1. Manuals
  2. Brands
  3. Christ Manuals
  4. Dryer
  5. Alpha 1-4 LSCplus
  6. Operating manual

Christ Alpha 1-4 LSCplus Operating Manual

Freeze-dryer
Hide thumbs Also See for Alpha 1-4 LSCplus:
Table of Contents

Advertisement

Quick Links

Translation of the original operating manual
sb
Freeze-dryer
Rev. 2.3 of 03/07/2017
Alpha 1-4 LSCplus;Freeze-dryer;Alpha 2-4 LSCplus
Version 01/2011
Alpha 1-4 LSCplus
Alpha 2-4 LSCplus
Freeze-dryer
Operating Manual
Part no. 102141
Part no. 102142
Please retain for later use!

Advertisement

Table of Contents
loading
Need help?

Need help?

Do you have a question about the Alpha 1-4 LSCplus and is the answer not in the manual?

Questions and answers

Related Manuals for Christ Alpha 1-4 LSCplus

Summary of Contents for Christ Alpha 1-4 LSCplus

  • Page 1 Translation of the original operating manual Freeze-dryer Rev. 2.3 of 03/07/2017 Alpha 1-4 LSCplus;Freeze-dryer;Alpha 2-4 LSCplus Version 01/2011 Alpha 1-4 LSCplus Part no. 102141 Alpha 2-4 LSCplus Part no. 102142 Freeze-dryer Operating Manual Please retain for later use!
  • Page 2 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus Version 01/2011, Rev. 2.3 of 03/07/2017 • sb 2 / 131 Translation of the original operating manual...
  • Page 3 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus In case of inquiries, please state the following numbers: Order number: Serial number: © Copyright by Martin Christ Gefriertrocknungsanlagen GmbH An der Unteren Söse 50 37520 Osterode am Harz Germany Tel.: +49 (0) 5522 / 5007-0...
  • Page 4 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus Version 01/2011, Rev. 2.3 of 03/07/2017 • sb 4 / 131 Translation of the original operating manual...

  • Page 5: Table Of Contents

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus Table of contents General information ......................9 Importance of the operating manual .................. 9 Intended use ........................9 Warranty and liability......................9 Copyright ........................10 Explanation of symbols ....................10 Standards and regulations ....................10 Scope of supply ......................
  • Page 6 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus Table of contents Storage and transport ....................... 28 Dimensions and weight ....................28 Storage conditions ......................28 Notes on transport ......................29 Packaging ........................30 Transport safety device ....................30 Set-up and connection ...................... 31 Installation site ........................
  • Page 7 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus Table of contents Malfunctions and error correction ..................79 General malfunctions ...................... 79 7.1.1 Power failure ......................80 7.1.2 Insufficient vacuum ....................81 7.1.2.1 Small flange connections ................... 81 7.1.2.2 Aeration valve, media drain valve ..............82 7.1.2.3...
  • Page 8 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus Table of contents Version 01/2011, Rev. 2.3 of 03/07/2017 • sb 8 / 131 Translation of the original operating manual...

  • Page 9: General Information

    In addition, the local rules and regulations for the prevention of accidents must be complied with.  Intended use CHRIST freeze-dryers have been solely designed for the freeze-drying of solid or liquid products in ampoules, vials or dishes. They are, therefore, solely intended for these applications. The freeze-dryer is suitable •...

  • Page 10: Copyright

    Freeze-dryer Alpha 2-4 LSCplus 1 General information  Copyright The copyright concerning the operating manual remains with Martin Christ Gefriertrocknungsanlagen GmbH. The operating manual is solely intended for the operator and their personnel. It includes instructions and information that may not be •...

  • Page 11: Layout And Mode Of Operation

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 2 Layout and mode of operation  Layout and mode of operation  Layout of the freeze-dryer  2.1.1 Functional and operating elements 1 Ice condenser chamber with an internal ice condenser 2...
  • Page 12 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 2 Layout and mode of operation 8 Aeration valve 9 Media drain valve Fig. 3: Left side of the freeze-dryer 10 Touchpanel Fig. 4: User interface with touchpanel Version 01/2011, Rev. 2.3 of 03/07/2017 • sb...

