Christ Beta 1-8 LSCbasic Operating Manual
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Christ Beta 1-8 LSCbasic Operating Manual

Freeze-dryer
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Translation of the original operating manual
sb-dc
Freeze-dryer
Rev. 1.5 of 09/03/2020
Beta 1-8 LSCbasic;Freeze-dryer;Beta 2-8 LSCbasic; ;
Version 03/2018
Beta 1-8 LSCbasic
Part no. 102420, 102422, 102424, 102426, 102428, 102430
Beta 2-8 LSCbasic
Part no. 102421, 102423, 102425, 102427, 102429, 102431
Operating Manual
Freeze-dryer
Please retain for later use!

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  • Page 1 Translation of the original operating manual sb-dc Freeze-dryer Rev. 1.5 of 09/03/2020 Beta 1-8 LSCbasic;Freeze-dryer;Beta 2-8 LSCbasic; ; Version 03/2018 Beta 1-8 LSCbasic Part no. 102420, 102422, 102424, 102426, 102428, 102430 Beta 2-8 LSCbasic Part no. 102421, 102423, 102425, 102427, 102429, 102431...
  • Page 2 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic Version 03/2018, Rev. 1.5 of 09/03/2020 • sb-dc 2 / 107 Translation of the original operating manual...
  • Page 3 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic In case of inquiries, please state the following numbers: Order number: Serial number: © Copyright by Martin Christ Gefriertrocknungsanlagen GmbH An der Unteren Söse 50 37520 Osterode am Harz Germany Tel.: +49 (0) 5522 / 5007-0...
  • Page 4 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic Version 03/2018, Rev. 1.5 of 09/03/2020 • sb-dc 4 / 107 Translation of the original operating manual...

  • Page 5: Table Of Contents

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic Table of contents General information ......................9 Importance of the operating manual .................. 9 Intended use ........................9 Warranty and liability....................... 11 Copyright ........................12 Explanation of symbols ....................12 Standards and regulations ....................12 Scope of supply ......................
  • Page 6 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic Table of contents Safety devices ........................ 29 3.8.1 System check ......................29 3.8.2 Earth conductor check ....................29 Procedures in the event of hazards and accidents ............30 3.10 Maintenance and cleaning of the freeze-dryer ..............30 3.11...
  • Page 7 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic Table of contents Malfunctions and error correction ..................68 General malfunctions ...................... 68 7.1.1 Power failure ......................69 7.1.2 Insufficient vacuum ....................70 7.1.2.1 Small flange connections ................... 70 7.1.2.2 Aeration valve, media drain valve ..............71 7.1.2.3...
  • Page 8 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic Table of contents Version 03/2018, Rev. 1.5 of 09/03/2020 • sb-dc 8 / 107 Translation of the original operating manual...

  • Page 9: General Information

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 1 General information → General information → Importance of the operating manual A fundamental requirement for the safe and trouble-free operation of the unit is to be familiar with the fundamental safety instructions and all possible hazards.
  • Page 10 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 1 General information The following table can be used as a general guide for the expected degradation during normal freeze-drying processes of organic solvents with a total max. concentration of 10 vol-% in aqueous solutions.

  • Page 11: Warranty And Liability

    Any other use beyond this area of application is regarded as improper use. Martin Christ Gefriertrocknungsanlagen GmbH cannot be held liable for any damage resulting from such improper use.

  • Page 12: Copyright

    Freeze-dryer Beta 2-8 LSCbasic 1 General information → Copyright The copyright concerning the operating manual remains with Martin Christ Gefriertrocknungsanlagen GmbH. The operating manual is solely intended for the operator and their personnel. It includes instructions and information that may not be •...

  • Page 13: Layout And Mode Of Operation

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 2 Layout and mode of operation → Layout and mode of operation → Layout of the freeze-dryer → 2.1.1 Functional and operating elements Ice condenser chamber LSCplus user interface (see chapter 6.5.1 - "User interface")
  • Page 14 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 2 Layout and mode of operation Aeration valve Media drain valve Fig. 3: Left side of the freeze-dryer Touchpanel Fig. 4: User interface with touchpanel Version 03/2018, Rev. 1.5 of 09/03/2020 • sb-dc...

