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Christ Delta 1-4 LSCplus Operating Manual

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Translation of the original operating manual
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Freeze-dryer
Rev. 2.4 of 20/10/2017
Delta 1-4 LSCplus;Freeze-dryer;Delta 2-24 LSCplus
Version 04/2013
Part no. 102300, 102302, 102304, 102306, 102308, 102310, 102316, 102318, 102320, 102322
Part no. 102301, 102303, 102305, 102307, 102309, 102311, 102317, 102319, 102321, 102323
Delta 1-4 LSCplus
Delta 2-24 LSCplus
Freeze-dryer
Operating Manual
Please retain for later use!

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Summary of Contents for Christ Delta 1-4 LSCplus

  • Page 1 Translation of the original operating manual Freeze-dryer Rev. 2.4 of 20/10/2017 Delta 1-4 LSCplus;Freeze-dryer;Delta 2-24 LSCplus Version 04/2013 Delta 1-4 LSCplus Part no. 102300, 102302, 102304, 102306, 102308, 102310, 102316, 102318, 102320, 102322 Delta 2-24 LSCplus Part no. 102301, 102303, 102305, 102307, 102309, 102311, 102317, 102319, 102321, 102323...
  • Page 2 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus Version 04/2013, Rev. 2.4 of 20/10/2017 • sb 2 / 131 Translation of the original operating manual...
  • Page 3 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus In case of inquiries, please state the following numbers: Order number: Serial number: © Copyright by Martin Christ Gefriertrocknungsanlagen GmbH An der Unteren Söse 50 37520 Osterode am Harz Germany Tel.: +49 (0) 5522 / 5007-0...
  • Page 4 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus Version 04/2013, Rev. 2.4 of 20/10/2017 • sb 4 / 131 Translation of the original operating manual...

  • Page 5: Table Of Contents

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus Table of contents General information ......................9 Importance of the operating manual .................. 9 Intended use ........................9 Warranty and liability....................... 10 Copyright ........................10 Explanation of symbols ....................10 Standards and regulations ....................10 Scope of supply ......................
  • Page 6 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus Table of contents Storage and transport ....................... 30 Dimensions and weight ....................30 Storage conditions ......................30 Notes on transport ......................30 Packaging ........................31 Transport safety devices ....................31 On-site transport ......................32 Set-up and connection ......................
  • Page 7 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus Table of contents Malfunctions and error correction ..................79 General malfunctions ...................... 79 7.1.1 Power failure ......................80 7.1.2 Insufficient vacuum ....................81 7.1.2.1 Small flange connections ................... 81 7.1.2.2 Aeration valve, media drain valve ..............82 7.1.2.3...
  • Page 8 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus Table of contents Version 04/2013, Rev. 2.4 of 20/10/2017 • sb 8 / 131 Translation of the original operating manual...

  • Page 9: General Information

    In addition, the local rules and regulations for the prevention of accidents must be complied with.  Intended use CHRIST freeze-dryers have been solely designed for the freeze-drying of solid or liquid products in ampoules, vials or dishes. They are, therefore, solely intended for these applications. The freeze-dryer is suitable •...

  • Page 10: Warranty And Liability

     Copyright The copyright concerning the operating manual remains with Martin Christ Gefriertrocknungsanlagen GmbH. The operating manual is solely intended for the operator and their personnel. It includes instructions and information that may not be •...

  • Page 11: Layout And Mode Of Operation

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 2 Layout and mode of operation  Layout and mode of operation  Layout of the freeze-dryer  2.1.1 Functional and operating elements 1 LSCplus user interface (see chapter 6.5.1 - "User interface") 2...
  • Page 12 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 2 Layout and mode of operation 5 Contact bolt 6 Pipe connection of the vacuum pump (behind the cover plate) 7 Ice condenser 8 Vacuum sensor Fig. 3: Ice condenser chamber 9...
  • Page 13 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 2 Layout and mode of operation 11 Aeration valve 12 Media drain valve 13 Fixed castors Fig. 5: Left side of the freeze-dryer 14 Vacuum sensor 15 Mains voltage (Main switch) 16 Electrical connection of...

