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Christ Beta 1-8 LSCplus Operating Manual

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Translation of the original operating manual
sb-dc
Freeze-dryer
Rev. 2.9 of 09/03/2020
Beta 1-8 LSCplus;Freeze-dryer;Beta 2-8 LSCplus
Version 04/2013
Beta 1-8 LSCplus
Part no. 102124, 102126, 102128, 102130, 102132, 102134
Beta 2-8 LSCplus
Part no. 102125, 102127, 102129, 102131, 102133, 102135
Operating Manual
Freeze-dryer
Please retain for later use!

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  • Page 1 Translation of the original operating manual sb-dc Freeze-dryer Rev. 2.9 of 09/03/2020 Beta 1-8 LSCplus;Freeze-dryer;Beta 2-8 LSCplus Version 04/2013 Beta 1-8 LSCplus Part no. 102124, 102126, 102128, 102130, 102132, 102134 Beta 2-8 LSCplus Part no. 102125, 102127, 102129, 102131, 102133, 102135...
  • Page 2 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus Version 04/2013, Rev. 2.9 of 09/03/2020 • sb-dc 2 / 125 Translation of the original operating manual...
  • Page 3 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus In case of inquiries, please state the following numbers: Order number: Serial number: © Copyright by Martin Christ Gefriertrocknungsanlagen GmbH An der Unteren Söse 50 37520 Osterode am Harz Germany Tel.: +49 (0) 5522 / 5007-0...
  • Page 4 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus Version 04/2013, Rev. 2.9 of 09/03/2020 • sb-dc 4 / 125 Translation of the original operating manual...

  • Page 5: Table Of Contents

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus Table of contents General information ......................9 Importance of the operating manual .................. 9 Intended use ........................9 Warranty and liability....................... 11 Copyright ........................12 Explanation of symbols ....................12 Standards and regulations ....................12 Scope of supply ......................
  • Page 6 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus Table of contents Safety devices ........................ 30 3.8.1 System check ......................30 3.8.2 Earth conductor check ....................30 Procedures in the event of hazards and accidents ............31 3.10 Maintenance and cleaning of the freeze-dryer ..............31 3.11...
  • Page 7 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus Table of contents 6.5.3 Option: freeze-drying with the PGMplus programmer module ........71 6.5.3.1 Creating a program .................... 75 6.5.3.2 Editing a program ....................80 6.5.3.3 Copying a program .................... 81 6.5.3.4 Loading a program .....................
  • Page 8 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus Table of contents Appendix .......................... 104 11.1 Mathematical relations ....................104 11.2 Brief operating instructions ................... 105 11.3 EC declaration of conformity in accordance with the EC Machinery Directive ....111 Declaration of conformity – China RoHS 2 ..............113 11.4...

  • Page 9: General Information

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 1 General information → General information → Importance of the operating manual A fundamental requirement for the safe and trouble-free operation of the unit is to be familiar with the fundamental safety instructions and all possible hazards.
  • Page 10 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 1 General information The following table can be used as a general guide for the expected degradation during normal freeze-drying processes of organic solvents with a total max. concentration of 10 vol-% in aqueous solutions.

  • Page 11: Warranty And Liability

    Any other use beyond this area of application is regarded as improper use. Martin Christ Gefriertrocknungsanlagen GmbH cannot be held liable for any damage resulting from such improper use.

  • Page 12: Copyright

    Freeze-dryer Beta 2-8 LSCplus 1 General information → Copyright The copyright concerning the operating manual remains with Martin Christ Gefriertrocknungsanlagen GmbH. The operating manual is solely intended for the operator and their personnel. It includes instructions and information that may not be •...

  • Page 13: Layout And Mode Of Operation

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 2 Layout and mode of operation → Layout and mode of operation → Layout of the freeze-dryer → 2.1.1 Functional and operating elements Ice condenser chamber LSCplus user interface (see chapter 6.5.1 - "User interface")
  • Page 14 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 2 Layout and mode of operation Contact piece Pipe connection of the vacuum sensor Pipe connection of the vacuum pump (behind the cover plate) Ice condenser Fig. 3: Ice condenser chamber Mains power switch Fig.

