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Manual
00809-0500-4881
Toxicology
A number of studies on the health effects of inhalation exposure of rats and hamsters are
available. Rats were exposed to RCF in a series of life-time nose-only inhalation studies. The
animals were exposed to 30, 16, 9, and 3 mg/m
200, 150, 75, and 25 fibers/cc.
Animals exposed to 30 and 16 mg/m
parenchymal fibrosis; animals exposed to 9 mg/m
fibrosis; animals exposed to the lowest dose were found to have the response typically
observed any time a material is inhaled into the deep lung. While a statistically significant
increase in lung tumors was observed following exposure to the highest dose, there were
no excess lung cancers at the other doses. Two rats exposed to 30 mg/m
exposed to 9 mg/m
The International Agency for Research on Cancer (IARC) reviewed the carcinogenicity data
on man-made vitreous fibers (including ceramic fiber, glasswool, rockwool, and slagwool)
in 1987. IARC classified ceramic fibers, fibrous glasswool, and mineral wool (rockwool and
slagwool) as possible human carcinogens (Group 2B).
A.2.3
First aid
•
Eye contact: Flush eyes immediately with large amounts of water for approximately 15
minutes. Hold eye lids away from eyeballs to ensure thorough rinsing. Do not rub eyes.
Get medical attention if irritation persists.
•
Inhalation: Remove person from source of exposure and move to fresh air. Some
people may be sensitive to fiber induced irritation of the respiratory tract. If symptoms
such as shortness of breath, coughing, wheezing, or chest pain develop, seek medical
attention. If person experiences continued breathing difficulties, administer oxygen
until medical assistance can be rendered.
•
Ingestion: Do not induce vomiting. Get medical attention if irritation persists.
•
Skin contact: Do not rub or scratch exposed skin. Wash area of contact thoroughly with
soap and water. Using a skin cream or lotion after washing may be helpful. Get medical
attention if irritation persists.
A.2.4
Fire and explosion data
Flash point
Flammability limits
Extinguishing media
Unusual fire and explosion hazards / special
fire fighting procedures
A.2.5
Accidental release
Steps to be taken if material is released or spilled
Where possible, use vacuum suction with HEPA filters to clean up spilled material. Use dust
suppressant where sweeping if necessary. Avoid clean up procedure which may result in
water pollution. (See
Rosemount OCX8800C
that plaques are not pre-cancer, nor are they associated with any measurable effect
in lung function.
3
developed masotheliomas.
Exposure and personal protection equipment
3
, which corresponds with approximately
3
were observed to have developed a pleural and
3
had developed a mild parenchymal
None
N/A
Use extinguishing agent suitable for type of
surrounding fire.
N/A
Safety data
April 2023
3
and one rat
(PPE)).
281
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