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8
Maintenance
Cleaning the Nebulizer
Cleaning the Nebulizer
A loss of sensitivity is a common indicator that the nebulizer requires cleaning.
Flushing can remove blockages. Therefore it is recommended to initially flush the
instrument with a suitable solvent (for example water).
The most common cause of nebulizer blockage is precipitation of mobile phase
buffer. This blockage occurs either at the nebulizer tip or within the inlet tube
leading to the nebulizer.
To clean the nebulizer, the following procedure is recommended.
1 Put the ELSD into RUN mode.
2 Set the evaporator and nebulizer temperature to 40 °C and the gas flow to
3 Set pump flow rate to 5 mL/min.
4 Remove the column, select a suitable solvent (for example water if using
Pump the highest flow-rate possible if backpressure of ELSD is too high at
NOTE
5 mL/min.
If the nebulizer becomes completely blocked, it is not possible to pump solvent
NOTE
into the ELSD.
It is recommended to regularly flush the ELSD with water to keep the nebulizer
clear of obstruction.
Agilent InfinityLab ELSD User Manual
1.6 SLM.
aqueous buffers) and pump for 3 h or set pump flow rate to 1 mL/min and run
overnight.
90
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