Christ ALPHA 1-4 LDplus Operating Manual
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Christ ALPHA 1-4 LDplus Operating Manual

Freeze-dryer
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Operating Manual Freeze-dryer
ALPHA 1-4 LDplus
ALPHA 2-4 LDplus
Version 11.2006 –Translation of the original operating manual
Part. No. 101541
Part. No. 101542
Revision 1.9 of 19/12/2013

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Summary of Contents for Christ ALPHA 1-4 LDplus

  • Page 1 Operating Manual Freeze-dryer ALPHA 1-4 LDplus Part. No. 101541 ALPHA 2-4 LDplus Part. No. 101542 Version 11.2006 –Translation of the original operating manual Revision 1.9 of 19/12/2013...
  • Page 2 Донау Лаб. Москва/ «Donau Lab. Moscow» - дилер Martin Christ GmbH в России Тел. +7 (495)-255-33-89 Адрес: 119034, Москва, Турчанинов пер, д.6, стр.2 www.donaulab.ru...
  • Page 3 [Service Area] Phone +49 (0) 55 22 / 50 07-84 25 Fax +49 (0) 55 22 / 50 07-94 25 E-mail: service@martinchrist.de Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...

  • Page 5: Table Of Contents

    4.8.2. Connection of vacuum sensor vacuum Pump, and pressure control valve.................. 33 4.8.3. Diagram of the accessories ............36 4.8.4. Rubber valves ................39 4.8.5. Switching-on ................. 40 Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus Contents...
  • Page 6 7.1.7.4. Maintenance of the Aeration Valve and the Drain Valve..59 7.1.8. Disinfection of Drying Chamber, Lid and Accessories ....60 7.1.9. Checks by Operator ..............60 7.2. Service ...................... 61 7.3. Return of defective parts ................62 Contents Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...
  • Page 7 Process Control System LPC-32, Software with PC hardware ....63 8.3. LyoLog LL-1 (Documentation Software) ............. 63 8.4. LDplus Simulation Tool (Training Software) ..........63 8.5. Electrical lifting device ................63 Enclosures Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus Contents...

  • Page 8: General Information

    Lyophilisation is also the best method when drying inorganic products – e.g. nanoscale dispersions – the particle surfaces of which should remain unchanged. General Information Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...

  • Page 9: Applications

    Normally done separately in a deep-freeze Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus General Information...

  • Page 10: Technical Specification

    415mm height: 415mm depth: 555mm depth: 555mm (incl. vacuum-flange (incl. vacuum-flange connection) connection) Weight: approx.42kg approx.55kg Noise emissions according 54 dB(A) 54 dB(A) to DIN 45635: General Information Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...

  • Page 11: Note! Technical Documentation

    Please ask for the documents in case of need via Internet at www.martinchrist.de by using the form "service request". Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus General Information...

  • Page 12: Scope Of Delivery

    Special caution is necessary when using azides because a dangerous explosive develops in combination with copper or non- ferrous metals! It is absolutely essential to consult our service department! General Information Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...

  • Page 13: Advice! Cleaning And Maintenance Of The Unit

    WARNING! When transporting or putting down the unit do not hold the plastic control panel. Please note: When putting the unit down on a surface there is a danger of squeezing hands or fingers. WRONG CORRECT Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus General Information...

  • Page 14: Prohibited Freeze-Drying Processes

    11. Do not freeze-dry explosive or highly inflammable substances. 12. Infectious, toxic, pathogenic and radioactive substances must only be dried in suitable vessels. General Information Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...

  • Page 15: General Information On Freeze-Drying

    -105°C (depending on type of unit) to remove the water vapour from the chamber (= vapour pump) Heatable (controlled) shelves are only possible with an LSC control system. Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus General Information on Freeze-drying...
  • Page 16 1mbar = 100Pa = 0.01mbar Temperature units: T = thermodynamic temperature K (Kelvin) t = temperature in degree Celsius °C = temperature in degree Fahrenheit °F General Information on Freeze-drying Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...
  • Page 17 1,980 0,280 0,025 0,0017 1,810 0,250 0,024 0,0014 1,650 0,220 0,021 0,0012 1,510 0,200 0,018 0,0010 1,370 0,180 0,016 1,250 0,160 0,014 1,140 0,140 0,012 Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus General Information on Freeze-drying...

  • Page 18: Preparation

    In this case, especially when freeze-drying small quantities, it is advisable to pre-cool the shelves in order to avoid partial thawing during the evacuation. General Information on Freeze-drying Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...

  • Page 19: Main Drying

    Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus General Information on Freeze-drying...
  • Page 20 (eutectic point). General Information on Freeze-drying Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...
  • Page 21 This applies especially to inhomogeneous products and to great layer thicknesses. During this drying phase it is important to regulate the heat supply and control temperature and pressure precisely. Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus General Information on Freeze-drying...

