Christ Gamma 1-16 LSCplus Operating Manual
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Christ Gamma 1-16 LSCplus Operating Manual

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Translation of the original operating manual
sb-dc
Freeze-dryer
Rev. 2.10 of 09/03/2020
Gamma 1-16 LSCplus;Freeze-dryer;Gamma 2-16 LSCplus
Version 04/2013
Gamma 1-16 LSCplus
Part no. 102210, 102212, 102214, 102216, 102218, 102220, 102226
Gamma 2-16 LSCplus
Part no. 102211, 102213, 102215, 102217, 102219, 102221, 102227
Operating Manual
Freeze-dryer
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  • Page 1 Translation of the original operating manual sb-dc Freeze-dryer Rev. 2.10 of 09/03/2020 Gamma 1-16 LSCplus;Freeze-dryer;Gamma 2-16 LSCplus Version 04/2013 Gamma 1-16 LSCplus Part no. 102210, 102212, 102214, 102216, 102218, 102220, 102226 Gamma 2-16 LSCplus Part no. 102211, 102213, 102215, 102217, 102219, 102221, 102227...
  • Page 2 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus Version 04/2013, Rev. 2.10 of 09/03/2020 • sb-dc 2 / 126 Translation of the original operating manual...
  • Page 3 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus In case of inquiries, please state the following numbers: Order number: Serial number: © Copyright by Martin Christ Gefriertrocknungsanlagen GmbH An der Unteren Söse 50 37520 Osterode am Harz Germany Tel.: +49 (0) 5522 / 5007-0...
  • Page 4 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus Version 04/2013, Rev. 2.10 of 09/03/2020 • sb-dc 4 / 126 Translation of the original operating manual...

  • Page 5: Table Of Contents

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus Table of contents General information ......................9 Importance of the operating manual .................. 9 Intended use ........................9 Warranty and liability....................... 11 Copyright ........................12 Explanation of symbols ....................12 Standards and regulations ....................12 Scope of supply ......................
  • Page 6 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus Table of contents 3.8.1 System check ......................31 3.8.2 Earth conductor check ....................31 Procedures in the event of hazards and accidents ............32 3.10 Maintenance and cleaning of the freeze-dryer ..............32 3.11...
  • Page 7 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus Table of contents Switching the freeze-dryer OFF ..................84 Malfunctions and error correction ..................85 General malfunctions ...................... 85 7.1.1 Power failure ......................86 7.1.2 Insufficient vacuum ....................87 7.1.2.1 Small flange connections ................... 87 7.1.2.2...
  • Page 8 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus Table of contents Version 04/2013, Rev. 2.10 of 09/03/2020 • sb-dc 8 / 126 Translation of the original operating manual...

  • Page 9: General Information

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 1 General information → General information → Importance of the operating manual A fundamental requirement for the safe and trouble-free operation of the unit is to be familiar with the fundamental safety instructions and all possible hazards.
  • Page 10 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 1 General information The following table can be used as a general guide for the expected degradation during normal freeze-drying processes of organic solvents with a total max. concentration of 10 vol-% in aqueous solutions.

  • Page 11: Warranty And Liability

    Any other use beyond this area of application is regarded as improper use. Martin Christ Gefriertrocknungsanlagen GmbH cannot be held liable for any damage resulting from such improper use.

  • Page 12: Copyright

    Freeze-dryer Gamma 2-16 LSCplus 1 General information → Copyright The copyright concerning the operating manual remains with Martin Christ Gefriertrocknungsanlagen GmbH. The operating manual is solely intended for the operator and their personnel. It includes instructions and information that may not be •...

  • Page 13: Layout And Mode Of Operation

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 2 Layout and mode of operation → Layout and mode of operation → Layout of the freeze-dryer → 2.1.1 Functional and operating elements Ice condenser chamber LSCplus user interface (see chapter 6.5.1 - "User interface")
  • Page 14 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 2 Layout and mode of operation Contact bolt Pipe connection of the vacuum pump (behind the cover plate) Ice condenser Pipe connection of the vacuum sensor Fig. 3: Ice condenser chamber Mains power switch Fig.
  • Page 15 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 2 Layout and mode of operation Aeration valve 10 Media drain valve Fig. 5: left side of the freeze-dryer 11 Serial interface 12 Electrical connection of the vacuum sensor 13 Name plate (see chapter 2.1.2 - "Name...