  • Page 15: Name Plate

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 2 Layout and mode of operation 11 Heat exchanger of the refrigeration unit 12 Name plate (see chapter 2.1.2 - "Name plate") 13 Vacuum connection 14 Serial interface 15 Electrical connection of the vacuum sensor...

  • Page 16: Mode Of Operation

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 2 Layout and mode of operation → Mode of operation → 2.2.1 General information on freeze-drying What is freeze-drying? Freeze-drying or lyophilisation is a procedure for the gentle drying of high- quality products. The product is dried by → sublimation without passing through the liquid phase.
  • Page 17 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 2 Layout and mode of operation Fig. 8: Vapour pressure curve for ice and water From a physical point of view, the freeze-drying process covers three phases (see figure below): (1) Freezing: The product to be dried is frozen under atmospheric pressure.
  • Page 18 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 2 Layout and mode of operation Fig. 9: Freeze-drying phases Please find further information about basic principles, optimum procedures and applications in the brochure "Smart freeze-drying", which can be downloaded at www.martinchrist.de → [Applications] →...

  • Page 19: Freeze-Drying Process

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 2 Layout and mode of operation 2.2.2 Freeze-drying process The main components of a freeze-dryer are: • vacuum drying chamber or drying manifold, • vacuum pump for generating a vacuum inside the drying chamber, •...

  • Page 20: Main Drying

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 2 Layout and mode of operation 2.2.2.3 Main drying When the product is frozen, the main drying phase commences. The vacuum pump is switched on. The pressure inside the drying chamber will...

  • Page 21: Defrosting

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 2 Layout and mode of operation 2.2.2.6 Defrosting Defrosting with hot gas As standard, the freeze-dryer is equipped with a hot-gas defrosting system. In order to defrost the ice condenser, heated refrigerant is fed through the heating coil.

  • Page 22: Safety

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 3 Safety → Safety → Marking of the unit The following symbols are used for Christ freeze-dryers: Dangerous voltage On (Power) Hot surface Off (Power) Name plate (see chapter Caution! Risk of bruising 2.1.2 - "Name plate")

  • Page 23: Explanation Of The Symbols And Notes

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 3 Safety → Explanation of the symbols and notes This operating manual uses the following names and symbols to indicate hazards: This symbol stands for a direct hazard to the life and health of persons.

  • Page 24: Responsibility Of The Operator

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 3 Safety → Responsibility of the operator Operating personnel The operator is obliged to ensure that the persons working on/with the freeze-dryer • are 18 years old or older, • have been specifically ordered to do so by the operator/owner and that...

  • Page 25: Operating Personnel

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 3 Safety • concerning the chamber pressure and shelf temperature for every product that is to be processed in the freeze-dryer, • concerning the inspection of the freeze-dryer in view of damage caused by the solvent that is used (see chapter 1.2 - "Intended use", section...

  • Page 26: Safety Notes Concerning The Transport, Set-Up And Connection And Initial Start-Up Of The Freeze-Dryer

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 3 Safety Safety notes concerning the transport, set-up and connection and initial start-up of the freeze-dryer The following notes and instructions must be observed in order to protect all persons and property.

  • Page 27: Hazards Caused By Improper Connection

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 3 Safety 3.6.4 Hazards caused by improper connection Risk of injury caused by consequences of improper connection Improper connection may lead to a hazardous electrical incident at a later time during the operation of the freeze-dryer.

  • Page 28: Hazards Caused By The Refrigeration System (Natural, Flammable Refrigerants)

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 3 Safety 3.7.2 Hazards caused by the refrigeration system (natural, flammable refrigerants) Risk of explosion due to refrigerants The refrigerants used are highly flammable and can form an explosive mixture if their concentration in the ambient air is sufficiently high.

  • Page 29: Hazards Caused By Harmful Products

    This may lead to severe injuries. DANGER Freeze-drying of products containing acids is only permissible if special protective measures and equipment-related precautions are taken! Consultation of Martin Christ Gefriertrocknungsanlagen GmbH is absolutely mandatory in order to define the measures that need to be taken! •...

  • Page 30: Hazards Caused By Contaminated Condensate (Defrosting Water)

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 3 Safety 3.7.7 Hazards caused by contaminated condensate (defrosting water) Risk of poisoning/infection caused by contaminated condensate (defrosting water) The condensate may contain harmful substances originating from the product. WARNING Contact with the condensate may cause severe damage to health.

