Adafruit ESP32-S3 Manual page 203

Now you can try uploading again!
Did you remember to select the new Port in the Tools menu since the bootloader
port has changed?
This time, you should have success!
After uploading this way, be sure to click the reset button - it sort of makes sure that
the board got a good reset and will come back to life nicely.
After uploading with Manual Bootloader - don't forget to re-select the old Port
again
It's also a good idea to try to re-upload the sketch again now that you've performed a
manual bootload to get the chip into a good state. It should perform an auto-reset the
second time, so you don't have to manually bootload again.
Finally, a Blink!
OK it was a journey but now we're here and you can enjoy your blinking LED. Next up,
try to change the delay between blinks and re-upload. It's a good way to make sure
your upload process is smooth and practiced.
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