  • Page 16: Name Plate

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 2 Layout and mode of operation 2.1.2 Name plate Serial number Type Refrigerant data of the 1 stage Nominal voltage Year of manufacture (month/year) Part number Refrigerant data of the 2 stage...

  • Page 17: Mode Of Operation

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 2 Layout and mode of operation → Mode of operation → 2.2.1 General information on freeze-drying What is freeze-drying? Freeze-drying or lyophilisation is a procedure for the gentle drying of high- quality products. The product is dried by → sublimation without passing through the liquid phase.
  • Page 18 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 2 Layout and mode of operation Fig. 8: Vapour pressure curve for ice and water From a physical point of view, the freeze-drying process covers three phases (see figure below): (1) Freezing: The product to be dried is frozen under atmospheric pressure.
  • Page 19 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 2 Layout and mode of operation Fig. 9: Freeze-drying phases Please find further information about basic principles, optimum procedures and applications in the brochure "Smart freeze-drying", which can be downloaded at www.martinchrist.de → [Applications] →...

  • Page 20: Freeze-Drying Process

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 2 Layout and mode of operation → 2.2.2 Freeze-drying process The main components of a freeze-dryer are: • vacuum drying chamber or drying manifold, • vacuum pump for generating a vacuum inside the drying chamber, •...

  • Page 21: Main Drying

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 2 Layout and mode of operation 2.2.2.3 Main drying When the product is frozen, the main drying phase commences. The vacuum pump is switched on. The pressure inside the drying chamber will...

  • Page 22: Defrosting

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 2 Layout and mode of operation → 2.2.2.6 Defrosting Defrosting with hot gas As standard, the freeze-dryer is equipped with a hot-gas defrosting system. In order to defrost the ice condenser, heated refrigerant is fed through the heating coil.

  • Page 23: Safety

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 3 Safety → Safety → Marking of the unit The following symbols are used for Christ freeze-dryers: Dangerous voltage On (Power) Hot surface Off (Power) Name plate (see chapter Caution! Risk of bruising 2.1.2 - "Name plate")

  • Page 24: Explanation Of The Symbols And Notes

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 3 Safety → Explanation of the symbols and notes This operating manual uses the following names and symbols to indicate hazards: This symbol stands for a direct hazard to the life and health of persons.

  • Page 25: Responsibility Of The Operator

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 3 Safety → Responsibility of the operator Operating personnel The operator is obliged to ensure that the persons working on/with the freeze-dryer • are 18 years old or older, • have been specifically ordered to do so by the operator/owner and that...

  • Page 26: Operating Personnel

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 3 Safety → Operating personnel It must be ensured that persons operating the unit • are 18 years old or older, • have been specifically ordered to operate the unit and made aware of...

  • Page 27: General Hazards

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 3 Safety 3.6.1 General hazards General risk of injury Among the general hazards during the transport, set-up and connection and start-up of the freeze-dryer are impact hazards, crushing hazards, grazing hazards, cutting hazards, etc.

  • Page 28: Hazards Caused By Improper Connection

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 3 Safety 3.6.4 Hazards caused by improper connection Risk of injury caused by consequences of improper connection Improper connection may lead to a hazardous electrical incident at a later time during the operation of the freeze-dryer.

  • Page 29: Hazards Caused By The Refrigeration System (Non-Flammable Refrigerants)

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 3 Safety 3.7.2 Hazards caused by the refrigeration system (non-flammable refrigerants) Risk of poisoning caused by the refrigerant During its decomposition (e.g. due to naked flames or hot surfaces), hazardous/toxic gases are released.

  • Page 30: Hazards Caused By Solvents In The Products

    This may lead to severe injuries. DANGER Freeze-drying of products containing acids is only permissible if special protective measures and equipment-related precautions are taken! Consultation of Martin Christ Gefriertrocknungsanlagen GmbH is absolutely mandatory in order to define the measures that need to be taken! •...

