Agilent Technologies 1260 Infinity II User Manual page 49

3
Using the Pump
Solvent Information
Material Information
Materials in the flow path are carefully selected based on Agilent's experiences
in developing highest quality instruments for HPLC analysis over several
decades. These materials exhibit excellent robustness under typical HPLC
conditions. For any special condition, please consult the material information
section or contact Agilent.
Disclaimer
Subsequent data was collected from external resources and is meant as a
reference. Agilent cannot guarantee the correctness and completeness of such
information. Data is based on compatibility libraries, which are not specific for
estimating the long-term life time under specific but highly variable conditions of
UHPLC systems, solvents, solvent mixtures and samples. Information can also
not be generalized due to catalytic effects of impurities like metal ions,
complexing agents, oxygen etc. Apart from pure chemical corrosion, other effects
like electro corrosion, electrostatic charging (especially for non-conductive
organic solvents), swelling of polymer parts etc. need to be considered. Most data
available refers to room temperature (typically 20 – 25 °C, 68 – 77 °F). If
corrosion is possible, it usually accelerates at higher temperatures. If in doubt,
please consult technical literature on chemical compatibility of materials.
PEEK
PEEK (Polyether-Ether Ketones) combines excellent properties regarding
biocompatibility, chemical resistance, mechanical and thermal stability. PEEK is
therefore the material of choice for UHPLC and biochemical instrumentation.
It is stable in the specified pH range (for the Bio-inert LC system: pH 1 – 13, see
bio-inert module manuals for details), and inert to many common solvents.
There is still a number of known incompatibilities with chemicals such as
chloroform, methylene chloride, THF, DMSO, strong acids (nitric acid > 10 %,
sulphuric acid > 10 %, sulfonic acids, trichloroacetic acid), halogenes or aequous
halogene solutions, phenol and derivatives (cresols, salicylic acid etc.).
When used above room temperature, PEEK is sensitive to bases and various
organic solvents, which can cause it to swell. Under such conditions normal
PEEK capillaries are very sensitive to high pressure. Therefore Agilent uses
stainless-steel cladded PEEK capillaries in bio-inert systems. The use of stainless
steel cladded PEEK capillaries keeps the flow path free of steel and ensures
pressure stability to at least 600 bar. If in doubt, consult the available literature
about the chemical compatibility of PEEK.
InfinityLab LC Series 1260 Infinity II Binary Pump User Manual 49