  • Page 14: Name Plate

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 2 Layout and mode of operation  2.1.2 Name plate 1 Serial number 2 Type 3 Refrigerant data of the 1 stage 4 Nominal voltage 5 Year of manufacture (month/year) 6 Part number 7...

  • Page 15: Mode Of Operation

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 2 Layout and mode of operation  Mode of operation  2.2.1 General information on freeze-drying What is freeze-drying? Freeze-drying or lyophilisation is a procedure for the gentle drying of high- quality products. The product is dried by  sublimation without passing through the liquid phase.
  • Page 16 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 2 Layout and mode of operation Pressure (mbar) LIQUID Melting SOLID 6.11 mbar Triple point Sublimation 0.37 mbar GASEOUS Temperature (°C) -30°C Fig. 8: Vapour pressure curve above ice From a physical point of view, the freeze-drying process covers three phases (see figure below): (1) Freezing: The product to be dried is frozen under atmospheric pressure.
  • Page 17 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 2 Layout and mode of operation Pressure (mbar) LIQUID 1 bar SOLID Triple point GASEOUS 20°C Temperature (°C) Fig. 9: Freeze-drying phases Please find further information about basic principles, optimum procedures and applications in the brochure "Smart freeze-drying", which can be downloaded at www.martinchrist.de ...

  • Page 18: Freeze-Drying Process

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 2 Layout and mode of operation  2.2.2 Freeze-drying process The main components of a freeze-dryer are: • vacuum drying chamber with a temperature control system for adding thermal energy • vacuum pump for generating a vacuum inside the drying chamber •...

  • Page 19: Main Drying

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 2 Layout and mode of operation Fig. 10: Shell freezing Fig. 11: Cooling bath with spin freezing device Fig. 12: Spin freezing If the product that is to be dried contains solvents or high salt concentrations, it may start to thaw during the drying process, which is indicated by clearly visible foaming.

  • Page 20: Final Drying

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 2 Layout and mode of operation 2.2.2.4 Final drying Final drying is an option whenever one requires a product with minimal residual moisture. In the physical sense, this process is a desorption process, i.e.
  • Page 21 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 2 Layout and mode of operation  Special equipment: defrosting with hot water For hot-water defrosting, the freeze-dryer must be connected to a hot water supply. NOTE The ice condenser is defrosted by feeding hot water into the ice condenser chamber.

  • Page 22: Safety

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 3 Safety  Safety  Marking of the unit The following symbols are used for CHRIST freeze-dryers: Dangerous voltage On (Power) Hot surface Off (Power) Name plate (see chapter Caution! Risk of bruising 2.1.2 - "Name plate")

  • Page 23: Explanation Of The Symbols And Notes

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 3 Safety  Explanation of the symbols and notes This operating manual uses the following names and symbols to indicate hazards: This symbol stands for a direct hazard to the life and health of persons.

  • Page 24: Responsibility Of The Operator

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 3 Safety  Responsibility of the operator The operator is obliged to ensure that the persons working with the freeze- dryer • are 18 years old or older, • have been specifically ordered to do so by the operator and that they...

  • Page 25: Informal Safety Instructions

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 3 Safety  Informal safety instructions This operating manual is a part of the product. • The operating manual must be kept at the location of use of the freeze- dryer. Ensure that it is accessible at all times.

  • Page 26: Electrical Safety

    3 Safety  3.6.1 Electrical safety CHRIST freeze-dryers are units of safety class I. Please comply with the following points in order to preserve the safety features: • Ensure that the local mains voltage matches the nominal voltage that is stated on the name plate.

  • Page 27: Fire Prevention

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 3 Safety  3.6.3 Fire prevention Fuses protect certain electrical circuits within the freeze-dryer against over- current conditions. • Always use fuses of the same type and rating. • Do not dry explosive or inflammable substances.

  • Page 28: Safety Devices

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 3 Safety Safety devices  3.7.1 System check An internal system check system monitors the data transfer and sensor signals with regard to plausibility. Errors are detected by continuous self- monitoring of the system. Error messages are displayed in the main window under "Process &...