  • Page 15: Name Plate

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 2 Layout and mode of operation 10 Heat exchanger of the refrigeration unit 11 Name plate (see chapter 2.1.2 - "Name plate") 12 Vacuum connection 13 Serial interface 14 Electrical connection of the...

  • Page 16: Mode Of Operation

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 2 Layout and mode of operation → Mode of operation → 2.2.1 General information on freeze-drying What is freeze-drying? Freeze-drying or lyophilisation is a procedure for the gentle drying of high- quality products. The product is dried by → sublimation without passing through the liquid phase.
  • Page 17 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 2 Layout and mode of operation Fig. 7: Vapour pressure curve for ice and water From a physical point of view, the freeze-drying process covers three phases (see figure below): (1) Freezing: The product to be dried is frozen under atmospheric pressure.

  • Page 18: Freeze-Drying Process

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 2 Layout and mode of operation Fig. 8: Freeze-drying phases Please find further information about basic principles, optimum procedures and applications in the brochure "Smart freeze-drying", which can be downloaded at www.martinchrist.de → [Applications] →...

  • Page 19: Freezing

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 2 Layout and mode of operation 2.2.2.2 Freezing First, the product that is to be dried is frozen. Especially in the case of small filling quantities, we recommend pre-cooling the shelves as well in order to prevent the product from thawing during the evacuation.

  • Page 20: Final Drying

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 2 Layout and mode of operation → 2.2.2.4 Final drying Final drying is an option whenever one requires a product with minimal residual moisture. In the physical sense, this process is a desorption process, i.e.

  • Page 21: Safety

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 3 Safety → Safety → Marking of the unit The following symbols are used for Christ freeze-dryers: Dangerous voltage On (Power) Hot surface Off (Power) Name plate (see chapter Caution! Risk of bruising 2.1.2 - "Name plate")

  • Page 22: Explanation Of The Symbols And Notes

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 3 Safety → Explanation of the symbols and notes This operating manual uses the following names and symbols to indicate hazards: This symbol stands for a direct hazard to the life and health of persons.

  • Page 23: Responsibility Of The Operator

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 3 Safety → Responsibility of the operator Operating personnel The operator is obliged to ensure that the persons working on/with the freeze-dryer • are 18 years old or older, • have been specifically ordered to do so by the operator/owner and that...

  • Page 24: Operating Personnel

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 3 Safety • concerning the chamber pressure and shelf temperature for every product that is to be processed in the freeze-dryer, • concerning the inspection of the freeze-dryer in view of damage caused by the solvent that is used (see chapter 1.2 - "Intended use", section...

  • Page 25: Safety Notes Concerning The Transport, Set-Up And Connection And Initial Start-Up Of The Freeze-Dryer

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 3 Safety Safety notes concerning the transport, set-up and connection and initial start-up of the freeze-dryer The following notes and instructions must be observed in order to protect all persons and property.

  • Page 26: Hazards Caused By Improper Connection

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 3 Safety 3.6.4 Hazards caused by improper connection Risk of injury caused by consequences of improper connection Improper connection may lead to a hazardous electrical incident at a later time during the operation of the freeze-dryer.

  • Page 27: Hazards Caused By The Refrigeration System (Natural, Flammable Refrigerants)

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 3 Safety 3.7.2 Hazards caused by the refrigeration system (natural, flammable refrigerants) Risk of explosion due to refrigerants The refrigerants used are highly flammable and can form an explosive mixture if their concentration in the ambient air is sufficiently high.

  • Page 28: Hazards Caused By Harmful Products

    This may lead to severe injuries. DANGER Freeze-drying of products containing acids is only permissible if special protective measures and equipment-related precautions are taken! Consultation of Martin Christ Gefriertrocknungsanlagen GmbH is absolutely mandatory in order to define the measures that need to be taken! •...

  • Page 29: Hazards Caused By Contaminated Condensate (Defrosting Water)

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 3 Safety 3.7.7 Hazards caused by contaminated condensate (defrosting water) Risk of poisoning/infection caused by contaminated condensate (defrosting water) The condensate may contain harmful substances originating from the product. WARNING Contact with the condensate may cause severe damage to health.