  • Page 13: Name Plate

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 2 Layout and mode of operation 11 Vacuum connection 12 Name plate (see chapter 2.1.2 - "Name plate") 13 Heat exchanger of the refrigeration unit 14 Data interface 15 Electrical connection of the vacuum sensor 16...

  • Page 14: Mode Of Operation

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 2 Layout and mode of operation  Mode of operation  2.2.1 General information on freeze-drying What is freeze-drying? Freeze-drying or lyophilisation is a procedure for the gentle drying of high- quality products. The product is dried by  sublimation without passing through the liquid phase.
  • Page 15 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 2 Layout and mode of operation Pressure (mbar) LIQUID Melting SOLID 6.11 mbar Triple point Sublimation 0.37 mbar GASEOUS Temperature (°C) -30°C Fig. 7: Vapour pressure curve above ice From a physical point of view, the freeze-drying process covers three phases (see figure below): (1) Freezing: The product to be dried is frozen under atmospheric pressure.
  • Page 16 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 2 Layout and mode of operation Pressure (mbar) LIQUID 1 bar SOLID Triple point GASEOUS 20°C Temperature (°C) Fig. 8: Freeze-drying phases Please find further information about basic principles, optimum procedures and applications in the brochure "Smart freeze-drying", which can be downloaded at www.martinchrist.de ...

  • Page 17: Freeze-Drying Process

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 2 Layout and mode of operation  2.2.2 Freeze-drying process The main components of a freeze-dryer are: • vacuum drying chamber with a temperature control system for adding thermal energy • vacuum pump for generating a vacuum inside the drying chamber •...

  • Page 18: Main Drying

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 2 Layout and mode of operation Fig. 9: Shell freezing Fig. 10: Cooling bath with spin freezing device Fig. 11: Spin freezing If the product that is to be dried contains solvents or high salt concentrations, it may start to thaw during the drying process, which is indicated by clearly visible foaming.

  • Page 19: Final Drying

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 2 Layout and mode of operation temperature difference between the shelf and the product should be approximately 3 K to 5 K.  2.2.2.4 Final drying Final drying is an option whenever one requires a product with minimal residual moisture.

  • Page 20: Safety

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 3 Safety  Safety  Marking of the unit The following symbols are used for CHRIST freeze-dryers: Dangerous voltage On (Power) Hot surface Off (Power) Name plate (see chapter Caution! Risk of bruising 2.1.2 - "Name plate")

  • Page 21: Explanation Of The Symbols And Notes

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 3 Safety  Explanation of the symbols and notes This operating manual uses the following names and symbols to indicate hazards: This symbol stands for a direct hazard to the life and health of persons.

  • Page 22: Responsibility Of The Operator

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 3 Safety  Responsibility of the operator The operator is obliged to ensure that the persons working with the freeze- dryer • are 18 years old or older, • have been specifically ordered to operate the unit and made aware of...

  • Page 23: Informal Safety Instructions

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 3 Safety  Informal safety instructions This operating manual is a part of the product. • The operating manual must be kept at the location of use of the freeze- dryer. Ensure that it is accessible at all times.

  • Page 24: Electrical Safety

    3 Safety  3.6.1 Electrical safety CHRIST freeze-dryers are units of safety class I. Please comply with the following points in order to preserve the safety features: • Ensure that the local mains voltage matches the nominal voltage that is stated on the name plate.

  • Page 25: Fire Prevention

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 3 Safety  3.6.3 Fire prevention Fuses protect certain electrical circuits within the freeze-dryer against over- current conditions. • Always use fuses of the same type and rating. • Do not dry explosive or inflammable substances.

  • Page 26: Safety Devices

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 3 Safety  Safety devices  3.7.1 System check An internal system check system monitors the data transfer and sensor signals with regard to plausibility. Errors are detected by continuous self- monitoring of the system. Error messages are displayed in the main window under "Process &...

  • Page 27: Remaining Hazards

    3 Safety  Remaining hazards All CHRIST freeze-dryers were built state-of-the-art and according to the accepted safety rules. Danger to life and limb of the operator, or of third parties, or impairments of the units or other material assets, however, cannot be completely excluded when the units are being used.

  • Page 28: Storage And Transport

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 4 Storage and transport  Storage and transport  Dimensions and weight Values for the freeze-dryer without a vacuum pump: Alpha 1-4 LSCplus Alpha 2-4 LSCplus Height: 415 mm 415 mm Width:...