  • Page 29: Remaining Hazards

    3 Safety  Remaining hazards All CHRIST freeze-dryers were built state-of-the-art and according to the accepted safety rules. Danger to life and limb of the operator, or of third parties, or impairments of the units or other material assets, however, cannot be completely excluded when the units are being used.

  • Page 30: Storage And Transport

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 4 Storage and transport  Storage and transport  Dimensions and weight Values for the freeze-dryer without a vacuum pump: Delta 1-24 LSCplus Delta 2-24 LSCplus Height: 1.090 mm 1.090 mm Width:...

  • Page 31: Packaging

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 4 Storage and transport  Packaging The freeze-dryer is packaged in a wooden crate. • After opening the packaging, take out the accessories. • Remove the packaging material. • Remove the side walls of the crate.

  • Page 32: On-Site Transport

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 4 Storage and transport  On-site transport The freeze-dryer comes with castors. It can be pushed by a suitable number of persons over short distances. Over longer distances, it should be transported by way of suitable lifting equipment (e.g. forklift truck).

  • Page 33: Set-Up And Connection

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 5 Set-up and connection  Set-up and connection  Installation site Operate the freeze-dryer only in closed and dry rooms. Refrigeration problems of the freeze-dryer are often caused by insufficient conditions at the location of use. This is why compliance with the following...

  • Page 34: Power Supply

    Work on the power supply system must only be performed by certified electricians. WARNING CHRIST freeze-dryers are units of safety class I.The freeze-dryers of the type Delta 1-24 LSCplus and Delta 2-24 LSCplus have a five-wire power cord with a 5-pin Cekon-plug (see chapter 10 - "Technical data").

  • Page 35: Media Drain Valve

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 5 Set-up and connection  Media drain valve The media drain valve is located at the bottom of the left side of the unit (see chapter 2.1.1 - "Functional and operating elements").
  • Page 36 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 5 Set-up and connection It is absolutely essential to comply with the manufacturer’s instructions in the separate operating manual of the vacuum sensor! NOTE Thyracont VCP63 (Pirani) Pfeiffer CMR 363 (capacitive) Fig. 16: Vacuum sensors of different manufacturers The vacuum sensor comes supplied in a calibrated state.

  • Page 37: Vacuum Pump

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 5 Set-up and connection 5.4.6 Vakuumpumpe  Vacuum pump Please refer to the separate operating manual of the vacuum pump and the exhaust filter! NOTE The vacuum pump must be connected to the vacuum connector of the unit.

  • Page 38: Rubber Valves

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 5 Set-up and connection  Rubber valves The rubber valves (part no. 121860) enable the connection of round-bottom flasks, wide-neck filter bottles, or distributors for ampoules to a manifold or drying chamber. Depending on the connector of the components, the blue plug can be removed.

  • Page 39: Operation

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation Operation Initial start-up Before the initial start-up, please ensure that your freeze-dryer is properly set up and installed (see chapter 5 - "Set-up and connection") WARNING  Installation of accessories The accessories must be completed in accordance with the drying method that is applied as well as in accordance with the scope of supply.

  • Page 40: Lscplus Control System

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation LSCplus control system The control system LSCplus (Lyo Screen Control plus) was specifically developed for the control of freeze-drying processes. The clear user interface enables the intuitive operation of the unit.

