How To Use Miscibility Numbers - Waters 2998 Overview And Maintenance Manual

Table C–1: Solvent miscibility (continued)
Polarity
Solvent
Index
3.9 Butyl alcohol
3.9 Butanol
4.2 Tetrahydrofuran
4.3 Ethyl acetate
4.3 1-propanol
4.3 2-propanol
4.4 Methyl acetate
4.5 Methyl ethyl ketone
4.5 Cyclohexanone
4.5 Nitrobenzene
4.6 Benzonitrile
4.8 Dioxane
5.2 Ethanol
5.3 Pyridine
5.3 Nitroethane
5.4 Acetone
5.5 Benzyl alcohol
5.7 Methoxyethanol
6.2 Acetonitrile
6.2 Acetic acid
6.4 Dimethylformamide
6.5 Dimethylsulfoxide
6.6 Methanol
7.3 Formamide
9.0 Water
C.2.1

How to use miscibility numbers

Use miscibility numbers (M-numbers) to predict the miscibility of a liquid with a standard solvent
(see page 84).
To predict the miscibility of two liquids, subtract the smaller M-number value from the larger
M-number value.
• If the difference between the two M-numbers is 15 or less, the two liquids are miscible in all
proportions at 15 C.
A difference of 16 indicates a critical solution temperature from 25 C to 75 °C, with 50 °C
•
as the optimal temperature.
• If the difference is 17 or greater, the liquids are immiscible or their critical solution
temperature is above 75 °C.
Viscosity
CP, 20 C
3.00
3.01
0.55
0.47
2.30
2.35
0.45
0.43
2.24
2.03
1.22
1.54
1.20
0.94
0.68
0.32
5.80
1.72
0.37
1.26
0.90
2.24
0.60
3.76
1.00
December 5, 2017, 715004753 Rev. B
Page 85
Boiling
Miscibility
Point C
Number (M)
(1 atm)
117.7 ––-
177.7 15
66.0 17
77.1 19
97.2 15
117.7 15
56.3 15, 17
80.0 17
155.7 28
210.8 14, 20
191.1 15, 19
101.3 17
78.3 14
115.3 16
114.0 ––
56.3 15, 17
205.5 13
124.6 13
81.6 11, 17
117.9 14
153.0 12
189.0 9
64.7 12
210.5 3
100.0 ––
 Cutoff
(nm)
––
––
220
260
210
––-
260
330
210
––
––
220
210
305
––
330
––
––
190
––
––
––
210
––
––