  • Page 22: Final Drying

    To do this, a hose is put onto the nozzle. The condensate and the defrosting water are collected in a vessel. General Information on Freeze-drying Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...
  • Page 23 Pipe connection for vacuum pump (behind baffle plate) Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus General Information on Freeze-drying...

  • Page 25: Description Of The Freeze-Drying Processes

    To do so, the main drying process has to be activated in the control system so that the pressure control valve opens and the main drying process starts (see chapter 5.6). Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus Description of the Freeze-drying Processes...

  • Page 26: Separate Freezing And Drying Outside The Ice Condenser Chamber (Process B) With Sealing Device

    (according to the height of the bottles with inserted rubber stoppers). The appropriate spacers are available upon request. Description of the Freeze-drying Processes Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...

  • Page 27: Separate Freezing And Drying Of Liquids In Flasks (Process B)

    It is also possible to connect a distributor for 15 ampoules to every rubber valve. Using a distributor a maximum of 15 ampoules can be simultaneously frozen in the cooling bath and connected to the manifold. Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus Description of the Freeze-drying Processes...

  • Page 28: Separate Freezing And Drying Of Liquids In Ampoules (Process B)

    The remaining glass from the ampoule is removed and the hose is closed with a blind plug. In this way one ampoule after the other can be sealed or new ampoules can be connected. Description of the Freeze-drying Processes Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...

  • Page 29: Installation And Commissioning Of The Unit

    CHRIST freeze-dryers are units of safety class I. The units of the type ALPHA 1-4 LDplus / ALPHA 2-4 LDplus are equipped with a three-wire power cord with a IEC C13 connector (see also chapter 1.3 "Technical specification").

  • Page 30: Checking The Earth Connection

    The drain valve is also used to vent the unit when a freeze-drying process has been completed. Installation and Commissioning of the Unit Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...

  • Page 31: Vacuum Pump Exhaust

    4.8. Initial Start-up CAUTION! Ensure that the freeze-dryer is correctly mounted and installed before initial start-up (see point 4.1 Site of Installation and following points). Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus Installation and Commissioning of the Unit...

  • Page 32: Functional Components And Control Elements

    Mains fuse protection Mains cable Potential equalising screw for protective ground wire check and central earth connection Heat exchanger of Name plate the refrigeration unit Installation and Commissioning of the Unit Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...

  • Page 33: Connection Of Vacuum Sensor Vacuum Pump, And Pressure Control Valve

    3 Ice condenser 11 Pressure control valve 4 Glass lid 12 Aeration valve 5 Drying chamber 13 Rubber valve 6 Heatable shelf 14 Thermal insulation Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus Installation and Commissioning of the Unit...
  • Page 34 Ensure that the centring ring neither slips out of place nor gets jammed. Small flange and centring ring Small flange with centring ring and small flange Attaching the clamping ring Tightened clamping ring Installation and Commissioning of the Unit Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...
  • Page 35 In case the drying chamber is equipped with rubber valves they have to be closed. Further accessories (e.g. shelves, connections for round bottom flasks) are added accordingly. Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus Installation and Commissioning of the Unit...

  • Page 36: Diagram Of The Accessories

    Ø300 Drying vessel e.g. injection bottle Drip tray Base plate ALPHA 1-4 LD plus ALPHA 2-4 LD plus Installation and Commissioning of the Unit Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...
  • Page 37 Lid Ø300 Manifold, various types, for a max. of 24 rubber valves ALPHA 1-4 LD plus ALPHA 2-4 LD plus Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus Installation and Commissioning of the Unit...
  • Page 38 Drying vessel e.g. e.g. ampoule injection bottle Max. 5 shelves Product dish Ø375 (unheated) Connection flange ALPHA 1-4 LD plus ALPHA 2-4 LD plus Installation and Commissioning of the Unit Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...

  • Page 39: Rubber Valves

    In position (2), the aeration connector is closed and the vessel connector is open. The connected accessory is connected to the freeze-dryer. Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus Installation and Commissioning of the Unit...

  • Page 40: Switching-On

    In the end, the program inquires as to whether the user wants the tutorial to be displayed again when the unit is switched on the next time. Installation and Commissioning of the Unit Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...

  • Page 41: Ldplus Control System

    Inside the menu, the “up” key and the “down” key are used to shift the focus. When parameters are entered, they are used to change the value. Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus LDplus Control System...

  • Page 42: Visual Components Of The Ldplus Control System

    The freeze-dryer is in the standby mode. All aggregates are switched off. The freeze-dryer is in the run mode. The timer is deactivated. The freeze-dryer is in the run mode. The timer is activated. LDplus Control System Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...

  • Page 43: Active Phase

    In the screenshot, the left-hand softkey has the function Mode and the right-hand softkey has the function Menu Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus LDplus Control System...

  • Page 44: Values Window

    (see the chapter "General Information on Freeze- drying"). This measuring channel can only be selected if a vacuum sensor is installed. LDplus Control System Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...

  • Page 45: Mode

    If the last phase is active, the system inquires as to whether the process should be continued or stopped (standby). To deactivate the timer, select an infinite set value ( ). Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus LDplus Control System...