  • Page 41: Main Window "Manual

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation The user interface is divided into four main windows that can be called up by touching the corresponding buttons: Manual This window is also the standard user interface. It is used to control the freeze-drying process manually.
  • Page 42 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation Status line (1) This line shows the operating status of the freeze-dryer as well as the active phase. The status line also shows the current date and time. The clock is battery- buffered and must be reset after a failure (chapter 6.5.1.3 - "Main window...
  • Page 43 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation Actual values of the current process (4) This area shows the current process data. The fields can be configured as desired: • Select the button of the field that is to be adapted. A dialog box opens: Fig.
  • Page 44 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation Option: USB process recording (see chapter 6.6 - "Optional extensions") • Select the "Process recording" function in the dialog box "Tools". • Select the input fields ("Batch data"). A keyboard for the data input will be displayed.
  • Page 45 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation Fig. 25: Dialog box “Pressure increase test” • The "Test stop" button stops the pressure increase test. Dialog box "Schematic system diagram" (6) Pressing the button "Schematic system diagram" displays a schematic diagram of the system on the left-hand side of the screen, including all the components.
  • Page 46 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation Dialog box "Process and equipment messages" (7) This dialog box shows and saves all of the error messages and other messages. In the event of an error or message, the window “Process and equipment messages”...
  • Page 47 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation Details Touching the message calls up details concerning the error message: • Cause of the message • Effects of the message • Measures to eliminate the error  Reference designator •...
  • Page 48 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation Dialog box "Operating mode: select/start" (8) After the set values have been entered for the process, the process can be started manually with this function (see chapter 6.5.2 - "Manual freeze- drying").
  • Page 49 Final vacuum after 2 h xxx mbar Evaluation: Please contact the Martin Christ Gefriertrocknungsanlagen GmbH for an assessment of the results.. Button "Stop" (9) Pressing this button stops the current process. The system switches to the standby status.

  • Page 50: Main Window "Program

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation 6.5.1.2 Main window "Program" In the main window "Program", pre-programmed freeze-drying processes can be loaded and edited and new programs can be created with the PGMplus programmer module. For this function, the PGMplus programmer module must be available.

  • Page 51: Main Window "Options

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation 6.5.1.3 Main window "Options " The main window "Options" is used to perform fundamental basic settings of the control system in order to adapt it perfectly to the respective area of application of the freeze-dryer.
  • Page 52 • Double chamber method LyoCube (outside): drying outside the ice condenser chamber, but with the CHRIST LyoCube (a rectangular drying chamber that can be loaded from the front) Fig. 36: Dialog box "Freeze-drying processes" Version 04/2013, Rev. 2.4 of 20/10/2017 • sb...
  • Page 53 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation Administration “Administration” options: "Date/Time" "Network" "System properties" "Access protection" "Device options" "Configuration of sensors" Abb. 37: Dialogfenster "Optionen" / Verwaltung Date/Time (1) The LSC control system is equipped with an integrated, battery-buffered plus clock.
  • Page 54 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation Network (2) This dialog box is used to change various system settings. The modifications will not become effective until after a restart of the unit. NOTE Fig. 39: Dialog box "Network"...
  • Page 55 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation Behaviour of the pressure control valve in the case of insufficient ice condenser cooling: If this function is active (button "closed"), the pressure control valve will close at an ice condenser temperature of ≥...
  • Page 56 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation • The button with the lock symbol blocks the access immediately and the system switches to the default setting. Fig. 43: Access blocked, the data cannot be edited User/maintenance/administrator password: For each of these access levels, certain editing rights have been defined.
  • Page 57 • Press the button "Add option". An input window opens. • Enter the six-digit Christ activation code that was supplied for this option. Note that the keys are case sensitive. Options can be removed in the same way. The modifications will not become effective until after a restart of the unit.
  • Page 58 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation Service “Service” options: 1 "Operating hours" 2 "Failure memory" 3 "Wireless shelf technology" 4 "Vacuum pump oil change" 5 "Maintenance" 6 "Sensor adjustment" Fig. 46: Dialog box "Service" (varies depending on the type of system)
  • Page 59 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation Always indicate the error code in the event of enquiries or service requests! NOTE Fig. 48: Dialog box "Failure memory" Wireless shelf technology (3) This function depends on the unit type and is not available for all types of freeze-dryers.
  • Page 60 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation • In order to assign an address, open the dialog box "Wireless Shelf Technology". • Ensure that only the WST module to which an address is to be assigned is connected. If several modules are connected, they will all receive the same address, resulting in a communication conflict.
  • Page 61 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation Fig. 51: Dialog box "Maintenance" Sensor adjustment (6) Misadjusted sensors will lead to incorrect measurement values, which in turn will have a negative effect on the process control. CAUTION In this dialog box, the sensors are adjusted in terms of a predefined reference value.