  • Page 31: Hazards Caused By Cold Surfaces

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 3 Safety 3.7.8 Hazards caused by cold surfaces Risk of freezing to cold surfaces The ice condenser coils can already be cold during the loading phase. There is a risk of freezing to the ice condenser coils when touching the surfaces.

  • Page 32: Procedures In The Event Of Hazards And Accidents

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 3 Safety → Procedures in the event of hazards and accidents Hazardous electrical incident: • Set the control switch to the "0" position in order to interrupt the power supply completely. Fire: •...

  • Page 33: Measures To Be Taken To Ensure Safe Operation Of The Freeze-Dryer

    • Stop the freeze-dryer immediately in the event of a malfunction. Eliminate the malfunction (see chapter 7 - "Malfunctions and error correction") or contact the after-sales service of Firma Martin Christ Gefriertrocknungsanlagen GmbH (see chapter 7.3 - "Service contact"). •...

  • Page 34: Remaining Hazards

    → 3.12 Remaining hazards All Christ freeze-dryers were built state-of-the-art and according to the accepted safety rules. Danger to life and limb of the operator, or of third parties, or impairments of the units or other material assets, however, cannot be completely excluded when the units are being used.

  • Page 35: Storage And Transport

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 4 Storage and transport → Storage and transport → Dimensions and weight Values for the freeze-dryer without a vacuum pump: Gamma 1-16 LSCplus Gamma 2-16 LSCplus Height: 495 mm 495 mm Width:...

  • Page 36: Notes On Transport

    When lifting the freeze dryer, always reach under the freeze-dryer from the side. Do not grab the unit at the plastic control panel. The freeze-dryer Gamma 1-16 LSCplus weighs approx. 135 kg! The freeze-dryer Gamma 2-16 LSCplus weighs approx. 160 kg!

  • Page 37: Packaging

    • Lift the freeze-dryer upwards with a lifting device. Always reach under the unit from the side. The freeze-dryer Gamma 1-16 LSCplus weighs approx. 135 kg! The freeze-dryer Gamma 2-16 LSCplus weighs approx. 160 kg! CAUTION The centre of gravity of the freeze-dryer is off-centre! CAUTION •...

  • Page 38: Set-Up And Connection

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 5 Set-up and connection → Set-up and connection → Location of use Use the freeze-dryer solely in closed and dry spaces. Refrigeration problems of the freeze-dryer are often caused by insufficient conditions at the location of use. This is why compliance with the following...

  • Page 39: Power Supply

    The operating voltage on the name plate must correspond to the local supply voltage! DANGER Christ freeze-dryers are units of protection class I. Freeze-dryers of this type have a three-wire power cord with an IEC C13 connector (see chapter 10 - "Technical data").

  • Page 40: Media Drain Valve

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 5 Set-up and connection → Media drain valve Risk of poisoning/infection caused by contaminated condensate (defrosting water) The condensate may contain harmful substances originating from the product. WARNING Contact with the condensate may cause severe damage to health.

  • Page 41: Vacuum Pump

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 5 Set-up and connection • Take the vacuum sensor out of its original packaging and fasten it to the connector with a clamping ring (DIN16KF) and a centring ring (included in the scope of supply).

  • Page 42: Pressure Control Valve

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 5 Set-up and connection The vacuum pump is supplied with power by the unit, but the maximum current for the vacuum pump is limited. It is absolutely essential to refer to the label of the electrical outlet for the vacuum pump (see the following...

  • Page 43: Rubber Valves

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 5 Set-up and connection → Rubber valves The rubber valves (part no. 121860) enable the connection of round-bottom flasks, wide-neck filter bottles, or distributors for ampoules to a manifold or drying chamber. Depending on the connector of the components, the blue plug can be removed.

  • Page 44: Operation

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation Operation Initial start-up Before the initial start-up, please ensure that your freeze-dryer is properly set up and installed (see chapter 5 - "Set-up and connection") WARNING → Installation of accessories The accessories must be completed in accordance with the drying method that is applied as well as in accordance with the scope of supply.

  • Page 45: Lscplus Control System

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation LSCplus control system The control system LSCplus (Lyo Screen Control plus) was specifically developed for the control of freeze-drying processes. The clear user interface enables the intuitive operation of the unit.

