Abnormal Baseline Troubleshooting - Waters 2410 Operator's Manual

Table 7-1 Abnormal Baseline Troubleshooting
Symptom
Baseline drift, rapid
7
Baseline drift, slow
Baseline drift, descending
91 Troubleshooting
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Possible Cause Corrective Action
Column not equilibrated Equilibrate column.
Detector not allowed to Allow detector to warm up
warm up until baseline is stable.
Warm-up time varies
based on sensitivity.
Solvent contaminated or Use fresh solvent.
not HPLC grade
Solvent not properly Degas the solvent. Cap the
degassed (rapid or slow solvent reservoir.
drift)
Tubing contaminated Clean the tubing using the
procedure in
Cleaning the Fluidic
Flow fluctuations (rapid Fix pump problems,
or slow drift) replace pump seals, check
valves.
Solvent contaminated Use fresh, degassed
solvent.
Ambient temperature Stabilize operating
fluctuations environment temperature
enough to allow full
equilibration. Keep the
system away from air
conditioning vents, chance
breezes, and direct
sunlight.
Dirty flow cell Clean flow cell
(Section 6.1, Cleaning the
Fluidic
Leaky flow cell Call Waters Technical
Service.
Section 6.1,
Path.
Path).