Agilent Technologies 1290 Infinity User Manual page 53

Solvent compatibility for stainless steel in standard LC systems
Stainless steel is inert against many common solvents. It is stable in the
presence of acids and bases in the pH range specified for standard HPLC (pH 1
– 12.5 ). It can be corroded by acids below pH 2.3 . In general following
solvents may cause corrosion and should be avoided with stainless steel:
• Solutions of alkali halides, their respective acids (for example, lithium
• High concentrations of inorganic acids like nitric acid, sulfuric acid and
• Halogenated solvents or mixtures which form radicals and/or acids, for
• Chromatographic grade ethers, which can contain peroxides (for example,
• Solutions of organic acids (acetic acid, formic acid, and so on) in organic
• Solutions containing strong complexing agents (for example, EDTA,
• Mixtures of carbon tetrachloride with 2-propanol or THF.
Agilent 1290 Infinity Valve Drive and Valve Heads
iodide, potassium chloride, and so on) and aequous solutions of halogenes
organic solvents especially at higher temperatures (replace, if your
chromatography method allows, by phosphoric acid or phosphate buffer
which are less corrosive against stainless steel).
example:
→ 2 COCl
2 CHCl + O
3 2
This reaction, in which stainless steel probably acts as a catalyst, occurs
quickly with dried chloroform if the drying process removes the stabilizing
alcohol.
THF, dioxane, di-isopropylether) such ethers should be filtered through dry
aluminium oxide which adsorbs the peroxides.
solvents. For example, a 1 % solution of acetic acid in methanol will attack
steel.
ethylene diamine tetra-acetic acid).
+ 2 HCl
2
Using the Module
Solvent Information
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