  • Page 29: Notes On Transport

    Fig. 12: Lifting the freeze-dryer The freeze-dryer Alpha 1-4 LSCplus weighs approx. 48 kg! The freeze-dryer Alpha 2-4 LSCplus weighs approx. 60 kg! CAUTION • When setting the unit down, ensure that the feet are upright (see figures below).

  • Page 30: Packaging

    Lift the freeze-dryer upwards and out of the crate/cardboard box. When lifting the unit, always reach under the freeze-dryer from the side. The freeze-dryer Alpha 1-4 LSCplus weighs approx. 48 kg! The freeze-dryer Alpha 2-4 LSCplus weighs approx. 60 kg! CAUTION •...

  • Page 31: Set-Up And Connection

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 5 Set-up and connection  Set-up and connection  Installation site Operate the freeze-dryer only in closed and dry rooms. Refrigeration problems of the freeze-dryer are often caused by insufficient conditions at the location of use. This is why compliance with the following...

  • Page 32: Power Supply

    DANGER CHRIST freeze-dryers are units of safety class I. Alpha 1-4 LSCplus and Alpha 2-4 LSCplus units have a three-wire power cord with a fixed cable(see chapter 10 - "Technical data"). An equipotential bonding screw is located on the back below the mains power input (see chapter 2.1.1 - "Functional and operating elements").

  • Page 33: Vacuum Sensor

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 5 Set-up and connection  Vacuum sensor Please refer to the separate operating manual of the vacuum sensor! NOTE In order to protect the vacuum sensor against transport damage, it comes supplied in its original packaging. Prior to commissioning the freeze-dryer, the sensor must be installed.
  • Page 34 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 5 Set-up and connection Thyracont VCP63 (Pirani) Pfeiffer CMR 363 (capacitive) Fig. 15: Vacuum sensors of different manufacturers The vacuum sensor comes supplied in a calibrated state. NOTE After the freeze-dryer has been switched on, the vacuum sensor needs several minutes until it is ready for operation.

  • Page 35: Vacuum Pump

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 5 Set-up and connection 5.4.6 Vakuumpumpe  Vacuum pump It is absolutely essential to refer to the separate instruction manual of the vacuum pump and exhaust filter (if applicable)! NOTE The vacuum pump must be connected to the vacuum connection of the unit and to the electrical socket at the back of the unit, which is marked accordingly (see chapter 2.1.1 - "Functional and operating elements").

  • Page 36: Pressure Control Valve

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 5 Set-up and connection  Pressure control valve The pressure control valve is integrated in the suction pipe between the vacuum pump and ice condenser chamber. During certain, specified process phases, it interrupts the volume flow to the vacuum pump (see chapter 2.2.1 - "General information on freeze-drying").

  • Page 37: Rubber Valves

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 5 Set-up and connection  Rubber valves The rubber valves (part no. 121860) enable the connection of round-bottom flasks, wide-neck filter bottles, or distributors for ampoules to a manifold or drying chamber. Depending on the connector of the components, the blue plug can be removed.

  • Page 38: Operation

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation Operation Initial start-up Before the initial start-up, please ensure that your freeze-dryer is properly set up and installed (see chapter 5 - "Set-up and connection") WARNING  Installation of accessories The accessories must be completed in accordance with the drying method that is applied as well as in accordance with the scope of supply.

  • Page 39: Lscplus Control System

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation LSCplus control system The control system LSCplus (Lyo Screen Control plus) was specifically developed for the control of freeze-drying processes. The clear user interface enables the intuitive operation of the unit.

