Optimization Of Legacy Compressibility Settings - Agilent Technologies 1260 Infinity II User Manual

Optimization of Legacy Compressibility Settings

The compressibility compensation default settings are 50 × 10
most aqueous solutions) for pump head A and 115 × 10
solvents) for pump head B. The settings represent average values for aqueous
solvents (A side) and organic solvents (B side). Therefore it is always
recommended to use the aqueous solvent on the A side of the pump and the
organic solvent on the B side. Under normal conditions, the default settings
reduce the pressure pulsation to below 2 % of system pressure, which is
sufficient for most applications. If the compressibility values for the solvents
used differ from the default settings, it is recommended to change the
compressibility values accordingly. Compressibility settings can be optimized
by using the values for various solvents described in
solvent in use is not listed in the compressibility table, when using premixed
solvents and if the default settings are not sufficient for your application, the
following procedure can be used to optimize the compressibility settings:
1 Start channel A of the binary pump with the required flow rate.
2 Before starting the optimization procedure, the flow must be stable. Use
3 Your pump must be connected to an Agilent data system or Instant Pilot,
4 Start the recording device in plot mode.
5 Starting with a compressibility setting of 40 × 10
6 Repeat step 1 through step 5 for the B channel of your binary pump.
InfinityLab LC Series 1260 Infinity II Binary Pump User Manual
How to Optimize the Compressibility Compensation Setting
degassed solvent only. Check the tightness of the system with the pressure
test (see "(System) Pressure Test"
the pressure- and %-ripple can be monitored with one of these instruments.
in steps of 10. The compressibility compensation setting that generates the
smallest pressure ripple is the optimum value for your solvent composition.
Optimizing Performance
-6
Table 8
on page 96).
-6
/bar, increase the value
4
-6
/bar (best for
/bar (to suit organic
on page 68. If the
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