Electron Transfer Dissociation; Types Of Experiments - Thermo Scientific ETD Getting Started Manual

1
Introduction

Electron Transfer Dissociation

Electron Transfer Dissociation

Types of Experiments

2 MS/ETD System Getting Started Guide
ETD provides peptide dissociation by transferring electrons to positively charged peptides,
leading to a rich ladder of sequence ions derived from cleavage at the amide groups along the
peptide backbone. Amino acid side chains and important modifications such as
phosphorylation are left intact.
The New Method page of the Instrument Setup window for the LTQ XL
LTQ Velos MS detector has buttons for the various types of experiment templates. Open the
template for a particular experiment type, enter the parameters for the experiment, and then
save the entries as part of an Xcalibur instrument method.
The New Method page has two experiment categories:
• LTQ XL and LTQ Velos Experiment Types
• ETD Experiment Types
(Figure 1) or
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