  • Page 40: Main Window "Manual

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation The user interface is divided into four main windows that can be called up by touching the corresponding buttons: Manual This window is also the standard user interface. It is used to control the freeze-drying process manually.
  • Page 41 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation Status line (1) This line shows the operating status of the freeze-dryer as well as the active phase. The status line also shows the current date and time. The clock is battery- buffered and must be reset after a failure (chapter 6.5.1.3 - "Main window...
  • Page 42 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation Actual values of the current process (4) This area shows the current process data. The fields can be configured as desired: • Select the button of the field that is to be adapted. A dialog box opens: Fig.
  • Page 43 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation Option: USB process recording (see chapter 6.6 - "Optional extensions") • Select the "Process recording" function in the dialog box "Tools". • Select the input fields ("Batch data"). A keyboard for the data input will be displayed.
  • Page 44 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation Fig. 26: Dialog box “Pressure increase test” • The "Test stop" button stops the pressure increase test. Dialog box "Schematic system diagram" (6) Pressing the button "Schematic system diagram" displays a schematic diagram of the system on the left-hand side of the screen, including all the components.
  • Page 45 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation Malfunctions are divided into three categories: • Red: error messages • Orange: process messages • Yellow: general messages The representation of the message provides information on its current status. A double frame around a message means that the error has not been eliminated yet.
  • Page 46 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation Use the arrow keys to call up the individual windows. The error message text is always followed by an error code. Always indicate the error code in the event of enquiries or service requests! NOTE 4...
  • Page 47 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation Standard unit test Apart from the process phases of the freeze-drying process ("Freezing", "Warm-up", "Main drying", and "Final drying") and the operating mode "Defrosting", the button "Unit Test" is also available. This button opens a selection of a test with fixed parameters.
  • Page 48 Final vacuum after 2 h xxx mbar Evaluation: Please contact the Martin Christ Gefriertrocknungsanlagen GmbH for an assessment of the results.. Button "Stop" (9) Pressing this button stops the current process. The system switches to the standby status.

  • Page 49: Main Window "Program

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation 6.5.1.2 Main window "Program" In the main window "Program", pre-programmed freeze-drying processes can be loaded and edited and new programs can be created with the PGMplus programmer module. For this function, the PGMplus programmer module must be available.

  • Page 50: Main Window "Options

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation 6.5.1.3 Main window "Options " The main window "Options" is used to perform fundamental basic settings of the control system in order to adapt it perfectly to the respective area of application of the freeze-dryer.
  • Page 51 • Double chamber method LyoCube (outside): drying outside the ice condenser chamber, but with the CHRIST LyoCube (a rectangular drying chamber that can be loaded from the front) Fig. 37: Dialog box "Freeze-drying processes" Version 01/2011, Rev. 2.3 of 03/07/2017 • sb...
  • Page 52 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation Administration “Administration” options: "Date/Time" "Network" "System properties" "Access protection" "Device options" "Configuration of sensors" Abb. 38: Dialogfenster "Optionen" / Verwaltung Date/Time (1) The LSC control system is equipped with an integrated, battery-buffered plus clock.
  • Page 53 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation Fig. 40: Dialog box "Network" System properties (3) This dialog box is used to change various system settings. Fig. 41: Dialog box "System properties" Beeper: The beeper sounds in the event of a malfunction, for example.
  • Page 54 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation Access protection (4) In this dialog box, the access rights can be managed on several levels and they can be protected with a password. In the factory setting with an activated access protection, data can be viewed but not edited.
  • Page 55 • Press the button "Add option". An input window opens. • Enter the six-digit Christ activation code that was supplied for this option. Note that the keys are case sensitive. Options can be removed in the same way. The modifications will not become effective until after a restart of the unit.
  • Page 56 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation Configuration of sensors (6) The sensor configurations depend on the equipment version of the unit. If the configuration is incorrect, the correct operation of the unit cannot be guaranteed. CAUTION This dialog box is used to configure the existing vacuum and pressure sensors.
  • Page 57 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation Service “Service” options: 1 "Operating hours" 2 "Failure memory" 3 "Wireless shelf technology" 4 "Vacuum pump oil change" 5 "Maintenance" 6 "Sensor adjustment" Fig. 47: Dialog box "Service" (varies depending on the type of system)
  • Page 58 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation Failure memory (2) The failure memory stores the most recent messages of the process and equipment information system. These messages can be viewed in this dialog box. The failure memory includes the last 32 messages. If this number is exceeded, the oldest message will be overwritten.
  • Page 59 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation Fig. 50: Wireless shelf technology – assignment of shelf addresses • In order to assign an address, open the dialog box "Wireless Shelf Technology". • Ensure that only the WST module to which an address is to be assigned is connected.
  • Page 60 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation Maintenance (5) The maintenance interval of the unit is fixed at 3,000 operating hours or at least one maintenance per year. When the end of a maintenance interval is reached, a corresponding message will be displayed.
  • Page 61 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation Sensor adjustment (6) Misadjusted sensors will lead to incorrect measurement values, which in turn will have a negative effect on the process control. CAUTION In this dialog box, the sensors are adjusted in terms of a predefined reference value.

