Solvent Recommendation For Agilent 1290 Infinity And 1290 Infinity Ii And 1260 Infinity Ii Flexible Pumps - Agilent Technologies 1290 Infinity User Manual

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Using the Module

Solvent Recommendation for Agilent 1290 Infinity and 1290 Infinity II and 1260 Infinity II Flexible Pumps

Solvent Recommendation for Agilent 1290 Infinity and 1290
Infinity II and 1260 Infinity II Flexible Pumps
While the Agilent 1290 Infinity, 1290 Infinity II, and 1260 Infinity II Flexible
Pumps guarantee a high performance with a wide variety of solvents, other
solvents may cause harm to the pump or to the (U)HPLC system. No
modifications are necessary when using standard reversed phase applications
with water and other polar protic solvents in combination with most polar
aprotic solvents. Normal phase applications work well with the modifications
detailed in the section
Corrosion can occur in stainless steel systems if free halides, hydroperoxides,
free radicals or strong, oxidizing acids are present. There are several solvents
where, under nonideal conditions, reactions can occur and these harmful
compounds are generated. Prevent formation of reactive substances when
using the following solvents:
• Solutions of alkali halides and their respective acids (for example, lithium
• High concentrations of inorganic acids like sulfuric acid and nitric acid,
• Halogenated organic solvents or mixtures which form radicals and/or acids
• Chromatographic grade ethers, which can contain peroxides (for example,
• Solvents containing strong complexing agents (for example, EDTA).
All these solvents can be used in Agilent (U)HPLC systems. Refer to the
Technical Note Best Practices for Addressing Problems Associated With
Unstable Solvents in an (U)HPLC Environment (01200-90092), for
recommendations on how to avoid damage to the instrument or separation
column when working with these solvents.
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iodide, potassium chloride, and so on)
especially at higher temperatures
(for example, chloroform, methylene chloride)
THF, dioxane, di-isopropylether)
"Normal Phase Applications"
1290 Infinity Quaternary Pump User Manual
on page 85.