  • Page 30: Procedures In The Event Of Hazards And Accidents

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 3 Safety → Procedures in the event of hazards and accidents Hazardous electrical incident: • Set the control switch to the "0" position in order to interrupt the power supply completely. Fire: •...

  • Page 31: Measures To Be Taken To Ensure Safe Operation Of The Freeze-Dryer

    • Stop the freeze-dryer immediately in the event of a malfunction. Eliminate the malfunction (see chapter 7 - "Malfunctions and error correction") or contact the after-sales service of Firma Martin Christ Gefriertrocknungsanlagen GmbH (see chapter 7.3 - "Service contact"). •...

  • Page 32: Remaining Hazards

    → 3.12 Remaining hazards All Christ freeze-dryers were built state-of-the-art and according to the accepted safety rules. Danger to life and limb of the operator, or of third parties, or impairments of the units or other material assets, however, cannot be completely excluded when the units are being used.

  • Page 33: Storage And Transport

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 4 Storage and transport → Storage and transport → Dimensions and weight Values for the freeze-dryer without a vacuum pump: Beta 1-8 LSCbasic Beta 2-8 LSCbasic Height: 415 mm 415 mm Width:...

  • Page 34: Notes On Transport

    Do not grab the unit at the plastic control panel (see figures below). correct incorrect Fig. 9: Lifting the freeze-dryer The freeze-dryer Beta 1-8 LSCbasic weighs approx. 63 kg! The freeze-dryer Beta 2-8 LSCbasic weighs approx. 78 kg! CAUTION The centre of gravity of the freeze-dryer is off-centre! CAUTION •...

  • Page 35: Packaging

    Lift the freeze-dryer upwards and out of the crate/cardboard box. When lifting the unit, always reach under the freeze-dryer from the side. The freeze-dryer Beta 1-8 LSCbasic weighs approx. 63 kg! The freeze-dryer Beta 2-8 LSCbasic weighs approx. 78 kg!

  • Page 36: Set-Up And Connection

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 5 Set-up and connection → Set-up and connection → Location of use Use the freeze-dryer solely in closed and dry spaces. Refrigeration problems of the freeze-dryer are often caused by insufficient conditions at the location of use. This is why compliance with the following...

  • Page 37: Power Supply

    The operating voltage on the name plate must correspond to the local supply voltage! DANGER Christ freeze-dryers are units of protection class I. Freeze-dryers of this type have a three-wire power cord with an IEC C13 connector (see chapter 10 - "Technical data").

  • Page 38: Media Drain Valve

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 5 Set-up and connection → Media drain valve Risk of poisoning/infection caused by contaminated condensate (defrosting water) The condensate may contain harmful substances originating from the product. WARNING Contact with the condensate may cause severe damage to health.
  • Page 39 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 5 Set-up and connection • Switch the unit off by actuating the mains power switch. • Take the vacuum sensor out of its original packaging and fasten it to the connector with a bow-shaped connecting piece, two clamping rings (DIN16KF) and two centring rings (included in the scope of supply).

  • Page 40: Vacuum Pump

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 5 Set-up and connection Vak uumpumpe → 5.4.6 Vacuum pump It is absolutely essential to refer to the separate instruction manual of the vacuum pump and exhaust filter (if applicable)! NOTE The vacuum pump must be connected to the vacuum connection of the unit and to the electrical socket at the back of the unit, which is marked accordingly (see chapter 2.1.1 - "Functional and operating elements").

  • Page 41: Pressure Control Valve

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 5 Set-up and connection → Pressure control valve The pressure control valve is integrated in the suction pipe between the vacuum pump and ice condenser chamber. During certain, specified process phases, it interrupts the volume flow to the vacuum pump (see chapter 2.2.1 - "General information on freeze-drying")

  • Page 42: Rubber Valves

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 5 Set-up and connection → Rubber valves The rubber valves (part no. 121860) enable the connection of round-bottom flasks, wide-neck filter bottles, or distributors for ampoules to a manifold or drying chamber. Depending on the connector of the components, the blue plug can be removed.

  • Page 43: Operation

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 6 Operation Operation Initial start-up Before the initial start-up, please ensure that your freeze-dryer is properly set up and installed (see chapter 5 - "Set-up and connection") WARNING → Installation of accessories The accessories must be completed in accordance with the drying method that is applied as well as in accordance with the scope of supply.

