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General Troubleshooting
Peaks have split tops
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Baseline is rising
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Baseline is high
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Baseline is falling
A falling baseline indicates contamination is being swept away. Wait until the
baseline reaches an acceptable level. Common causes include:
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7250 Accurate-Mass Q-TOF Troubleshooting and Maintenance Manual
Bad injection technique
Injection is too large
Column bleed
Other contamination
Column bleed
Other contamination
Residual air and water from a recent venting
Column bleed
Septum bleed
Splitless injection time too long (inlet is not properly swept, resulting in
excess solvent on the column and slow solvent decay)
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