  • Page 62: Main Window

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation 6.5.1.4 Main window "?" This main window includes the most important information concerning your freeze-dryer: Freeze-dryer type Control system type Serial number Manufacturer contact data Details concerning the software version Fig.

  • Page 63: Entering Set Values In The Manual Mode

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation If in one section the value "∞" (infinite) is selected for a process phase, the next phase must be started manually via the button "Operating mode: select/start". NOTE In the manual mode, the set values of the active phase can be changed during the process run.
  • Page 64 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation Viewing or editing the set values: • Press the button "Set values: view/edit" (see chapter 6.5.1.1 - "Main window "Manual""). The following dialog box will be displayed: "Aeration" button 2...

  • Page 65: Option: Freeze-Drying With The Pgmplus Programmer Module

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation Numerical values can be edited with the aid of a numerical keypad: Set value display Button for changing the sign (e.g. when entering temperature values) "" (infinite) Button for editing the...
  • Page 66 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation Fig. 57: Representation of a freeze-drying program Program sections When the programmer module executes a freeze-drying process, it executes the various sections that were created one after the other until the last section is completed.
  • Page 67 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation Conditions for switching to the next section For all of the program sections to be executed automatically, certain switching conditions must be fulfilled at the end of each section. If these conditions are not fulfilled, e.g.
  • Page 68 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation Vacuum pump warm-up Apart from the execution of the various sections, the PGMplus programmer module also controls other tasks that need to be performed during the process run, e.g. the automatic activation of the vacuum pump.

  • Page 69: Creating A Program

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation 6.5.3.1 Creating a program To create a new program: • Press the button "New program" in the main window "Program". The dialog box that is displayed offers various different program templates.
  • Page 70 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation “Program” buttons: "Program" "Program name" "Show diagram " "Insert section " "Delete section " Button for calling up more functions and set values "Save" Fig. 61: Editing a blank program template •...
  • Page 71 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation Fig. 62: Selection of program-related functions and set values Vacuum pump warm-up See chapter 6.6 - "Optional extensions"  Option: Pressure increase test (only with the double chamber method) (see chapter 6.6 - "Optional extensions") The ...
  • Page 72 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation periodically until the condition is fulfilled. If the actual value exceeds the set value before the preselected time has elapsed, the test will be aborted in order to prevent the product from thawing. If the value is exceeded, the pressure increase test will be aborted in order to prevent the product from thawing.
  • Page 73 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation Option: Comparative pressure measurement (see chapter 6.6 - "Optional extensions") The indication of the measurement value "dp Comp" can be configured in chapter 6.5.1.1 - "Main window "Manual"" under "Actual values of the current process"...

  • Page 74: Editing A Program

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation Program templates (2) The PGMplus programmer module offers 14 different program templates that include recipes for all kinds of freeze-drying applications. They are suggestions for orientation purposes and must be adapted to the specific area of application of the freeze-dryer.

  • Page 75: Copying A Program

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation 6.5.3.3 Copying a program If a new program is to be created based on an already existing program, the already existing program can be copied. A free program storage location must be available for this purpose.

  • Page 76: Deleting A Program

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 6 Operation Fig. 67: The freeze-drying process can be started with the aid of the button “Program start”. • During the freeze-drying process, the description of the active program can also be called up from the main window "Program" and via the button "Info".

  • Page 77: Optional Extensions

    Since absolutely tight components simply do not exist, a leak rate is determined. The parameters for the leakage test have been developed by Martin Christ Gefrier- trocknungsanlagen specifically for freeze-dryers. In a first step, these parameters (vacuum, ice condenser temperature) must be reached.

  • Page 78: Switching The Freeze-Dryer Off

    LPCplus SCADA system The Christ LPCplus system consists of the Supervisory Control And Data Acquision (SCADA) software program by Martin Christ Gefriertrocknungs- anlagen GmbH and a dedicated PC. The system is connected to the...

  • Page 79: Malfunctions And Error Correction

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 7 Malfunctions and error correction  Malfunctions and error correction Malfunctions are displayed in the dialog box "Process & equipment messages" (see chapter 7.2 - "Process and error messages"). An acoustic signal sounds when an error message is generated.

