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CI Troubleshooting
Troubleshooting Tips and Tricks
Rule 1: "Look for what has been changed."
Many problems are introduced accidentally by human actions. Every time any
system is disturbed, there is a chance of introducing a new problem.
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Rule 2: "If complex isn't working, go back to
simple."
A complex task is not only more difficult to perform, but also more difficult to
troubleshoot as well. For example, CI requires more parts to work correctly than
EI does.
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Rule 3: "Divide and conquer."
This technique is known as "half-split" troubleshooting. If you can isolate the
problem to only part of the system, it is much easier to locate.
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7250 Accurate-Mass Q-TOF Troubleshooting and Maintenance Manual
If the MS was just pumped down after maintenance, suspect air leaks or
incorrect assembly.
If the reagent gas bottle or gas purifier were just changed, suspect leaks or
contaminated or incorrect gas.
If the GC column was just replaced, suspect air leaks or contaminated or
bleeding column.
If you have just switched ion polarity or reagent gas, suspect the tune file you
have loaded in memory. Is it the appropriate file for your mode of operation?
If you are having trouble with NCI, verify that PCI still works.
If you are having trouble with other reagent gases, verify that methane still
works.
If you are having trouble with CI, verify that EI still works.
To isolate an air leak, select Shutoff valve. If abundance of m/z 32 decreases,
the problem is not in the flow module.
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Table of Contents
Troubleshooting
