agent (e.g. acetylsalicylic acid
(aspirin), P2Y12 inhibitors, and GP IIb/IIIa inhibitors).
Plavix Clopidogrel (trade name Plavix
oral antiplatelet agent used in the treatment of coronary artery
disease, peripheral vascular disease, and cerebrovascular
disease. As a thienopyridine, its mechanism of action is inhibition
of the P2Y12 receptor.
Pouch The white assay device package.
Power indicator When power is on, a green LED indicator on the lower left corner
of the keypad remains illuminated.
VerifyNow System User Manual
®
- clopidogrel bisulfate) is a potent
Page 114
APPENDIX - 11
14340.J