  • Page 44: Lscbasic Control System

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 6 Operation LSCbasic control system The control system LSCbasic (Lyo Screen Control basic) was specifically developed for the control of freeze-drying processes. The clear user interface enables the intuitive operation of the unit.

  • Page 45: Main Window "Process

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 6 Operation Process This window is also the standard user interface. It is used to control the freeze-drying process manually. Options This window is used for personalised settings that enable the users to adapt the system as far as possible to their respective area of activity.
  • Page 46 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 6 Operation No USB storage device or LAN network connected symbol USB storage device connected Active process recording on a USB storage device Network available, but no network drive connected Network drive connected (e.g. LyoLogplus) Network drive connected and active process recording Button "Schematic system diagram"...
  • Page 47 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 6 Operation Fig. 21: Dialogue box "Select actual value" • Select the desired configuration or exit the dialogue box by pressing the "return" button. In this way, it is possible to configure a personalised overview of the actual values.
  • Page 48 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 6 Operation Option: USB process recording (see chapter 6.6 - "Optional extensions") • Select the "USB process recording" function in the dialogue box "Tools". • Select the input fields ("Batch data"). A keyboard for the data input will be displayed.
  • Page 49 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 6 Operation There are three categories of faults: • Red: error messages • Orange: process messages • Yellow: general messages The representation of the message provides information about its current status. A double frame around a message means that the error has not been eliminated yet.
  • Page 50 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 6 Operation Use the arrow buttons to open the individual windows. The error message text is always followed by an error code. Always indicate the error code in the event of enquiries or service requests!
  • Page 51 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 6 Operation Button "Standard unit test" Apart from the process phases of the freeze-drying process ("Freezing", "Warm-up", "Main drying" and "Final drying") and the operating mode "Defrosting", the button "Standard unit test" is also available. This button opens a selection of tests with fixed parameters.
  • Page 52 • Select "Leakage test" and start the test via the "Run" button. The parameters for the leakage test have been developed by Martin Christ Gefriertrocknungsanlagen specifically for the freeze-dryers. In a first step, these parameters (vacuum, ice condenser temperature) must be reached.

  • Page 53: Main Window "Options

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 6 Operation 6.5.1.2 Main window "Options" The main window "Options" is where the basic configuration of the control system is defined. It enables the optimum adaptation of the freeze-dryer to its specific area of application.
  • Page 54 • Double-chamber method LyoCube : Drying outside the ice condenser  chamber, but with the CHRIST LyoCube (a rectangular drying chamber that can be loaded from the front) Not available for Alpha 3-4 LSCbasic. Not available for Alpha 3-4 LSCbasic.
  • Page 55 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 6 Operation Fig. 33: Dialogue box "Freeze-drying process" Administration "Administration" options: "Date/Time" "Network" "System properties" "Access protection" "Device options" Fig. 34: Dialogue box "Options" / "Administration" Date/Time (1) The control system is equipped with an integrated, battery-buffered clock.
  • Page 56 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 6 Operation Fig. 35: Dialogue box “Change date/time Network (2) This dialogue box is used to change the network settings. The changes will not become effective until after a restart of the freeze- dryer.
  • Page 57 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 6 Operation System properties (3) This dialogue box is used to change the system settings. Fig. 37: Dialogue box "System properties" Beeper: The beeper sounds in the event of a malfunction, for example.
  • Page 58 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 6 Operation Access protection (4) In this dialogue box, the access rights can be managed on several levels and they can be protected with a password. In the factory setting with activated access protection, data can be viewed but not edited.
  • Page 59 • Select the button "Add option". An input window opens. • Enter the six-digit CHRIST activation code that was supplied for this option. Note that the code is case-sensitive. Options can be removed in the same way. The changes will not become effective until after a restart of the freeze- dryer.
  • Page 60 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 6 Operation Later installation of a vacuum sensor In freeze-dryers that have been delivered without a vacuum sensor, the device option "Sensor: vacuum not installed" is activated at the factory in order to suppress error messages during operation.
  • Page 61 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 6 Operation Fig. 44: Dialogue box "Operating hours" (here: refrigeration unit 1.1) Failure memory (2) The failure memory stores the most recent messages of the process and equipment information system. The messages can be viewed in this dialogue box.
  • Page 62 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 6 Operation • Acknowledge the message. • Change the oil of the vacuum pump. • Reset the operating hour counter in the dialogue box "Vacuum pump oil change" by way of the "reset" button.
  • Page 63 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 6 Operation Sensor adjustment (5) In this dialogue box, the sensors are adjusted based on a predefined reference value. Sensors that are not properly adjusted will lead to incorrect measurements which, in turn, will have a negative effect on the process control.