  • Page 46: Main Window "Manual

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation The user interface is divided into four main windows that can be called up by touching the corresponding buttons: Manual This window is also the standard user interface. It is used to control the freeze-drying process manually.
  • Page 47 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation Status line (1) This line shows the operating status of the freeze-dryer as well as the active phase. The status line also shows the current date and time. The clock is battery- buffered and must be reset after a failure (chapter 6.5.1.3 - "Main window...
  • Page 48 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation Fig. 20: Dialog box "Select actual value" • Select the desired configuration or quit the dialog box by pressing the "return" button. In this way, it is possible to configure a personalised overview of the actual values.
  • Page 49 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation Option: USB process recording (see chapter 6.6 - "Optional extensions") • Select the "Process recording" function in the dialog box "Tools". • Select the input fields ("Batch data"). A keyboard for the data input will be displayed.
  • Page 50 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation Fig. 23: Dialog box “Pressure increase test” • The "Test stop" button stops the pressure increase test. Dialog box "Schematic system diagram" (6) Pressing the button "Schematic system diagram" displays a schematic diagram of the system on the left-hand side of the screen, including all the components.
  • Page 51 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation Dialog box "Process and equipment messages" (7) This dialog box shows and saves all of the error messages and other messages. In the event of an error or message, the window “Process and equipment messages”...
  • Page 52 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation Details Touching the message calls up details concerning the error message: • Cause of the message • Effects of the message • Measures to eliminate the error → Reference designator •...
  • Page 53 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation Dialog box "Operating mode: select/start" (8) After the set values have been entered for the process, the process can be started manually with this function (see chapter 6.5.2 - "Manual freeze- drying").
  • Page 54 Fig. 30: Results of the performance tests Evaluation: Please contact the Martin Christ Gefriertrocknungsanlagen GmbH for an assessment of the results. Version 04/2013, Rev. 2.10 of 09/03/2020 • sb-dc 54 / 126...
  • Page 55 • Select "Leakage test" and start the test via the "Run" button. The parameters for the leakage test have been developed by Martin Christ Gefriertrocknungsanlagen specifically for the freeze-dryers. In a first step, these parameters (vacuum, ice condenser temperature) must be reached.

  • Page 56: Main Window "Program

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation 6.5.1.2 Main window "Program" In the main window "Program", pre-programmed freeze-drying processes can be loaded and edited and new programs can be created with the PGMplus programmer module. For this function, the PGMplus programmer module must be available.

  • Page 57: Main Window "Options

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation 6.5.1.3 Main window "Options " The main window "Options" is used to perform fundamental basic settings of the control system in order to adapt it perfectly to the respective area of application of the freeze-dryer.
  • Page 58 • Double chamber method LyoCube (outside): drying outside the ice con- denser chamber, but with the CHRIST LyoCube (a rectangular drying chamber that can be loaded from the front) Fig. 35: Dialog box "Freeze-drying processes" Version 04/2013, Rev. 2.10 of 09/03/2020 • sb-dc...
  • Page 59 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation Administration “Administration” options: "Date/Time" "Network" "System properties" "Access protection" "Device options" "Configuration of sensors" Abb. 36: Dialogfenster "Optionen" / Verwaltung Date/Time (1) The LSC control system is equipped with an integrated, battery-buffered plus clock.
  • Page 60 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation Fig. 38: Dialog box "Network" System properties (3) This dialog box is used to change various system settings. Fig. 39: Dialog box "System properties" Beeper: The beeper sounds in the event of a malfunction, for example.
  • Page 61 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation Access protection (4) In this dialog box, the access rights can be managed on several levels and they can be protected with a password. In the factory setting with an activated access protection, data can be viewed but not edited.
  • Page 62 • Press the button "Add option". An input window opens. • Enter the six-digit Christ activation code that was supplied for this option. Note that the keys are case sensitive. Options can be removed in the same way. The modifications will not become effective until after a restart of the unit.
  • Page 63 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation Configuration of sensors (6) The sensor configurations depend on the equipment version of the unit. If the configuration is incorrect, the correct operation of the unit cannot be guaranteed. CAUTION This dialog box is used to configure the existing vacuum and pressure sensors.
  • Page 64 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation Service “Service” options: "Operating hours" "Failure memory" "Wireless shelf technology" "Vacuum pump oil change" "Maintenance" "Sensor adjustment" Fig. 45: Dialog box "Service" (varies depending on the type of system) Operating hours (1) This dialog box is used to call up the number of operating hours of the various components of the freeze-dryer, e.g.
  • Page 65 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation Failure memory (2) The failure memory stores the most recent messages of the process and equipment information system. These messages can be viewed in this dialog box. The failure memory includes the last 32 messages. If this number is exceeded, the oldest message will be overwritten.
  • Page 66 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation Fig. 48: Wireless shelf technology – assignment of shelf addresses • In order to assign an address, open the dialog box "Wireless Shelf Technology". • Ensure that only the WST module to which an address is to be assigned is connected.
  • Page 67 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation Maintenance (5) The maintenance interval of the unit is fixed at 3,000 operating hours or at least one maintenance per year. When the end of a maintenance interval is reached, a corresponding message will be displayed.