  • Page 31: Procedures In The Event Of Hazards And Accidents

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 3 Safety → Procedures in the event of hazards and accidents Hazardous electrical incident: • Set the control switch to the "0" position in order to interrupt the power supply completely. Fire: •...

  • Page 32: Measures To Be Taken To Ensure Safe Operation Of The Freeze-Dryer

    • Stop the freeze-dryer immediately in the event of a malfunction. Eliminate the malfunction (see chapter 7 - "Malfunctions and error correction") or contact the after-sales service of Firma Martin Christ Gefriertrocknungsanlagen GmbH (see chapter 7.3 - "Service contact"). •...

  • Page 33: Remaining Hazards

    → 3.12 Remaining hazards All Christ freeze-dryers were built state-of-the-art and according to the accepted safety rules. Danger to life and limb of the operator, or of third parties, or impairments of the units or other material assets, however, cannot be completely excluded when the units are being used.

  • Page 34: Storage And Transport

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 4 Storage and transport → Storage and transport → Dimensions and weight Values for the freeze-dryer without a vacuum pump: Beta 1-8 LSCplus Beta 2-8 LSCplus Height: 415 mm 415 mm Width:...

  • Page 35: Notes On Transport

    Do not grab the unit at the plastic control panel (see figures below). correct incorrect Fig. 10: Lifting the freeze-dryer The freeze-dryer Beta 1-8 LSCplus weighs approx. 63 kg! The freeze-dryer Beta 2-8 LSCplus weighs approx. 78 kg! CAUTION The centre of gravity of the freeze-dryer is off-centre! CAUTION •...

  • Page 36: Packaging

    Lift the freeze-dryer upwards and out of the crate/cardboard box. When lifting the unit, always reach under the freeze-dryer from the side. The freeze-dryer Beta 1-8 LSCplus weighs approx. 63 kg! The freeze-dryer Beta 2-8 LSCplus weighs approx. 78 kg!

  • Page 37: Set-Up And Connection

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 5 Set-up and connection → Set-up and connection → Location of use Use the freeze-dryer solely in closed and dry spaces. Refrigeration problems of the freeze-dryer are often caused by insufficient conditions at the location of use. This is why compliance with the following...

  • Page 38: Power Supply

    The operating voltage on the name plate must correspond to the local supply voltage! DANGER Christ freeze-dryers are units of protection class I. Freeze-dryers of this type have a three-wire power cord with an IEC C13 connector (see chapter 10 - "Technical data").

  • Page 39: Media Drain Valve

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 5 Set-up and connection → Media drain valve Risk of poisoning/infection caused by contaminated condensate (defrosting water) The condensate may contain harmful substances originating from the product. WARNING Contact with the condensate may cause severe damage to health.
  • Page 40 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 5 Set-up and connection • Take the vacuum sensor out of its original packaging and fasten it to the connector with a bow-shaped connecting piece, two clamping rings (DIN16KF) and two centring rings (included in the scope of supply).

  • Page 41: Vacuum Pump

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 5 Set-up and connection Vak uumpumpe → 5.4.6 Vacuum pump It is absolutely essential to refer to the separate instruction manual of the vacuum pump and exhaust filter (if applicable)! NOTE The vacuum pump must be connected to the vacuum connection of the unit and to the electrical socket at the back of the unit, which is marked accordingly (see chapter 2.1.1 - "Functional and operating elements").

  • Page 42: Pressure Control Valve

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 5 Set-up and connection → Pressure control valve The pressure control valve is integrated in the suction pipe between the vacuum pump and ice condenser chamber. During certain, specified process phases, it interrupts the volume flow to the vacuum pump (see chapter 2.2.1 - "General information on freeze-drying")

  • Page 43: Rubber Valves

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 5 Set-up and connection → Rubber valves The rubber valves (part no. 121860) enable the connection of round-bottom flasks, wide-neck filter bottles, or distributors for ampoules to a manifold or drying chamber. Depending on the connector of the components, the blue plug can be removed.

