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1
ACQUITY UPC
The ACQUITY
liquid carbon dioxide (CO
achiral separations.
You control the system using the driver pack software that you access through one of these
Waters' data systems: Empower
1.1
Using ACQUITY UPC
chromatography
ACQUITY UPC
advantages over traditional HPLC normal-phase chromatography:
•
Uses liquid CO
phase.
•
Combines liquid CO
and isopropanol, to increase the solvent strength for separating polar compounds.
•
Minimizes health, safety, and environmental concerns associated with chemical solvents.
•
Runs at higher flow rates (3 to 5 times higher than HPLC for the columns of the same
dimension) because of its high diffusivity.
•
Produces lower pressure drops across the column and faster separations, because of the
mobile phases's low viscosity.
Figure 1–1:
75 bar
®
2®
UPC
(Ultra Performance Convergence Chromatography) system uses
) as the primary mobile phase for normal-phase, chiral, and
2
®
2
2
chromatography is a normal-phase chromatographic technique that offers these
, a chemically pure, stable, and nonpolar solvent, as the primary mobile
2
with one or more organic solvents, typically alcohols such as methanol
2
Pressure-temperature phase diagram for CO
Temperature
November 16, 2016, 715004521 Rev. C
2
system
software or MassLynx
®
for normal-phase
Page 13
software.
2
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