  • Page 62: Main Window

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation 6.5.1.4 Main window "?" This main window includes the most important information concerning your freeze-dryer: Freeze-dryer type Control system type Serial number Manufacturer contact data Details concerning the software version Fig.

  • Page 63: Entering Set Values In The Manual Mode

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation If in one section the value "∞" (infinite) is selected for a process phase, the next phase must be started manually via the button "Operating mode: select/start". NOTE In the manual mode, the set values of the active phase can be changed during the process run.
  • Page 64 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation Viewing or editing the set values: • Press the button "Set values: view/edit" (see chapter 6.5.1.1 - "Main window "Manual""). The following dialog box will be displayed: "Aeration" button 2...

  • Page 65: Option: Freeze-Drying With The Pgmplus Programmer Module

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation Numerical values can be edited with the aid of a numerical keypad: Set value display Button for changing the sign (e.g. when entering temperature values) "" (infinite) Button for editing the...
  • Page 66 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation Fig. 58: Representation of a freeze-drying program Program sections When the programmer module executes a freeze-drying process, it executes the various sections that were created one after the other until the last section is completed.
  • Page 67 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation Conditions for switching to the next section For all of the program sections to be executed automatically, certain switching conditions must be fulfilled at the end of each section. If these conditions are not fulfilled, e.g.
  • Page 68 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation Vacuum pump warm-up Apart from the execution of the various sections, the PGMplus programmer module also controls other tasks that need to be performed during the process run, e.g. the automatic activation of the vacuum pump.

  • Page 69: Creating A Program

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation 6.5.3.1 Creating a program To create a new program: • Press the button "New program" in the main window "Program". The dialog box that is displayed offers various different program templates.
  • Page 70 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation “Program” buttons: "Program" "Program name" "Show diagram " "Insert section " "Delete section " Button for calling up more functions and set values "Save" Fig. 62: Editing a blank program template •...
  • Page 71 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation Button ">>more" The button ">>more" can be used to enter more functions and set values in a program-related manner. Fig. 63: Selection of program-related functions and set values Vacuum pump warm-up See chapter 6.6 - "Optional extensions"...
  • Page 72 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation Otherwise, a process message will be issued, the current section will be extended, and further pressure increase tests will be executed periodically until the condition is fulfilled. If the actual value exceeds the set value before the preselected time has elapsed, the test will be aborted in order to prevent the product from thawing.
  • Page 73 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation Option: Comparative pressure measurement (see chapter 6.6 - "Optional extensions") The indication of the measurement value "dp Comp" can be configured in chapter 6.5.1.1 - "Main window "Manual"" under "Actual values of the current process"...

  • Page 74: Editing A Program

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation Program templates (2) The PGMplus programmer module offers 14 different program templates that include recipes for all kinds of freeze-drying applications. They are suggestions for orientation purposes and must be adapted to the specific area of application of the freeze-dryer.

  • Page 75: Copying A Program

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation 6.5.3.3 Copying a program If a new program is to be created based on an already existing program, the already existing program can be copied. A free program storage location must be available for this purpose.

  • Page 76: Deleting A Program

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 6 Operation Fig. 68: The freeze-drying process can be started with the aid of the button “Program start”. • During the freeze-drying process, the description of the active program can also be called up from the main window "Program" and via the button "Info".

  • Page 77: Optional Extensions

    Since absolutely tight components simply do not exist, a leak rate is determined. The parameters for the leakage test have been developed by Martin Christ Gefrier- trocknungsanlagen specifically for freeze-dryers. In a first step, these parameters (vacuum, ice condenser temperature) must be reached.

  • Page 78: Switching The Freeze-Dryer Off

    LPCplus SCADA system The Christ LPCplus system consists of the Supervisory Control And Data Acquision (SCADA) software program by Martin Christ Gefriertrocknungs- anlagen GmbH and a dedicated PC. The system is connected to the...