  • Page 44: Operation

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation Operation Initial start-up Before the initial start-up, please ensure that your freeze-dryer is properly set up and installed (see chapter 5 - "Set-up and connection") WARNING → Installation of accessories The accessories must be completed in accordance with the drying method that is applied as well as in accordance with the scope of supply.

  • Page 45: Lscplus Control System

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation LSCplus control system The control system LSCplus (Lyo Screen Control plus) was specifically developed for the control of freeze-drying processes. The clear user interface enables the intuitive operation of the unit.

  • Page 46: Main Window "Manual

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation The user interface is divided into four main windows that can be called up by touching the corresponding buttons: Manual This window is also the standard user interface. It is used to control the freeze-drying process manually.
  • Page 47 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation Status line (1) This line shows the operating status of the freeze-dryer as well as the active phase. The status line also shows the current date and time. The clock is battery- buffered and must be reset after a failure (chapter 6.5.1.3 - "Main window...
  • Page 48 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation Actual values of the current process (4) This area shows the current process data. The fields can be configured as desired: • Select the button of the field that is to be adapted. A dialog box opens: Fig.
  • Page 49 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation Option: USB process recording (see chapter 6.6 - "Optional extensions") • Select the "Process recording" function in the dialog box "Tools". • Select the input fields ("Batch data"). A keyboard for the data input will be displayed.
  • Page 50 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation Fig. 24: Dialog box “Pressure increase test” • The "Test stop" button stops the pressure increase test. Dialog box "Schematic system diagram" (6) Pressing the button "Schematic system diagram" displays a schematic diagram of the system on the left-hand side of the screen, including all the components.
  • Page 51 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation Dialog box "Process and equipment messages" (7) This dialog box shows and saves all of the error messages and other messages. In the event of an error or message, the window “Process and equipment messages”...
  • Page 52 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation Details Touching the message calls up details concerning the error message: • Cause of the message • Effects of the message • Measures to eliminate the error → Reference designator •...
  • Page 53 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation Fig. 29: Dialog box "Operating mode: select/start" (The version of the dialog box that is displayed depends on the equipment of the freeze-dryer.) Standard unit test Apart from the process phases of the freeze-drying process ("Freezing", "Warm-up", "Main drying", and "Final drying") and the operating mode...
  • Page 54 Fig. 31: Results of the performance tests Evaluation: Please contact the Martin Christ Gefriertrocknungsanlagen GmbH for an assessment of the results. Version 04/2013, Rev. 2.9 of 09/03/2020 • sb-dc 54 / 125...
  • Page 55 • Select "Leakage test" and start the test via the "Run" button. The parameters for the leakage test have been developed by Martin Christ Gefriertrocknungsanlagen specifically for the freeze-dryers. In a first step, these parameters (vacuum, ice condenser temperature) must be reached.

  • Page 56: Main Window "Program

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation 6.5.1.2 Main window "Program" In the main window "Program", pre-programmed freeze-drying processes can be loaded and edited and new programs can be created with the PGMplus programmer module. For this function, the PGMplus programmer module must be available.