  • Page 80: Power Failure

    • The thermal circuit breaker has Ensure sufficient air circulation tripped. (see chapter 7.1.3 - "Insufficient ice condenser temperature") If it is impossible to eliminate the errors, contact the Christ service department! NOTE  7.1.1 Power failure The control system continues with the process after a power failure. The preselected conditions remain saved even during a process run.

  • Page 81: Insufficient Vacuum

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 7 Malfunctions and error correction  7.1.2 Insufficient vacuum The vacuum checks must be carried out when the ice condenser is frozen. NOTE  7.1.2.1 Small flange connections Leakages are often due to improper small flange connections between the various components and hose connections or to leakages in the valves.

  • Page 82: Aeration Valve, Media Drain Valve

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 7 Malfunctions and error correction  7.1.2.2 Aeration valve, media drain valve A malfunction of the aeration valve or the media drain valve may have several causes. One potential source are contaminants such as product residues within the valve.

  • Page 83: Insufficient Ice Condenser Temperature

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 7 Malfunctions and error correction  7.1.3 Insufficient ice condenser temperature Ensure sufficient ventilation. Do not place any paper, cloth, or similar material behind or under the unit, since otherwise the air circulation will be impaired.

  • Page 84: Service Contact

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 7 Malfunctions and error correction  Service contact In the event of queries, malfunctions, or spare part enquiries: From Germany: Contact Martin Christ Gefriertrocknungsanlagen GmbH An der Unteren Söse 50 37520 Osterode (Germany) Tel.

  • Page 85: Maintenance And Service

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 8 Maintenance and service  Maintenance and service The freeze-dryer and the accessories are subject to high mechanical stress. Thorough maintenance performed by the user extends the service life and prevents premature failure.

  • Page 86: Ice Condenser Chamber

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 8 Maintenance and service Cleaning of the freeze-dryer • Switch the freeze-dryer off by actuating the mains power switch and disconnect the power cord from the wall outlet before cleaning. • If the freeze-dryer has been contaminated with toxic, radioactive, or...

  • Page 87: Heat Exchanger (Only For Air-Cooled Freeze-Dryers)

    This is why the selected set-up location should be as clean as possible. • Check the heat exchanger at least once per month for soiling and clean it if necessary. • Please contact the Christ service department if you have any queries (see chapter 7.3 - "Service contact").  8.1.5 Vacuum pump...

  • Page 88: Exhaust Filter (Oil Mist Separator)

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 8 Maintenance and service  8.1.6 Exhaust filter (oil mist separator) Please refer to the separate operating manual of the vacuum pump and the exhaust filter! NOTE The oil mist that is emitted by the vacuum pump in quantities that depend on the working pressure must be led to the outside or to an exhaust hood or similar.

  • Page 89: Disinfection Of The Drying Chamber And Accessories

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 8 Maintenance and service • Check the material regularly (at least once a month) for – cracks – visible damage of the surface – pressure marks – signs of corrosion – other changes.

  • Page 90: Service

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 8 Maintenance and service Service In the event of service work that requires the removal of the panels, there is a risk of electric shock or mechanical injury. Only qualified specialist personnel is authorised to perform this service work.
  • Page 91 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 8 Maintenance and service 1. Declaration of decontamination As a certified company and due to the legal regulations for the protection of our employees and of the environment, we are obliged to certify the harmlessness of all incoming goods.

  • Page 92: Disposal

    Freeze-dryer Delta 2-24 LSCplus 9 Disposal  Disposal  Disposal of the freeze-dryer Martin Christ Gefriertrocknungsanlagen GmbH is a registered manufacturer of electric and electronic devices that are solely intended for commercial use. • Comply with all local rules and regulations. ...

  • Page 93: 10 Technical Data

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 10 Technical data  10 Technical data Manufacturer: Martin Christ Gefriertrocknungsanlagen GmbH An der Unteren Söse 50 37520 Osterode Germany Delta 1-24 LSCplus Delta 2-24 LSCplus Type: Part number: 102300 102301 Performance data...
  • Page 94 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 10 Technical data Connection requirements Delta 1-24 LSCplus Delta 2-24 LSCplus (without vacuum pump and accessories) Electrical connection: 3 x 400 V / 50 Hz 3 x 400 V / 50 Hz...