  • Page 46: Main Menu

    “up” “down” keys. Press OK to confirm the set value or Cancel to reject it. The editing mode is quit. LDplus Control System Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...

  • Page 47: Set Values For Freezing

    A detailed description of the special functions can be found in the chapter “LDplus Special Functions”. 5.7.3. Process and equipment information system Further information can be found in the chapter “Process and equipment information system”. Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus LDplus Control System...

  • Page 48: Options

    A brief sound signal can be heard whenever a key is pressed. High temperature resolution Temperatures are displayed in the values window with a resolution °C, normally with a resolution of 1°C. LDplus Control System Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...

  • Page 49: Service Menu

    This area is password-protected and not available to the user. 5.7.5. Tutorial Starts the tutorial of the LDplus control system (available only in German, English or French). Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus LDplus Control System...

  • Page 50: Process And Equipment Information System

    In order to quit the process & equipment information window, you have to acknowledge all pieces of information so that the softkey can be displayed. Back LDplus Control System Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...

  • Page 51: Ldplus Special Functions

    It is not possible to move the drying chamber during main drying or final drying. Use the “up” and “down” keys to move the drying chamber. Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus LDplus Control System...

  • Page 53: Error Correction

    If the leakage cannot be eliminated in this way, the drain valve must be cleaned or replaced. Check the sealing of the lid for dirt or damages. If necessary, the sealing must be cleaned or replaced. Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus Error Correction...

  • Page 54: Unit Does Not Function

    Is the mains switch plugged in? Check the on site fuses. Check the automatic circuit breaker 1F1 on the back of the unit. Error Correction Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...

  • Page 55: Insufficient Ice Condenser Temperature

    Lid or drying chamber not mounted correctly. Missing ground-in stopper in the lid or in the drying chamber. Defective vacuum pump. Check whether the mains switch of the vacuum pump is switched on. Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus Error Correction...
  • Page 56 IO communication error (0x20) Error in the IO module LDplus EA Please contact our service department. Error Correction Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...

  • Page 57: Maintenance And Service

    The vacuum sensor is maintenance-free. Remove any soiling on the outside with a cloth. Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus Maintenance and Service...

  • Page 58: Rubber Valves

    Hardly detectable cracks on the surface expand and weaken the material without visible signs. When visible damage of the surface, a crack, Maintenance and Service Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...

  • Page 59: Maintenance Of The Drying Chamber

    Therefore, take care that no product or other residues will get into the pipe to the aeration valve and the drain valve. Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus Maintenance and Service...

  • Page 60: Disinfection Of Drying Chamber, Lid And Accessories

    Oil level of vacuum pump Accessories, especially changes like corrosion, wear and tear of material etc. Furthermore, an earth conductor check must be carried out regularly. Maintenance and Service Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...

  • Page 61: Service

    If you would like to utilise our service, please state the type of your freeze-dryer and its serial number Make use of our service request on the Internet. Please use the request form (see above) on our website. Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus Maintenance and Service...

  • Page 62: Return Of Defective Parts

    If the product is dispatched to us in unsuitable packaging, you will be charged the cost for returning it to you in new packaging. The forms can be downloaded online from www.martinchrist.de [Service Area]. Maintenance and Service Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...

  • Page 63: Process Control System Lpc-32, Software

    8.5. Electrical lifting device Only for ALPHA 1-4/2-4 LSC GAMMA 1-16 LSC / 2-16 LSC and DELTA 1-24 LSC / 2-24 LSC ALPHA 1-4/2-4 LDplus BETA 1-8/2- 8LDplus Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus Options...
  • Page 65 Operating manual of the vacuum pump (only in case of delivery) Operating manual of the exhaust filter (only in case of delivery) Operating manual of the vacuum sensor (only in case of delivery) Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus Enclosures...
  • Page 67 Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus Enclosures...
  • Page 69 Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus Enclosures...
  • Page 70 Enclosures Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...
  • Page 71 Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus Enclosures...
  • Page 72 Enclosures Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...
  • Page 73 Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus Enclosures...
  • Page 74 Enclosures Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...
  • Page 75 Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus Enclosures...
  • Page 76 Enclosures Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...
  • Page 77 Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus Enclosures...
  • Page 78 Enclosures Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...
  • Page 79 Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus Enclosures...
  • Page 80 Enclosures Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...
  • Page 81 Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus Enclosures...
  • Page 82 Enclosures Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...
  • Page 83 Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus Enclosures...
  • Page 84 Enclosures Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus...
  • Page 85 Донау Лаб. Москва/ «Donau Lab. Moscow» - дилер Mar Тел. +7 (495)-255-33-89 Адрес: 119 034, Москва, Турчанинов пер, д.6, стр.2 www.donaulab.ru tin Christ GmbH Посмотреть каталог оборудования Mar Operating Manual Freeze Dryer ALPHA 1-4 LDplus / ALPHA 2-4 LDplus Enclosures...

This manual is also suitable for:

Alpha 2-4 ldplus

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