Solving Your Problem - Agilent Technologies 8453 User Manual, Installing And Operating Manual

8 Repeat the check with the tubing for valve positions 1, 3, 5, and 7 in the
9 Compare the results with the solvent reference.
If there is more than 0.5% contamination of solvent by the sample solution:
1 Check for flow restrictions, see
2 Clean the tubing and valve, see
3 If the problem remains, replace the valve, see

Solving Your Problem

This subsection gives instructions for:
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Cleaning Tubing and Valve
Your choice of solvent depends on your application. Ensure good miscibility of solvents and
N O T E
check for solubility of residues from your sample and salts from previous solutions. Make
sure the solvent is compatible with the PEEK, PPS and PTFE materials of the valve and
tubing. You may also choose to use a detergent for cleaning.
1 Place the inlet tubings in clean solvent and connect the outlet to your pump.
2 Pump solvent though the tubing and the valve for a few minutes.
3 Move the valve to the next position.
4 Pump solvent again and change the valve position until all ports have been
Agilent 8453 Dissolution Testing System Installing and Operating Manual
sample solution and for valve positions 2, 4, 6, and 8 in the solvent.
Flow:" on page 90.
"Cleaning Tubing and Valve"
"Changing Valve" on page 92
"Replacing Fittings"
Place the outlet from the pump in a waste container.
cleaned.
Using the Valve Unit and Valve-pump Controller
Troubleshooting Your Valve System
"To check for Flow Restrictions—Too Low
"Cleaning Tubing and Valve"
on page 91
on page 94
on page 91.
"Changing Valve" on page 92.
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91