I-Stat Celite Act And I-Stat Kaolin Act; Heparin Linearity Procedure - Abbott i-STAT 1 System Manual

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INTRODUCTION

The i-STAT Celite ACT and the i-STAT Kaolin ACT tests are intended for in vitro diagnostic use. This test

can be performed at the bedside using venous or arterial whole blood. The i-STAT Celite ACT is commonly

used for heparin anticoagulation monitoring for adults during cardiopulmonary bypass (CPB) surgery

and percutaneous transluminal coronary angioplasty (PTCA). The i-STAT Kaolin ACT is used for heparin

anticoagulation monitoring during cardiopulminary bypass (CPB) surgery, and can be used in the presence

of aprotinin. The i-STAT ACT tests can be performed using the i-STAT Portable Clinical Analyzer or i-STAT

1 Analyzer. The reportable range of the i-STAT ACT test is from 50-1000 seconds.

The i-STAT ACT tests have demonstrated linearity between 0.0 and 6.0 units of heparin in blood samples

from normal, healthy volunteers.

An in vitro heparin sensitivity curve was generated by adding increasing amounts of heparin to aliquots

of normal donor blood (See graph below which serves as an example only. Each patient demonstrates a

unique dose-response curve.)

Abbott Point of Care Inc. • Abbott Park, IL 60064 • USA

Technical BulleTin

ACT and i-STAT

Linearity Procedure

Art: 714547-00F

Kaolin ACT Heparin

Rev. Date: 06/11/08

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