Adjusting The Transfer Line Temperature - Thermo Scientific ISQ User Manual

Adjusting the Transfer Line Temperature

Thermo Scientific
If your transfer line temperature is set too low, the less volatile compounds may get stuck in
the transfer line and never make it into the ion source. On the other hand, if your transfer line
is too hot, you could damage the column or cause a thermal breakdown in the compounds
you are analyzing. Typically, the transfer line temperature should be 10 °C over the highest
boiling point of the compounds of interest, but no more than the maximum safe operating
temperature of the column. Increase the source temperature as well to improve response for
high-boiling compounds and prevent column bleed and matrix compounds from dirtying the
ion source.
Note The transfer line temperature and ion source temperature should be similar to avoid
contaminating the ion source.
7
Optimizing Your Method
Adjusting the Transfer Line Temperature
ISQ User Guide 87