  • Page 64: Main Window

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 6 Operation 6.5.1.3 Main window "?" This main window includes the most important information concerning your freeze-dryer: Freeze-dryer type Control system type Serial number Manufacturer contact data Details concerning the software version Fig.

  • Page 65: Entering Set Values

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 6 Operation If the value "∞" (infinite) is selected for a process phase, the next phase must be started manually via the button "Operating mode: select/start". NOTE The set values of the active phase can be changed during the process run.
  • Page 66 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 6 Operation Viewing or editing the set values: • Press the button "Set" (see chapter 6.5.1.1 - "Main window "Process""). The following dialogue box will be displayed: "Defrosting" button "Leakage test" button (option) Fig.

  • Page 67: Optional Extensions

    Since absolutely tight components simply do not exist, a leak rate is determined. The parameters for the leakage test have been developed by Martin Christ Gefrier- trocknungsanlagen specifically for freeze-dryers. In a first step, these parameters (vacuum, ice condenser temperature) must be reached.

  • Page 68: Malfunctions And Error Correction

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 7 Malfunctions and error correction → Malfunctions and error correction Malfunctions are displayed in the dialogue box "Process & equipment messages" (see chapter 7.2 - "Process and error messages"). An acoustic signal sounds when an error message is generated.

  • Page 69: Power Failure

    (see chapter 7.3 - "Service contact") If it is impossible to eliminate the errors, contact the Christ service department! NOTE → 7.1.1 Power failure The control system continues with the process after a power failure.

  • Page 70: Insufficient Vacuum

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 7 Malfunctions and error correction → 7.1.2 Insufficient vacuum The vacuum checks must be carried out when the ice condenser is frozen. NOTE → 7.1.2.1 Small flange connections Leakages are often due to improper small flange connections between the various components and hose connections or to leakages in the valves.

  • Page 71: Aeration Valve, Media Drain Valve

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 7 Malfunctions and error correction → 7.1.2.2 Aeration valve, media drain valve Risk of poisoning/infection caused by contaminated condensate (defrosting water) The condensate may contain harmful substances originating from the product. WARNING Contact with the condensate may cause severe damage to health.

  • Page 72: Insufficient Ice Condenser Temperature

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 7 Malfunctions and error correction → 7.1.3 Insufficient ice condenser temperature Ensure sufficient ventilation. Do not place any paper, cloth, or similar material behind or under the unit, since otherwise the air circulation will be impaired.

  • Page 73: Service Contact

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 7 Malfunctions and error correction → Service contact In the event of queries, malfunctions, or spare part enquiries: From Germany: Contact Martin Christ Gefriertrocknungsanlagen GmbH An der Unteren Söse 50 37520 Osterode (Germany) Tel.

  • Page 74: Maintenance And Service

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 8 Maintenance and service → Maintenance and service The freeze-dryer and the accessories are subject to high mechanical and chemical stress. Thorough maintenance performed by the user extends the service life and prevents premature failure.

  • Page 75: Ice Condenser Chamber

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 8 Maintenance and service Cleaning of the freeze-dryer • Switch the freeze-dryer off by actuating the mains power switch and disconnect the power cord from the wall outlet before cleaning. • If the freeze-dryer has been contaminated with toxic, radioactive, or...

  • Page 76: Aeration Valve, Media Drain Valve

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 8 Maintenance and service → 8.1.3 Aeration valve, media drain valve Risk of poisoning/infection caused by contaminated condensate (defrosting water) The condensate may contain harmful substances originating from the product. WARNING Contact with the condensate may cause severe damage to health.