  • Page 95: Ambient Conditions

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 10 Technical data Special equipment: water Delta 1-24 LSCplus Delta 2-24 LSCplus cooling system Part number: 102302 102303 Cooling water consumption: max. 0.23 m max. 0.37 m Heat carried off via the cooling water: 1.9 kW...

  • Page 96: 11 Appendix

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 11 Appendix  11 Appendix  11.1 Mathematical relations The automatic processes in the “Programmer module” menu (see chapter 6.5.3 - "Option: freeze-drying with the PGMplus programmer module") are based on the following considerations: T/°C...

  • Page 97: Brief Operating Instructions

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 11 Appendix  11.2 Brief operating instructions Functional and operating elements: 1 LSCplus user interface (see chapter 6.5.1 - "User interface") 2 Vacuum pump 3 Oil mist separator Fig. 74: Front of the freeze-dryer 4...
  • Page 98 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 11 Appendix 5 Contact bolt 6 Pipe connection of the vacuum pump (behind the cover plate) 7 Ice condenser 8 Vacuum sensor Fig. 76: Ice condenser chamber 9 Control system on/off (mains power switch) 10...
  • Page 99 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 11 Appendix 11 Aeration valve 12 Media drain valve 13 Fixed castors Fig. 78: Left side of the freeze-dryer 14 Vacuum sensor 15 Mains voltage (Main switch) 16 Electrical connection of the vacuum sensor...
  • Page 100 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 11 Appendix 1 Status line Set process values Button "Set values: view/edit" Actual values of the current process Button "Tools" Button "Schematic system diagram" Button "Process and equipment messages" Button "Operating mode: select/start"...
  • Page 101 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 11 Appendix 11 Start the main drying process either by opening the manual shut-off valve or by waiting for the electromagnetic valve to open. Vacuum is applied to the chamber and the freeze-drying process commences.
  • Page 102 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 11 Appendix 4 Ensure that all of the valves are closed. 5 Let the vacuum pump warm up 20 to 30 minutes before the freeze- drying processes commences. 6 Connect a frozen sample to a valve.

  • Page 103: Ec Declaration Of Conformity In Accordance With The Ec Machinery Directive

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 11 Appendix  11.3 EC declaration of conformity in accordance with the EC Machinery Directive Version 04/2013, Rev. 2.4 of 20/10/2017 • sb 103 / 131 Translation of the original operating manual...
  • Page 104 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 11 Appendix Version 04/2013, Rev. 2.4 of 20/10/2017 • sb 104 / 131 Translation of the original operating manual...

  • Page 105: Declaration Of Conformity - China Rohs 2

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 11 Appendix Declaration of conformity – China RoHS 2 11.4 Version 04/2013, Rev. 2.4 of 20/10/2017 • sb 105 / 131 Translation of the original operating manual...
  • Page 106 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 11 Appendix Version 04/2013, Rev. 2.4 of 20/10/2017 • sb 106 / 131 Translation of the original operating manual...