  • Page 79: Malfunctions And Error Correction

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 7 Malfunctions and error correction  Malfunctions and error correction Malfunctions are displayed in the dialog box "Process & equipment messages" (see chapter 7.2 - "Process and error messages"). An acoustic signal sounds when an error message is generated.

  • Page 80: Power Failure

    • The thermal circuit breaker has Ensure sufficient air circulation tripped. (see chapter 7.1.3 - "Insufficient ice condenser temperature") If it is impossible to eliminate the errors, contact the Christ service department! NOTE  7.1.1 Power failure The control system continues with the process after a power failure. The preselected conditions remain saved even during a process run.

  • Page 81: Insufficient Vacuum

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 7 Malfunctions and error correction  7.1.2 Insufficient vacuum The vacuum checks must be carried out when the ice condenser is frozen. NOTE  7.1.2.1 Small flange connections Leakages are often due to improper small flange connections between the various components and hose connections or to leakages in the valves.

  • Page 82: Aeration Valve, Media Drain Valve

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 7 Malfunctions and error correction  7.1.2.2 Aeration valve, media drain valve A malfunction of the aeration valve or the media drain valve may have several causes. One potential source are contaminants such as product residues within the valve.

  • Page 83: Insufficient Ice Condenser Temperature

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 7 Malfunctions and error correction  7.1.3 Insufficient ice condenser temperature Ensure sufficient ventilation. Do not place any paper, cloth, or similar material behind or under the unit, since otherwise the air circulation will be impaired.

  • Page 84: Service Contact

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 7 Malfunctions and error correction  Service contact In the event of queries, malfunctions, or spare part enquiries: From Germany: Contact Martin Christ Gefriertrocknungsanlagen GmbH An der Unteren Söse 50 37520 Osterode (Germany) Tel.

  • Page 85: Maintenance And Service

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 8 Maintenance and service  Maintenance and service The freeze-dryer and the accessories are subject to high mechanical stress. Thorough maintenance performed by the user extends the service life and prevents premature failure.

  • Page 86: Ice Condenser Chamber

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 8 Maintenance and service Cleaning of the freeze-dryer • Switch the freeze-dryer off by actuating the mains power switch and disconnect the power cord from the wall outlet before cleaning. • If the freeze-dryer has been contaminated with toxic, radioactive, or...

  • Page 87: Heat Exchanger (Only For Air-Cooled Freeze-Dryers)

    This is why the selected set-up location should be as clean as possible. • Check the heat exchanger at least once per month for soiling and clean it if necessary. • Please contact the Christ service department if you have any queries (see chapter 7.3 - "Service contact").  8.1.5 Vacuum pump...

  • Page 88: Exhaust Filter (Oil Mist Separator)

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 8 Maintenance and service  8.1.6 Exhaust filter (oil mist separator) Please refer to the separate operating manual of the vacuum pump and the exhaust filter! NOTE The oil mist that is emitted by the vacuum pump in quantities that depend on the working pressure must be led to the outside or to an exhaust hood or similar.

  • Page 89: Disinfection Of The Drying Chamber And Accessories

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 8 Maintenance and service • Check the material regularly (at least once a month) for – cracks – visible damage of the surface – pressure marks – signs of corrosion – other changes.

  • Page 90: Service

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 8 Maintenance and service Service In the event of service work that requires the removal of the panels, there is a risk of electric shock or mechanical injury. Only qualified specialist personnel is authorised to perform this service work.
  • Page 91 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 8 Maintenance and service 1. Declaration of decontamination As a certified company and due to the legal regulations for the protection of our employees and of the environment, we are obliged to certify the harmlessness of all incoming goods.

  • Page 92: Disposal

    Freeze-dryer Alpha 2-4 LSCplus 9 Disposal  Disposal  Disposal of the freeze-dryer Martin Christ Gefriertrocknungsanlagen GmbH is a registered manufacturer of electric and electronic devices that are solely intended for commercial use. • Comply with all local rules and regulations. ...

