Waters 2410 Operator's Manual page 67

Vacuum Degassing
The longer a solvent is exposed to the vacuum, the more dissolved gases are removed.
Two factors affect the amount of time the solvent is exposed to the vacuum:
• Flow rate – At low flow rates, most of the dissolved gas is removed as the solvent
passes through the vacuum chamber. At higher flow rates, lesser amounts of gas
per unit volume of solvent are removed.
• Surface area of the degassing membrane – The length of the degassing
membrane is fixed in each vacuum chamber. To increase the length of membrane,
you can connect two or more vacuum chambers in series.
The in-line degasser is available as an option or factory-installed in the Waters
Separations Module, XE model.
When you are using the 2690 Separations Module with the 2410 refractometer, set the
in-line degasser to "continuous" degas mode.
Select the most efficient degassing operation for your application. To remove dissolved
gas quickly, consider the following degassing considerations.
Sonication Plus Vacuum
Sonication combined with vacuum degasses solvent very quickly. This technique is less
likely to change the composition of mixed solvents because the mixed solvents are held
under vacuum for only a short time (less than a minute is usually sufficient).
Caution: Do not apply vacuum to the brown glass bottles in which solvent is shipped.
There is a high risk of implosion under these conditions. Use a thick-walled container
designed for vacuum applications.
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Solvent Degassing 66