  • Page 57: Main Window "Options

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation 6.5.1.3 Main window "Options " The main window "Options" is used to perform fundamental basic settings of the control system in order to adapt it perfectly to the respective area of application of the freeze-dryer.
  • Page 58 • Double chamber method LyoCube (outside): drying outside the ice condenser chamber, but with the CHRIST LyoCube (a rectangular drying chamber that can be loaded from the front) Fig. 36: Dialog box "Freeze-drying processes" Version 04/2013, Rev. 2.9 of 09/03/2020 • sb-dc...
  • Page 59 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation Administration “Administration” options: "Date/Time" "Network" "System properties" "Access protection" "Device options" "Configuration of sensors" Abb. 37: Dialogfenster "Optionen" / Verwaltung Date/Time (1) The LSC control system is equipped with an integrated, battery-buffered plus clock.
  • Page 60 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation Network (2) This dialog box is used to change various system settings. The modifications will not become effective until after a restart of the unit. NOTE Fig. 39: Dialog box "Network"...
  • Page 61 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation Behaviour of the pressure control valve in the case of insufficient ice condenser cooling: If this function is active (button "closed"), the pressure control valve will close at an ice condenser temperature of ≥...
  • Page 62 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation • The button with the lock symbol blocks the access immediately and the system switches to the default setting. Fig. 43: Access blocked, the data cannot be edited User/maintenance/administrator password: For each of these access levels, certain editing rights have been defined.
  • Page 63 • Press the button "Add option". An input window opens. • Enter the six-digit Christ activation code that was supplied for this option. Note that the keys are case sensitive. Options can be removed in the same way. The modifications will not become effective until after a restart of the unit.
  • Page 64 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation Service “Service” options: "Operating hours" "Failure memory" "Wireless shelf technology" "Vacuum pump oil change" "Maintenance" "Sensor adjustment" Fig. 46: Dialog box "Service" (varies depending on the type of system) Operating hours (1) This dialog box is used to call up the number of operating hours of the various components of the freeze-dryer, e.g.
  • Page 65 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation Always indicate the error code in the event of enquiries or service requests! NOTE Fig. 48: Dialog box "Failure memory" Wireless shelf technology (3) This function depends on the unit type and is not available for all types of freeze-dryers.
  • Page 66 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation • In order to assign an address, open the dialog box "Wireless Shelf Technology". • Ensure that only the WST module to which an address is to be assigned is connected. If several modules are connected, they will all receive the same address, resulting in a communication conflict.
  • Page 67 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation Fig. 51: Dialog box "Maintenance" Sensor adjustment (6) In this dialogue box, the sensors are adjusted based on a predefined reference value. Sensors that are not properly adjusted will lead to incorrect measurements which, in turn, will have a negative effect on the process control.

  • Page 68: Main Window

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation 6.5.1.4 Main window "?" This main window includes the most important information concerning your freeze-dryer: Freeze-dryer type Control system type Serial number Manufacturer contact data Details concerning the software version Fig.

  • Page 69: Entering Set Values In The Manual Mode

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation If in one section the value "∞" (infinite) is selected for a process phase, the next phase must be started manually via the button "Operating mode: select/start". NOTE In the manual mode, the set values of the active phase can be changed during the process run.
  • Page 70 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation Viewing or editing the set values: • Press the button "Set values: view/edit" (see chapter 6.5.1.1 - "Main window "Manual""). The following dialog box will be displayed: "Aeration" button "Defrosting" button "Media drain"...

  • Page 71: Option: Freeze-Drying With The Pgmplus Programmer Module

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation Numerical values can be edited with the aid of a numerical keypad: Set value display Button for changing the sign (e.g. when entering temperature values) "" (infinite) Button for editing the...
  • Page 72 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation Fig. 56: Representation of a freeze-drying program Program sections When the programmer module executes a freeze-drying process, it executes the various sections that were created one after the other until the last section is completed.
  • Page 73 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation Conditions for switching to the next section For all of the program sections to be executed automatically, certain switching conditions must be fulfilled at the end of each section. If these conditions are not fulfilled, e.g.
  • Page 74 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation Vacuum pump warm-up Apart from the execution of the various sections, the PGMplus programmer module also controls other tasks that need to be performed during the process run, e.g. the automatic activation of the vacuum pump.

  • Page 75: Creating A Program

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation 6.5.3.1 Creating a program To create a new program: • Press the button "New program" in the main window "Program". The dialog box that is displayed offers various different program templates.
  • Page 76 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation “Program” buttons: "Program" "Program name" "Show diagram " "Insert section " "Delete section " Button for calling up more functions and set values "Save" Fig. 60: Editing a blank program template •...
  • Page 77 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation Button ">>more" The button ">>more" can be used to enter more functions and set values in a program-related manner. Fig. 61: Selection of program-related functions and set values Vacuum pump warm-up See chapter 6.6 - "Optional extensions"...
  • Page 78 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation Otherwise, a process message will be issued, the current section will be extended, and further pressure increase tests will be executed periodically until the condition is fulfilled. If the actual value exceeds the set value before the preselected time has elapsed, the test will be aborted in order to prevent the product from thawing.
  • Page 79 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation Option: Comparative pressure measurement (see chapter 6.6 - "Optional extensions") The indication of the measurement value "dp Comp" can be configured in chapter 6.5.1.1 - "Main window "Manual""under "Actual values of the current process"...