  • Page 68: Main Window

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation 6.5.1.4 Main window "?" This main window includes the most important information concerning your freeze-dryer: Freeze-dryer type Control system type Serial number Manufacturer contact data Details concerning the software version Fig.

  • Page 69: Entering Set Values In The Manual Mode

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation If in one section the value "∞" (infinite) is selected for a process phase, the next phase must be started manually via the button "Operating mode: select/start". NOTE In the manual mode, the set values of the active phase can be changed during the process run.
  • Page 70 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation Viewing or editing the set values: • Press the button "Set values: view/edit" (see chapter 6.5.1.1 - "Main window "Manual""). The following dialog box will be displayed: "Aeration" button "Defrosting" button "Media drain"...

  • Page 71: Option: Freeze-Drying With The Pgmplus Programmer Module

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation Numerical values can be edited with the aid of a numerical keypad: Set value display Button for changing the sign (e.g. when entering temperature values) "" (infinite) Button for editing the...
  • Page 72 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation Fig. 55: Representation of a freeze-drying program Program sections When the programmer module executes a freeze-drying process, it executes the various sections that were created one after the other until the last section is completed.
  • Page 73 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation Conditions for switching to the next section For all of the program sections to be executed automatically, certain switching conditions must be fulfilled at the end of each section. If these conditions are not fulfilled, e.g.
  • Page 74 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation Vacuum pump warm-up Apart from the execution of the various sections, the PGMplus programmer module also controls other tasks that need to be performed during the process run, e.g. the automatic activation of the vacuum pump.

  • Page 75: Creating A Program

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation 6.5.3.1 Creating a program To create a new program: • Press the button "New program" in the main window "Program". The dialog box that is displayed offers various different program templates.
  • Page 76 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation “Program” buttons: "Program" "Program name" "Show diagram " "Insert section " "Delete section " Button for calling up more functions and set values "Save" Fig. 59: Editing a blank program template •...
  • Page 77 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation Button ">>more" The button ">>more" can be used to enter more functions and set values in a program-related manner. Fig. 60: Selection of program-related functions and set values Vacuum pump warm-up See chapter 6.6 - "Optional extensions"...
  • Page 78 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation Otherwise, a process message will be issued, the current section will be extended, and further pressure increase tests will be executed periodically until the condition is fulfilled. If the actual value exceeds the set value before the preselected time has elapsed, the test will be aborted in order to prevent the product from thawing.
  • Page 79 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation Option: Comparative pressure measurement (see chapter 6.6 - "Optional extensions") The indication of the measurement value "dp Comp" can be configured in chapter 6.5.1.1 - "Main window "Manual""under "Actual values of the current process"...

  • Page 80: Editing A Program

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation Program templates (2) The PGMplus programmer module offers 14 different program templates that include recipes for all kinds of freeze-drying applications. They are suggestions for orientation purposes and must be adapted to the specific area of application of the freeze-dryer.

  • Page 81: Copying A Program

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation 6.5.3.3 Copying a program If a new program is to be created based on an already existing program, the already existing program can be copied. A free program storage location must be available for this purpose.