  • Page 93: 10 Technical Data

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 10 Technical data  10 Technical data Manufacturer: Martin Christ Gefriertrocknungsanlagen GmbH An der Unteren Söse 50 37520 Osterode Germany Alpha 1-4 LSCplus Alpha 2-4 LSCplus Type: Part number: 102141 102142 Performance data...
  • Page 94 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 10 Technical data Connection requirements Alpha 1-4 LSCplus Alpha 2-4 LSCplus (without vacuum pump and accessories) Electrical connection: 1 x 230V / 50-60 Hz 1 x 230V / 50-60 Hz Protection class:...

  • Page 95: Ambient Conditions

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 10 Technical data Special equipment: water Alpha 1-4 LSCplus Alpha 2-4 LSCplus cooling system Part number: 102143 102144 Cooling water consumption: max. 0.16 m max. 0.20 m Heat carried off via the cooling water: 1.1 kW...

  • Page 96: 11 Appendix

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 11 Appendix  11 Appendix  11.1 Mathematical relations The automatic processes in the “Programmer module” menu (see chapter 6.5.3 - "Option: freeze-drying with the PGMplus programmer module") are based on the following considerations: T/°C...

  • Page 97: Brief Operating Instructions

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 11 Appendix  11.2 Brief operating instructions Functional and operating elements 1 Ice condenser chamber with an internal ice condenser 2 User interface 3 Mains power switch Fig. 75: Total view of the freeze-dryer 4...
  • Page 98 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 11 Appendix 8 Aeration valve 9 Media drain valve Fig. 77: Left side of the freeze-dryer 10 Touchpanel Fig. 78: User interface with touchpanel Version 01/2011, Rev. 2.3 of 03/07/2017 • sb...
  • Page 99 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 11 Appendix 11 Vacuum connection 12 Name plate 13 Heat exchanger of the refrigeration unit 14 Data interface 15 Electrical connection of the vacuum sensor 16 Connection of the vacuum sensor 17 Option: USB port 18...
  • Page 100 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 11 Appendix Step-by-step instructions – shelf drying 1 Freeze the sample separately, e.g. in a deep-freeze. Ensure that the layer thickness of 1 to 2 cm is not exceeded, since otherwise the drying time needs to be extended.
  • Page 101 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 11 Appendix 16 Switch the unit on again and start the defrosting process (button "Operating mode: select/start" – "Defrosting”). Ensure that no water gets into the pipe connection of the vacuum pump or vacuum sensor.
  • Page 102 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 11 Appendix 8 The end of the process is reached when the ice condenser is no longer loaded and when it again reaches a final temperature of approximately - 50°C to -54°C. The pressure decreases as a function of the ice condenser temperature.

  • Page 103: Ec Declaration Of Conformity In Accordance With The Ec Machinery Directive

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 11 Appendix  11.3 EC declaration of conformity in accordance with the EC Machinery Directive Version 01/2011, Rev. 2.3 of 03/07/2017 • sb 103 / 131 Translation of the original operating manual...
  • Page 104 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 11 Appendix Version 01/2011, Rev. 2.3 of 03/07/2017 • sb 104 / 131 Translation of the original operating manual...

  • Page 105: Declaration Of Conformity - China Rohs 2

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 11 Appendix Declaration of conformity – China RoHS 2 11.4 Version 01/2011, Rev. 2.3 of 03/07/2017 • sb 105 / 131 Translation of the original operating manual...
  • Page 106 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 11 Appendix Version 01/2011, Rev. 2.3 of 03/07/2017 • sb 106 / 131 Translation of the original operating manual...