  • Page 80: Editing A Program

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation Program templates (2) The PGMplus programmer module offers 14 different program templates that include recipes for all kinds of freeze-drying applications. They are suggestions for orientation purposes and must be adapted to the specific area of application of the freeze-dryer.

  • Page 81: Copying A Program

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation 6.5.3.3 Copying a program If a new program is to be created based on an already existing program, the already existing program can be copied. A free program storage location must be available for this purpose.

  • Page 82: Deleting A Program

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 6 Operation Fig. 66: The freeze-drying process can be started with the aid of the button “Program start”. • During the freeze-drying process, the description of the active program can also be called up from the main window "Program" and via the button "Info".

  • Page 83: Optional Extensions

    Since absolutely tight components simply do not exist, a leak rate is determined. The parameters for the leakage test have been developed by Martin Christ Gefrier- trocknungsanlagen specifically for freeze-dryers. In a first step, these parameters (vacuum, ice condenser temperature) must be reached.

  • Page 84: Switching The Freeze-Dryer Off

    LPCplus SCADA system The Christ LPCplus system consists of the Supervisory Control And Data Acquision (SCADA) software program by Martin Christ Gefriertrocknungs- anlagen GmbH and a dedicated PC. The system is connected to the...

  • Page 85: Malfunctions And Error Correction

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 7 Malfunctions and error correction → Malfunctions and error correction Malfunctions are displayed in the dialogue box "Process & equipment messages" (see chapter 7.2 - "Process and error messages"). An acoustic signal sounds when an error message is generated.

  • Page 86: Power Failure

    (see chapter 7.3 - "Service contact") If it is impossible to eliminate the errors, contact the Christ service department! NOTE → 7.1.1 Power failure The control system continues with the process after a power failure.

  • Page 87: Insufficient Vacuum

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 7 Malfunctions and error correction → 7.1.2 Insufficient vacuum The vacuum checks must be carried out when the ice condenser is frozen. NOTE → 7.1.2.1 Small flange connections Leakages are often due to improper small flange connections between the various components and hose connections or to leakages in the valves.

  • Page 88: Aeration Valve, Media Drain Valve

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 7 Malfunctions and error correction → 7.1.2.2 Aeration valve, media drain valve Risk of poisoning/infection caused by contaminated condensate (defrosting water) The condensate may contain harmful substances originating from the product. WARNING Contact with the condensate may cause severe damage to health.

  • Page 89: Insufficient Ice Condenser Temperature

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 7 Malfunctions and error correction → 7.1.3 Insufficient ice condenser temperature Ensure sufficient ventilation. Do not place any paper, cloth, or similar material behind or under the unit, since otherwise the air circulation will be impaired.

  • Page 90: Service Contact

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 7 Malfunctions and error correction → Service contact In the event of queries, malfunctions, or spare part enquiries: From Germany: Contact Martin Christ Gefriertrocknungsanlagen GmbH An der Unteren Söse 50 37520 Osterode (Germany) Tel.

  • Page 91: Maintenance And Service

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 8 Maintenance and service → Maintenance and service The freeze-dryer and the accessories are subject to high mechanical and chemical stress. Thorough maintenance performed by the user extends the service life and prevents premature failure.

  • Page 92: Ice Condenser Chamber

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 8 Maintenance and service Cleaning of the freeze-dryer • Switch the freeze-dryer off by actuating the mains power switch and disconnect the power cord from the wall outlet before cleaning. • If the freeze-dryer has been contaminated with toxic, radioactive, or...

  • Page 93: Aeration Valve, Media Drain Valve

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 8 Maintenance and service → 8.1.3 Aeration valve, media drain valve Risk of poisoning/infection caused by contaminated condensate (defrosting water) The condensate may contain harmful substances originating from the product. WARNING Contact with the condensate may cause severe damage to health.

  • Page 94: Heat Exchanger (Only For Air-Cooled Freeze-Dryers)

    • Check the heat exchanger at least once per month for soiling and clean it if necessary. • Please contact the Christ service department if you have any queries (see chapter 7.3 - "Service contact"). 8.1.5 Electrical system Danger of life caused by electric shock There is a risk of electric shock when touching current-carrying components.