  • Page 77: Heat Exchanger (Only For Air-Cooled Freeze-Dryers)

    • Check the heat exchanger at least once per month for soiling and clean it if necessary. • Please contact the Christ service department if you have any queries (see chapter 7.3 - "Service contact"). 8.1.5 Electrical system Danger of life caused by electric shock There is a risk of electric shock when touching current-carrying components.

  • Page 78: Vacuum Pump

    The other oil changes depend on the operating conditions. In general, an interval of 500 to 1,000 operating hours is sufficient. • Please contact the Christ service department if you have any queries (see chapter 7.3 - "Service contact"). →...

  • Page 79: Refrigeration System

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 8 Maintenance and service 8.1.8 Refrigeration system Risk of explosion due to refrigerants (natural, flammable refrigerants) The natural refrigerants used are highly flammable and can form an explosive mixture if their concentration in the ambient air is sufficiently DANGER high.

  • Page 80: 8.1.10 Accessories

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 8 Maintenance and service Capacitive vacuum sensors Measurement drift due to long-term use, soiling or sudden aeration may occur. • Capacitive vacuum sensors must be adjusted at least once per year. Depending on the actual conditions of use, shorter adjustment intervals may be necessary.

  • Page 81: Service

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 8 Maintenance and service • Please contact us if you have any queries (see chapter 7.3 - "Service contact"). Service In the event of service work that requires the removal of the panels, there is a risk of electric shock or mechanical injury.
  • Page 82 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 8 Maintenance and service Martin Christ Gefriertrocknungsanlagen GmbH An der Unteren Söse 50 37520 Osterode (Germany) 1. Declaration of decontamination As a certified company and due to the legal regulations for the protection of our employees and of the environment, we are obliged to certify the harmlessness of all incoming goods.

  • Page 83: Disposal

    Freeze-dryer Beta 2-8 LSCbasic 9 Disposal → Disposal → Disposal of the freeze-dryer Martin Christ Gefriertrocknungsanlagen GmbH is a registered manufacturer of electric and electronic devices that are solely intended for commercial use. • Comply with all local rules and regulations. →...

  • Page 84: 10 Technical Data

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 10 Technical data → 10 Technical data Manufacturer Martin Christ Gefriertrocknungsanlagen GmbH An der Unteren Söse 50 37520 Osterode (Germany) Type Beta 1-8 LSCbasic Beta 2-8 LSCbasic Part number 102420 102421 Performance data...

  • Page 85: Ambient Conditions

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 10 Technical data Noise level according to DIN 54 dB(A) 54 dB(A) 45635 EMC according to EN 55011 Class B Class B 0.6 kW min 1.1 kW min Heat emission 1.1 kW max 1.6 kW max...

  • Page 86: 11 Appendix

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 11 Appendix → 11 Appendix → 11.1 Brief operating instructions Functional and operating elements: Ice condenser chamberFehler! Textmarke nicht definiert. LSCplus user interface Mains power switch Fig. 57: Total view of the freeze-dryer...
  • Page 87 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 11 Appendix Aeration valve Media drain valve Fig. 59: Left side of the freeze-dryer Touchpanel Fig. 60: User interface with touchpanel Version 03/2018, Rev. 1.5 of 09/03/2020 • sb-dc 87 / 107...
  • Page 88 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 11 Appendix 10 Heat exchanger of the refrigeration unit 11 Name 12 Vacuum connection 13 Serial interface 14 Electrical connection of the vacuum sensor 15 Connection of the vacuum sensor 16 Power supply of...
  • Page 89 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 11 Appendix 4 Switch the unit on 20 to 30 minutes prior to the start of the drying process in order to let the vacuum pump warm up. 5 Place the plate rack on the base plate.
  • Page 90 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 11 Appendix Step-by-step instructions – drying in a flask 1 Freeze the sample separately, e.g. in a deep-freeze. Ensure that the layer thickness of 1 to 2 cm is not exceeded, since otherwise the drying time needs to be extended.
  • Page 91 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 11 Appendix Ensure that no water gets into the pipe connection of the vacuum pump or vacuum sensor. CAUTION 12 Drain the defrosting water via the defrosting water valve on the left-hand side of the unit.
  • Page 92 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 11 Appendix Version 03/2018, Rev. 1.5 of 09/03/2020 • sb-dc 92 / 107 Translation of the original operating manual...