  • Page 82: Deleting A Program

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 6 Operation Fig. 65: The freeze-drying process can be started with the aid of the button “Program start”. • During the freeze-drying process, the description of the active program can also be called up from the main window "Program" and via the button "Info".

  • Page 83: Optional Extensions

    Since absolutely tight components simply do not exist, a leak rate is determined. The parameters for the leakage test have been developed by Martin Christ Gefrier- trocknungsanlagen specifically for freeze-dryers. In a first step, these parameters (vacuum, ice condenser temperature) must be reached.

  • Page 84: Switching The Freeze-Dryer Off

    LPCplus SCADA system The Christ LPCplus system consists of the Supervisory Control And Data Acquision (SCADA) software program by Martin Christ Gefriertrocknungs- anlagen GmbH and a dedicated PC. The system is connected to the...

  • Page 85: Malfunctions And Error Correction

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 7 Malfunctions and error correction → Malfunctions and error correction Malfunctions are displayed in the dialogue box "Process & equipment messages" (see chapter 7.2 - "Process and error messages"). An acoustic signal sounds when an error message is generated.

  • Page 86: Power Failure

    (see chapter 7.3 - "Service contact") If it is impossible to eliminate the errors, contact the Christ service department! NOTE → 7.1.1 Power failure The control system continues with the process after a power failure.

  • Page 87: Insufficient Vacuum

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 7 Malfunctions and error correction → 7.1.2 Insufficient vacuum The vacuum checks must be carried out when the ice condenser is frozen. NOTE → 7.1.2.1 Small flange connections Leakages are often due to improper small flange connections between the various components and hose connections or to leakages in the valves.

  • Page 88: Aeration Valve, Media Drain Valve

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 7 Malfunctions and error correction → 7.1.2.2 Aeration valve, media drain valve Risk of poisoning/infection caused by contaminated condensate (defrosting water) The condensate may contain harmful substances originating from the product. WARNING Contact with the condensate may cause severe damage to health.

  • Page 89: Insufficient Ice Condenser Temperature

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 7 Malfunctions and error correction → 7.1.3 Insufficient ice condenser temperature Ensure sufficient ventilation. Do not place any paper, cloth, or similar material behind or under the unit, since otherwise the air circulation will be impaired.

  • Page 90: Service Contact

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 7 Malfunctions and error correction → Service contact In the event of queries, malfunctions, or spare part enquiries: From Germany: Contact Martin Christ Gefriertrocknungsanlagen GmbH An der Unteren Söse 50 37520 Osterode (Germany) Tel.

  • Page 91: Maintenance And Service

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 8 Maintenance and service → Maintenance and service The freeze-dryer and the accessories are subject to high mechanical and chemical stress. Thorough maintenance performed by the user extends the service life and prevents premature failure.

  • Page 92: Ice Condenser Chamber

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 8 Maintenance and service Cleaning of the freeze-dryer • Switch the freeze-dryer off by actuating the mains power switch and disconnect the power cord from the wall outlet before cleaning. • If the freeze-dryer has been contaminated with toxic, radioactive, or...

  • Page 93: Aeration Valve, Media Drain Valve

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 8 Maintenance and service → 8.1.3 Aeration valve, media drain valve Risk of poisoning/infection caused by contaminated condensate (defrosting water) The condensate may contain harmful substances originating from the product. WARNING Contact with the condensate may cause severe damage to health.

  • Page 94: Heat Exchanger (Only For Air-Cooled Freeze-Dryers)

    • Check the heat exchanger at least once per month for soiling and clean it if necessary. • Please contact the Christ service department if you have any queries (see chapter 7.3 - "Service contact"). 8.1.5 Electrical system Danger of life caused by electric shock There is a risk of electric shock when touching current-carrying components.

  • Page 95: Exhaust Filter (Oil Mist Separator)

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 8 Maintenance and service → 8.1.7 Exhaust filter (oil mist separator) Please refer to the separate operating manual of the vacuum pump and the exhaust filter! NOTE The oil mist that is emitted by the vacuum pump in quantities that depend on the working pressure must be led to the outside or to an exhaust hood or similar.