  • Page 95: Exhaust Filter (Oil Mist Separator)

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 8 Maintenance and service → 8.1.7 Exhaust filter (oil mist separator) Please refer to the separate operating manual of the vacuum pump and the exhaust filter! NOTE The oil mist that is emitted by the vacuum pump in quantities that depend on the working pressure must be led to the outside or to an exhaust hood or similar.

  • Page 96: Vacuum Sensor

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 8 Maintenance and service → 8.1.9 Vacuum sensor Please refer to the separate operating manual of the vacuum sensor! NOTE The vacuum sensor has only a limited service life. Especially carbon- containing substances, e.g. alcoholic compounds, reduce the service life extremely.

  • Page 97: Disinfection Of The Drying Chamber And Accessories

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 8 Maintenance and service → Disinfection of the drying chamber and accessories If dangerous materials (e.g. infectious and pathogenic substances) are used, the freeze-dryer and accessories must be disinfected. DANGER  •...

  • Page 98: Service

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 8 Maintenance and service Service In the event of service work that requires the removal of the panels, there is a risk of electric shock or mechanical injury. Only qualified specialist personnel is authorised to perform this service work.
  • Page 99 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 8 Maintenance and service 1. Declaration of decontamination As a certified company and due to the legal regulations for the protection of our employees and of the environment, we are obliged to certify the harmlessness of all incoming goods.

  • Page 100: Disposal

    Freeze-dryer Beta 2-8 LSCplus 9 Disposal → Disposal → Disposal of the freeze-dryer Martin Christ Gefriertrocknungsanlagen GmbH is a registered manufacturer of electric and electronic devices that are solely intended for commercial use. • Comply with all local rules and regulations. →...

  • Page 101: 10 Technical Data

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 10 Technical data → 10 Technical data Manufacturer: Martin Christ Gefriertrocknungsanlagen GmbH An der Unteren Söse 50 37520 Osterode (Germany) Type: Beta 1-8 LSCplus Beta 2-8 LSCplus Part number: 102124 102125 Performance data:...
  • Page 102 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 10 Technical data Connection requirements Beta 1-8 LSCplus Beta 2-8 LSCplus (without vacuum pump and accessories) Pressure control valve connection: 230 V, 50/60 Hz, 20 VA max. 230 V, 50/60 Hz, 20 VA max.

  • Page 103: Ambient Conditions

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 10 Technical data 10.1 Ambient conditions → 10.1 Umgebungs beding ung en • Use in closed spaces • Altitudes up to 2,000 m • Ambient temperature between +5°C and +25°C • Maximum relative humidity of 80% •...

  • Page 104: 11 Appendix

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 11 Appendix → 11 Appendix → 11.1 Mathematical relations The automatic processes in the “Programmer module” menu (see chapter 6.5.3 - "Option: freeze-drying with the PGMplus programmer module") are based on the following considerations: T/°C...

  • Page 105: Brief Operating Instructions

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 11 Appendix → 11.2 Brief operating instructions Functional and operating elements: Ice condenser chamber LSCplus user interface Fig. 73: Total view of the freeze-dryer Touchpanel Fig. 74: User interface with touchpanel Version 04/2013, Rev. 2.9 of 09/03/2020 • sb-dc...
  • Page 106 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 11 Appendix Contact piece Vacuum sensor Pipe connection of the vacuum pump (behind the cover plate) Ice condenser Fig. 75: Ice condenser chamber Mains power switch Fig. 76: Right side of the freeze-dryer...
  • Page 107 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 11 Appendix Fig. 77: Left side of the freeze-dryer 11 Heat exchanger of the refrigeration unit 12 Name plate 13 Vacuum connection 14 Serial interface 15 Electrical connection of the vacuum sensor...
  • Page 108 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 11 Appendix 4 Switch the unit on 20 to 30 minutes prior to the start of the drying process in order to let the vacuum pump warm up. 5 Place the plate rack on the base plate.
  • Page 109 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 11 Appendix Step-by-step instructions – drying in a flask 1 Freeze the sample separately, e.g. in a deep-freeze. Ensure that the layer thickness of 1 to 2 cm is not exceeded, since otherwise the drying time needs to be extended.
  • Page 110 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 11 Appendix Ensure that no water gets into the pipe connection of the vacuum pump or vacuum sensor. CAUTION 12 Drain the defrosting water via the defrosting water valve on the left-hand side of the unit.

