Refractive Indices Of Common Solvents - Waters 2410 Operator's Manual

Tetrahydrofuran (THF)
When you use unstabilized THF, ensure that your solvent is fresh. Previously opened
bottles of THF contain peroxide contaminants, which cause baseline drift.
Caution: THF contaminants (peroxides) are potentially explosive if concentrated or taken
to dryness.

Refractive Indices of Common Solvents

Table 4-1 lists the refractive indices for some common chromatographic solvents. Use this
table to verify that the solvent you intend to use for your analysis has an RI significantly
different from the sample components.
Table 4-1 Refractive Indices of Common Solvents
Solvent
Fluoroalkanes
Hexafluoroisopropanol
(HFIP)
Methanol
Water
Acetonitrile
Ethyl ether
n-Pentane
Acetone
Ethanol
Methyl acetate
Isopropyl ether
Ethyl acetate
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RI Solvent
1.25 Tetrahydrofuran (THF)
1.2752 Amyl alcohol
1.329 Diisobutylene
1.33 n-Decane
1.344 Amyl chloride
1.353 Dioxane
1.358 Ethyl bromide
1.359 Methylene chloride
1.361 Cyclohexane
1.362 Ethylene glycol
1.368 N,N-dimethyl formamide
(DMF)
1.370 N,N-dimethyl acetamide
(DMAC)
RI
1.408
1.410
1.411
1.412
1.413
1.422
4
1.424
1.424
1.427
1.427
1.428
1.438
Selecting a Solvent 62