Accumetrics VerifyNow User Manual page 113

Term Description
P2Y12 reaction PRU. PRU reports the amount of ADP-mediated aggregation
units specific to the platelet P2Y12 receptor, and is calculated as a
function of the rate and extent of platelet aggregation in the ADP
channel.
P2Y12 receptor The P2Y12 receptor is a G protein-coupled P2 receptor on the
surface of the platelet. Adenosine diphosphate (ADP) secreted
from activated platelets results in the further amplification by
activating additional platelets in circulation via the P2Y1 and
P2Y12 receptors.
PAR-1 receptor PAR-1 is one of four protease-activated receptors (PAR) located
on the surface of platelets. Thrombin activates PAR-1 by cleavage
of part of its extracellular domain. Thrombin receptor activating
peptide (iso-TRAP), a synthetic peptide, serves as a surrogate for
thrombin and activates the platelet through the PAR-1 receptor in
the P2Y12 and IIb/IIIa assays.
PAR-4 receptor PAR-4 is one of four protease-activated receptors (PAR) located
on the surface of platelets. Thrombin activates PAR-4 by cleavage
of part of its extracellular domain. PAR-4 activating peptide (PAR-
4 AP), a synthetic peptide, serves as a surrogate for thrombin and
activates the platelet through the PAR-4 receptor in the P2Y12
assays.
PAR-4 PAR-4 activating peptide (PAR-4 AP), a synthetic peptide, serves
activating as a surrogate for thrombin and activates the platelet through the
peptide PAR-4 receptor in the P2Y12 assay. It is used to determine the
Base result.
Password When operator identification is enabled, a user identification
number and a matching password number are required to use the
instrument.
Patient A feature that assigns a patient identification (ID) to each patient
Identification sample.
PAU See platelet aggregation units.
Pellet A hygroscopic substance provided in the Assay WQC kit and used
in Level 2 wet quality control testing. The active ingredient is a
peptide that gives results that mimic platelet function in an
uninhibited sample.
VerifyNow System User Manual Page 113
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