  • Page 96: Vacuum Sensor

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 8 Maintenance and service → 8.1.9 Vacuum sensor Please refer to the separate operating manual of the vacuum sensor! NOTE The vacuum sensor has only a limited service life. Especially carbon- containing substances, e.g. alcoholic compounds, reduce the service life extremely.

  • Page 97: Disinfection Of The Drying Chamber And Accessories

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 8 Maintenance and service → Disinfection of the drying chamber and accessories If dangerous materials (e.g. infectious and pathogenic substances) are used, the freeze-dryer and accessories must be disinfected. DANGER  •...

  • Page 98: Service

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 8 Maintenance and service Service In the event of service work that requires the removal of the panels, there is a risk of electric shock or mechanical injury. Only qualified specialist personnel is authorised to perform this service work.
  • Page 99 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 8 Maintenance and service 1. Declaration of decontamination As a certified company and due to the legal regulations for the protection of our employees and of the environment, we are obliged to certify the harmlessness of all incoming goods.

  • Page 100: Disposal

    Freeze-dryer Gamma 2-16 LSCplus 9 Disposal → Disposal → Disposal of the freeze-dryer Martin Christ Gefriertrocknungsanlagen GmbH is a registered manufacturer of electric and electronic devices that are solely intended for commercial use. • Comply with all local rules and regulations. →...

  • Page 101: 10 Technical Data

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 10 Technical data → 10 Technical data Manufacturer: Martin Christ Gefriertrocknungsanlagen GmbH An der Unteren Söse 50 37520 Osterode (Germany) Type: Gamma 1-16 LSCplus Gamma 2-16 LSCplus Part number: 102210 102211 Performance data...
  • Page 102 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 10 Technical data Connection requirements Gamma 1-16 LSCplus Gamma 2-16 LSCplus (without vacuum pump and accessories) Mains fuse: 10 A 12 A Vacuum pump connection: 230 V, 50/60Hz, 6.5 A max. 230 V, 50/60 Hz, 4.5 A max.

  • Page 103: Ambient Conditions

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 10 Technical data → 10.1 Umgebungs beding ung en 10.1 Ambient conditions → 10.1 Umgebungs beding ung en • Use in closed spaces • Altitudes up to 2,000 m • Ambient temperature between +5°C and +25°C •...

  • Page 104: 11 Appendix

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 11 Appendix → 11 Appendix → 11.1 Mathematical relations The automatic processes in the “Programmer module” menu (see chapter 6.5.3 - "Option: freeze-drying with the PGMplus programmer module") are based on the following considerations: T/°C...

  • Page 105: Brief Operating Instructions

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 11 Appendix → 11.2 Brief operating instructions Functional and operating elements: Ice condenser chamber LSCplus user interface Fig. 72: Total view of the freeze-dryer Touchpanel Fig. 73: User interface with touchpanel Version 04/2013, Rev. 2.10 of 09/03/2020 • sb-dc...
  • Page 106 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 11 Appendix Contact bolt Pipe connection of the vacuum pump (behind the cover plate) Ice condenser Vacuum sensor Fig. 74: Ice condenser chamber Mains power switch Fig. 75: Right side of the freeze-dryer Version 04/2013, Rev.
  • Page 107 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 11 Appendix Aeration valve 10 Media drain valve Fig. 76: left side of the freeze-dryer 11 Serial interface 12 Electrical connection of the vacuum sensor 13 Name plate 14 Heat exchanger of the...
  • Page 108 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 11 Appendix Status line Set process values Button "Set values: view/edit" Actual values of the current process Button "Tools" Button "Schematic system diagram" Button "Process and equipment messages" Button "Operating mode: select/start"...
  • Page 109 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 11 Appendix The vacuum pump always runs with maximum power. With this type of freeze-dryer, the power of the vacuum pump cannot be controlled. NOTE 12 The operating panel displays the vacuum, the ice condenser temperature, and the current operating mode.
  • Page 110 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 11 Appendix 6 Connect a frozen sample to a valve. After the pressure has fallen below 1.030 mbar, a frozen sample can be connected to a valve. The next frozen sample cannot be connected to another valve until the pressure is again lower than 1.030 bar.