  • Page 93: Ec Declaration Of Conformity In Accordance With The Ec Machinery Directive

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 11 Appendix → 11.2 EC declaration of conformity in accordance with the EC Machinery Directive Version 03/2018, Rev. 1.5 of 09/03/2020 • sb-dc 93 / 107 Translation of the original operating manual...
  • Page 94 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 11 Appendix Version 03/2018, Rev. 1.5 of 09/03/2020 • sb-dc 94 / 107 Translation of the original operating manual...

  • Page 95: Declaration Of Conformity - China Rohs 2

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 11 Appendix Declaration of conformity – China RoHS 2 11.3 Version 03/2018, Rev. 1.5 of 09/03/2020 • sb-dc 95 / 107 Translation of the original operating manual...
  • Page 96 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 11 Appendix Version 03/2018, Rev. 1.5 of 09/03/2020 • sb-dc 96 / 107 Translation of the original operating manual...

  • Page 97: Ec Declaration Of Conformity In Accordance With The Pressure Equipment Directive

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 11 Appendix 11.4 EC declaration of conformity in accordance with the Pressure Equipment Directive Version 03/2018, Rev. 1.5 of 09/03/2020 • sb-dc 97 / 107 Translation of the original operating manual...
  • Page 98 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 11 Appendix Version 03/2018, Rev. 1.5 of 09/03/2020 • sb-dc 98 / 107 Translation of the original operating manual...

  • Page 99: Table Of The Sublimation Pressure Curve

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 11 Appendix 11.5 Table of the sublimation pressure curve °C = mbar °C = mbar °C = mbar °C = mbar 37.79 6.57 0.57 0.025 35.64 6.11 0.52 0.024 33.60 5.62 0.47 0.021...
  • Page 100 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 11 Appendix Version 03/2018, Rev. 1.5 of 09/03/2020 • sb-dc 100 / 107 Translation of the original operating manual...

  • Page 101: 12 Glossary

    12 Glossary Cold trap operation Cold traps are used for the condensation of moisture or solvents in combination with vacuum pumps. CHRIST freeze-dryers can be used as cold traps. Desorption Desorption (from Latin de-sorbere, sorbere = sup up, suck in) describes a phenomenon whereby molecules are released from the surface of a solid.
  • Page 102 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic 12 Glossary With the single-chamber method, the freezing as well as the subsequent drying of the product take place inside the ice condenser chamber. The sample is frozen as a result of the low temperature of the ice condenser (-55°C in the case of single-stage systems or -85°C in the case of double-...

  • Page 103: 13 Index

    Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic Index 13 Index Compliance with the EC health and safety directives ..........23 Access protection........58 Condensate, contaminated (hazards) .... Accessories ......12, 31, 74, 80 ..........29, 38, 71, 76 Accident prevention ........24 Connection..........
  • Page 104 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic Index Dialogue box "Process and equipment Freeze-dryer type ........64 messages ..........48 Freeze-dryer, cleaning and care ....75 Dialogue box "Schematic system diagram" 46 Freeze-drying of acid-containing products.. 11 Dialogue box "Tools" ........47 Freeze-drying of solvent-containing products Dimensions ..........
  • Page 105 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic Index Ice condenser chamber, cleaning and care 75 Max. humidity ..........85 Importance of the operating manual ..... 9 Maximum current for the vacuum pump ..40 Important information ......... 22 Measures to be taken to ensure safe operation ..........
  • Page 106 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic Index Potentially hazardous situation....22 Safety notes concerning the operation ..26 Power failure ..........69 Safety notes concerning the transport ..25 Power supply ..........37 Safety pressure ........101 Power supply of the pressure control valve 15 Safety-conscious work .......
  • Page 107 Freeze-dryer Beta 1-8 LSCbasic Freeze-dryer Beta 2-8 LSCbasic Index Table of the sublimation pressure curve ..99 Vacuum connection ......15, 85 Technical data ........... 84 Vacuum pump ..........40 Technical documentation ......85 Vacuum pump connection ......84 Thermal stress ........36, 74 Vacuum pump is not activated ....

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