  • Page 111: Ec Declaration Of Conformity In Accordance With The Ec Machinery Directive

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 11 Appendix → 11.3 EC declaration of conformity in accordance with the EC Machinery Directive Version 04/2013, Rev. 2.9 of 09/03/2020 • sb-dc 111 / 125 Translation of the original operating manual...
  • Page 112 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 11 Appendix Version 04/2013, Rev. 2.9 of 09/03/2020 • sb-dc 112 / 125 Translation of the original operating manual...

  • Page 113: Declaration Of Conformity - China Rohs 2

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 11 Appendix Declaration of conformity – China RoHS 2 11.4 Version 04/2013, Rev. 2.9 of 09/03/2020 • sb-dc 113 / 125 Translation of the original operating manual...
  • Page 114 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 11 Appendix Version 04/2013, Rev. 2.9 of 09/03/2020 • sb-dc 114 / 125 Translation of the original operating manual...

  • Page 115: Ec Declaration Of Conformity In Accordance With The Pressure Equipment Directive

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 11 Appendix 11.5 EC declaration of conformity in accordance with the Pressure Equipment Directive Version 04/2013, Rev. 2.9 of 09/03/2020 • sb-dc 115 / 125 Translation of the original operating manual...
  • Page 116 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 11 Appendix Version 04/2013, Rev. 2.9 of 09/03/2020 • sb-dc 116 / 125 Translation of the original operating manual...

  • Page 117: Table Of The Sublimation Pressure Curve

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 11 Appendix 11.6 Table of the sublimation pressure curve °C = mbar °C = mbar °C = mbar °C = mbar 37.79 6.57 0.57 0.025 35.64 6.11 0.52 0.024 33.60 5.62 0.47 0.021...
  • Page 118 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 11 Appendix Version 04/2013, Rev. 2.9 of 09/03/2020 • sb-dc 118 / 125 Translation of the original operating manual...

  • Page 119: 12 Glossary

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus 12 Glossary 12 Glossary Comparative pressure measurement During the sublimation, i.e. when the concentration of water vapour molecules is rather high in the atmosphere, the value that is provided by the gas-type dependent vacuum sensor of the "Pirani" type (e.g. Thyracont VSP 62/63) deviates from the value that is provided by a capacitive vacuum sensor (e.g.
  • Page 120 Wireless Shelf Technology With the Wireless Shelf Technology (WST), Martin Christ Gefrier- trocknungsanlagen GmbH has developed a system for laboratory freeze- dryers that works without cable connections at the electrically heated shelves and other equipment parts.

  • Page 121: 13 Index

    Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus Index 13 Index Click on touch ..........60 Commissioning .......... 12 Access protection........61 Comparative pressure measurement ..... Accessories ......12, 32, 91, 96 ..........79, 83, 119 Accident prevention ........25 Compatibility test........
  • Page 122 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus Index Defrosting water, contaminated (hazards) ..Environmental protection ......25 ..........30, 39, 88, 93 Equipment connections ......102 Defrosting with hot gas....... 21 Equipotential bonding screw .. 15, 30, 38, 107 Deleting a program ........
  • Page 123 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus Index Hazards (products, harmful) ....... 29 Lyo Control measuring system ....84 Hazards (refrigeration system) ....28 LyoLogplus data logging software ....84 Hazards (set-up) ........26 Hazards (solvents) ........29 Main drying ..........20 Hazards (surfaces, cold) ......
  • Page 124 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus Index Notes on safety and hazards ....... 9 Pressure measurement, comparative ..83 Notes on transport ........35 Prevention of accidents ........ 9 Procedures in the event of hazards and accidents ..........31 Oil mist separator .........
  • Page 125 Freeze-dryer Beta 1-8 LSCplus Freeze-dryer Beta 2-8 LSCplus Index Sensor adjustment ........67 Topping-up of operating supplies ....31 Serial interface ........15, 107 Touchpanel ........13, 105 Serial number ......15, 68, 90, 98 Touchpanel does not react ......85 Service ..........

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