Hgb Concentration Variance (Hcvar); Hyperchromia (Hyper) - Siemens ADVIA 2120 Operator's Manual

HGB Concentration Variance (HCVAR)

Definition
The Hgb Concentration Variance flag is triggered if the variation in cell
hemoglobin concentration (HDW) is equal to or greater than 3.4 g/dL.
The Hemoglobin Distribution Width (HDW) parameter is the standard deviation
of the cellular hemoglobin concentration distribution on the RBC HC histogram.
Default trigger values for the three severity levels are:
+
++
+++
Results Flagged
none
Possible Causes
The following list of sample-related causes may not contain all conditions that
could cause this flag.
Multiple occurrences of this flag, especially for consecutive samples, can indicate
a system problem. However, isolated instances of this flag are usually sample
related.
Sample Related
•
Sickle cell anemia·
•
Iron deficiency anemia·
•
Hemolytic anemia
•
Transfusion

Hyperchromia (HYPER)

Definition
The Hyperchromia flag is triggered if the percentage of cells with high (> 41g/dL)
cellular hemoglobin concentration (%HYPER) is equal to or greater than 4.0%.
The %HYPER parameter indicates the percent of cells that have a cellular
hemoglobin concentration greater than 41 g/dL and is derived from the RBC HC
histogram.
Default trigger values for the three severity levels are:
+
++
+++
6-8
HDW% = 3.4 g/dL to 3.9 g/dL
HDW% = 4.0 g/dL to 4.6 g/dL
HDW% > 4.6 g/dL
%HYPER = 4.0% to 7.9%
%HYPER = 8.0% to 12.0%
%HYPER > 12.0%
System Related
1. Check RBC reagents.
2. Check RBC hydraulics.
3. Check RBC gains.
4. Check laser flowcell alignment.
Flags