  • Page 111: Ec Declaration Of Conformity In Accordance With The Ec Machinery Directive

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 11 Appendix → 11.3 EC declaration of conformity in accordance with the EC Machinery Directive Version 04/2013, Rev. 2.10 of 09/03/2020 • sb-dc 111 / 126 Translation of the original operating manual...
  • Page 112 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 11 Appendix Version 04/2013, Rev. 2.10 of 09/03/2020 • sb-dc 112 / 126 Translation of the original operating manual...

  • Page 113: Declaration Of Conformity - China Rohs 2

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 11 Appendix Declaration of conformity – China RoHS 2 11.4 Version 04/2013, Rev. 2.10 of 09/03/2020 • sb-dc 113 / 126 Translation of the original operating manual...
  • Page 114 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 11 Appendix Version 04/2013, Rev. 2.10 of 09/03/2020 • sb-dc 114 / 126 Translation of the original operating manual...

  • Page 115: Ec Declaration Of Conformity In Accordance With The Pressure Equipment Directive

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 11 Appendix 11.5 EC declaration of conformity in accordance with the Pressure Equipment Directive Version 04/2013, Rev. 2.10 of 09/03/2020 • sb-dc 115 / 126 Translation of the original operating manual...
  • Page 116 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 11 Appendix Version 04/2013, Rev. 2.10 of 09/03/2020 • sb-dc 116 / 126 Translation of the original operating manual...

  • Page 117: Table Of The Sublimation Pressure Curve

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 11 Appendix 11.6 Table of the sublimation pressure curve °C = mbar °C = mbar °C = mbar °C = mbar 37.79 6.57 0.57 0.025 35.64 6.11 0.52 0.024 33.60 5.62 0.47 0.021...
  • Page 118 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 11 Appendix Version 04/2013, Rev. 2.10 of 09/03/2020 • sb-dc 118 / 126 Translation of the original operating manual...

  • Page 119: 12 Glossary

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus 12 Glossary 12 Glossary Comparative pressure measurement During the sublimation, i.e. when the concentration of water vapour molecules is rather high in the atmosphere, the value that is provided by the gas-type dependent vacuum sensor of the "Pirani" type (e.g. Thyracont VSP 62/63) deviates from the value that is provided by a capacitive vacuum sensor (e.g.
  • Page 120 Wireless Shelf Technology With the Wireless Shelf Technology (WST), Martin Christ Gefrier- trocknungsanlagen GmbH has developed a system for laboratory freeze- dryers that works without cable connections at the electrically heated shelves and other equipment parts.

  • Page 121: 13 Index

    Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus Index 13 Index Click on touch ..........60 Commissioning .......... 12 Access protection........61 Comparative pressure measurement ..... Accessories ......12, 33, 91, 96 ..........79, 83, 119 Accident prevention ........26 Compatibility test........
  • Page 122 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus Index Declaration of decontamination ....99 Electricity (hazards) ....... 28, 39, 94 Decontamination agents ......97 EMC according to EN 55011 ....102 Defrosting ..........22, 69 End of drying and aeration ......21 Defrosting water, contaminated (hazards) ..
  • Page 123 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus Index Hazards (contaminated defrosting water) ..Leakage test ........55, 69, 83 ..........30, 40, 88, 93 Loading a program ........81 Hazards (electricity) ....... 28, 39, 94 Location of use .......... 38 Hazards (general, transport to LPCplus SCADA system ......
  • Page 124 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus Index Network ............. 59 Power supply of the vacuum pump ..15, 107 Network drive ..........47 Preparation .......... 20, 44 New program ..........56 Pressure control valve ....... 42 No indication on the display ....... 85 Pressure control valve, malfunction ...
  • Page 125 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus Index Safety notes concerning the transport ..26 Safety pressure ........120 Table of the sublimation pressure curve ... 117 Safety-conscious work ....... 25 Technical data ......... 101 Schematic system diagram ......50 Technical documentation ......
  • Page 126 Freeze-dryer Gamma 1-16 LSCplus Freeze-dryer Gamma 2-16 LSCplus Index Weight ..........35, 102 Wireless shelf technology ....65, 120 Year of manufacture ........16 Version 04/2013, Rev. 2.10 of 09/03/2020 • sb-dc 126 / 126 Translation of the original operating manual...

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