  • Page 107: Resistance To Stress Cracking And Chemical Influences "Plexiglas

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 11 Appendix 11.5 Resistance to stress cracking and chemical influences "Plexiglas" Version 04/2013, Rev. 2.4 of 20/10/2017 • sb 107 / 131 Translation of the original operating manual...
  • Page 108 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 11 Appendix Version 04/2013, Rev. 2.4 of 20/10/2017 • sb 108 / 131 Translation of the original operating manual...
  • Page 109 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 11 Appendix Version 04/2013, Rev. 2.4 of 20/10/2017 • sb 109 / 131 Translation of the original operating manual...
  • Page 110 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 11 Appendix Version 04/2013, Rev. 2.4 of 20/10/2017 • sb 110 / 131 Translation of the original operating manual...
  • Page 111 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 11 Appendix Version 04/2013, Rev. 2.4 of 20/10/2017 • sb 111 / 131 Translation of the original operating manual...
  • Page 112 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 11 Appendix Version 04/2013, Rev. 2.4 of 20/10/2017 • sb 112 / 131 Translation of the original operating manual...
  • Page 113 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 11 Appendix Version 04/2013, Rev. 2.4 of 20/10/2017 • sb 113 / 131 Translation of the original operating manual...
  • Page 114 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 11 Appendix Version 04/2013, Rev. 2.4 of 20/10/2017 • sb 114 / 131 Translation of the original operating manual...
  • Page 115 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 11 Appendix Version 04/2013, Rev. 2.4 of 20/10/2017 • sb 115 / 131 Translation of the original operating manual...
  • Page 116 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 11 Appendix Version 04/2013, Rev. 2.4 of 20/10/2017 • sb 116 / 131 Translation of the original operating manual...
  • Page 117 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 11 Appendix Version 04/2013, Rev. 2.4 of 20/10/2017 • sb 117 / 131 Translation of the original operating manual...
  • Page 118 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 11 Appendix Version 04/2013, Rev. 2.4 of 20/10/2017 • sb 118 / 131 Translation of the original operating manual...
  • Page 119 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 11 Appendix Version 04/2013, Rev. 2.4 of 20/10/2017 • sb 119 / 131 Translation of the original operating manual...
  • Page 120 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 11 Appendix Version 04/2013, Rev. 2.4 of 20/10/2017 • sb 120 / 131 Translation of the original operating manual...
  • Page 121 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 11 Appendix Version 04/2013, Rev. 2.4 of 20/10/2017 • sb 121 / 131 Translation of the original operating manual...
  • Page 122 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 11 Appendix Version 04/2013, Rev. 2.4 of 20/10/2017 • sb 122 / 131 Translation of the original operating manual...
  • Page 123 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 11 Appendix Version 04/2013, Rev. 2.4 of 20/10/2017 • sb 123 / 131 Translation of the original operating manual...
  • Page 124 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 11 Appendix Version 04/2013, Rev. 2.4 of 20/10/2017 • sb 124 / 131 Translation of the original operating manual...

  • Page 125: 12 Glossary

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus 12 Glossary 12 Glossary Comparative pressure measurement During the sublimation, i.e. when the concentration of water vapour molecules is rather high in the atmosphere, the value that is provided by the gas-type dependent vacuum sensor of the "Pirani" type (e.g. Thyracont VSP 62/63) deviates from the value that is provided by a capacitive vacuum sensor (e.g.
  • Page 126 Wireless Shelf Technology With the Wireless Shelf Technology (WST), Martin Christ Gefrier- trocknungsanlagen GmbH has developed a system for laboratory freeze- dryers that works without cable connections at the electrically heated shelves and other equipment parts.

  • Page 127: 13 Index

    Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus Index 13 Index Configuration of sensors ......57 Connection..........34 Access protection........55 Contact bolt .......... 12, 98 Accessories ........10, 26, 88 Control system on/off ......12, 98 Accident prevention ........24 Control system type ........
  • Page 128 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus Index Dimensions .......... 30, 94 Freezing ............. 18 Direct hazard to the life and health ..... 23 Functional and operating elements .... 11 Disinfectants ..........89 Fuses ............27 Disinfection of the drying chamber and accessories ..........
  • Page 129 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus Index LSCplus control system ......40 On-site transport ........32 Lyo Control measuring system ....78 Operating elements ........11 LyoLogplus data logging software ....78 Operating hours ......... 58 Operating mode: select/start ...... 48 Operating personnel ........
  • Page 130 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus Index Protection class ......... 94 Specialist personnel ........90 Protection of the environment ....25 Standards and regulations ......10 Protective gloves........27 Status line ..........42 steerable castors........12, 98 Step-by-step instructions – drying in a flask Radioactive substances .......
  • Page 131 Freeze-dryer Delta 1-4 LSCplus Freeze-dryer Delta 2-24 LSCplus Index Vacuum sensor (maintenance) ....88 Warranty and liability ........10 Vapour pressure curve above ice ....16 Water cooling system ......... 95 Vapour pressure curve for ice and water ..43 Weight ..........

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