  • Page 107: Resistance To Stress Cracking And Chemical Influences "Plexiglas

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 11 Appendix 11.5 Resistance to stress cracking and chemical influences "Plexiglas" Version 01/2011, Rev. 2.3 of 03/07/2017 • sb 107 / 131 Translation of the original operating manual...
  • Page 108 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 11 Appendix Version 01/2011, Rev. 2.3 of 03/07/2017 • sb 108 / 131 Translation of the original operating manual...
  • Page 109 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 11 Appendix Version 01/2011, Rev. 2.3 of 03/07/2017 • sb 109 / 131 Translation of the original operating manual...
  • Page 110 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 11 Appendix Version 01/2011, Rev. 2.3 of 03/07/2017 • sb 110 / 131 Translation of the original operating manual...
  • Page 111 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 11 Appendix Version 01/2011, Rev. 2.3 of 03/07/2017 • sb 111 / 131 Translation of the original operating manual...
  • Page 112 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 11 Appendix Version 01/2011, Rev. 2.3 of 03/07/2017 • sb 112 / 131 Translation of the original operating manual...
  • Page 113 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 11 Appendix Version 01/2011, Rev. 2.3 of 03/07/2017 • sb 113 / 131 Translation of the original operating manual...
  • Page 114 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 11 Appendix Version 01/2011, Rev. 2.3 of 03/07/2017 • sb 114 / 131 Translation of the original operating manual...
  • Page 115 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 11 Appendix Version 01/2011, Rev. 2.3 of 03/07/2017 • sb 115 / 131 Translation of the original operating manual...
  • Page 116 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 11 Appendix Version 01/2011, Rev. 2.3 of 03/07/2017 • sb 116 / 131 Translation of the original operating manual...
  • Page 117 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 11 Appendix Version 01/2011, Rev. 2.3 of 03/07/2017 • sb 117 / 131 Translation of the original operating manual...
  • Page 118 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 11 Appendix Version 01/2011, Rev. 2.3 of 03/07/2017 • sb 118 / 131 Translation of the original operating manual...
  • Page 119 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 11 Appendix Version 01/2011, Rev. 2.3 of 03/07/2017 • sb 119 / 131 Translation of the original operating manual...
  • Page 120 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 11 Appendix Version 01/2011, Rev. 2.3 of 03/07/2017 • sb 120 / 131 Translation of the original operating manual...
  • Page 121 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 11 Appendix Version 01/2011, Rev. 2.3 of 03/07/2017 • sb 121 / 131 Translation of the original operating manual...
  • Page 122 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 11 Appendix Version 01/2011, Rev. 2.3 of 03/07/2017 • sb 122 / 131 Translation of the original operating manual...
  • Page 123 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 11 Appendix Version 01/2011, Rev. 2.3 of 03/07/2017 • sb 123 / 131 Translation of the original operating manual...
  • Page 124 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 11 Appendix Version 01/2011, Rev. 2.3 of 03/07/2017 • sb 124 / 131 Translation of the original operating manual...

  • Page 125: 12 Glossary

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus 12 Glossary 12 Glossary Comparative pressure measurement During the sublimation, i.e. when the concentration of water vapour molecules is rather high in the atmosphere, the value that is provided by the gas-type dependent vacuum sensor of the "Pirani" type (e.g. Thyracont VSP 62/63) deviates from the value that is provided by a capacitive vacuum sensor (e.g.
  • Page 126 Wireless Shelf Technology With the Wireless Shelf Technology (WST), Martin Christ Gefrier- trocknungsanlagen GmbH has developed a system for laboratory freeze- dryers that works without cable connections at the electrically heated shelves and other equipment parts.

  • Page 127: 13 Index

    Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus Index 13 Index Connection..........32 Connection of the vacuum sensor ..13, 99 Access protection........54 Connection requirements ......94 Accessories ........10, 24, 88 Control system type ........62 Accident prevention ........22 Cooling system ..........
  • Page 128 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus Index Dialog box "Schematic system diagram ..44 Freeze-drying phases ........ 16 Dialog box "Tools" ........42 Freeze-drying process ......17, 51 Dimensions ..........94 Freeze-drying with the PGMplus programmer module ........... 65 Dimensions and weight ......
  • Page 129 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus Index Leakage in the media drain valve ....79 Nominal voltage ........13, 24 Leakage test ........63, 77 Notes on safety and hazards ....... 9 Loading a program ........75 Notes on transport ........29 LPCplus SCADA system ......
  • Page 130 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus Index Procedures in the event of hazards and Single-chamber method (inside) ....51 accidents ..........26 Small flange connections ......81 Process and equipment messages .... 44 Solvents............. 85 Process and error messages ..... 83 Special equipment:water cooling system ...
  • Page 131 Freeze-dryer Alpha 1-4 LSCplus Freeze-dryer Alpha 2-4 LSCplus Index Vacuum pump is not activated ....80 Vacuum pump oil change ......59 Warm-up of the vacuum pump ....68 Vacuum pump warm-up ......68 Warranty and liability ........9 Vacuum pump, cleaning and care ....87 Water cooling system .........

This manual is also suitable for:

102141102142Alpha 2-4 lscplus

Table of Contents

Save PDF