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3
CI Troubleshooting
If MS was recently switched from EI to CI
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No PFDTD peaks in PCI
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No reagent gas peaks in NCI
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No PFDTD calibrant peaks in NCI
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No sample peaks in NCI
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7250 Accurate-Mass Q-TOF Troubleshooting and Maintenance Manual
No reagent gas flow
Analyzer not sealed (big air leak)
Wrong tune file loaded or tune file corrupted
Ion source not assembled or connected correctly
Wrong reagent gas selected for the tune file (looking for wrong ions)
Incorrect reagent gas. There are no PCI PFDTD peaks created with isobutane
or ammonia. Switch to methane.
Analyzer not sealed (big air leak)
No calibrant in vial
Defective calibration valve(s)
Air leak in carrier or reagent gas path
Reagent gases do not ionize in NCI; look for background ions instead
Verify tune parameters
If no background ions are visible, go back to methane PCI
Look for background ions: 35 (Cl
Verify tune parameters
Go back to methane PCI
Look for background ions: 35 (Cl
Go back to methane PCI
Poor quality reagent gas (purity less than 99.99%)
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), and 235 (ReO3
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), and 235 (ReO3
)
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Table of Contents
Troubleshooting
