Thermo Scientific Vanquish Installation Manual
Solvent monitor
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Summary of Contents for Thermo Scientific Vanquish
- Page 1 Vanquish Solvent Monitor Installation Guide 4822.3010-EN Revision 1.0 • January 2020...
- Page 2 Copyright © 2020 Thermo Fisher Scientific Inc. All rights reserved. Trademarks All trademarks are property of Thermo Fisher Scientific and its subsidiaries. Disclaimer Thermo Fisher Scientific Inc. provides this document to its customers with a product purchase to use in the product operation. The document is copyright protected; any reproduction of the whole or any part of this document is strictly prohibited, except with the written authorization of Thermo Fisher Scientific Inc.
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Page 3: Table Of Contents
Contents Contents 1 About this Manual ............... 5 2 Overview .................. 6 3 Installation................... 7 Scope of Delivery.................... 7 Rating Plate ...................... 7 Allowed Concentrations .................. 7 Installing the Solvent Monitor ................ 8 Connecting Signal Cables to the Solvent Monitor .......... 10 Connecting the Solvent Monitor Lines .............. 14 3.6.1 Short Solvent Monitor Lines.............. - Page 4 Contents 7 Specifications ................ 42 Performance Specifications .................. 42 Physical Specifications .................. 43 8 Ship Kit.................. 44 9 Consumables and Replacement Parts......... 46 Page 4 Solvent Monitor Installation Guide...
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Page 5: About This Manual
• About this Manual About this Manual This manual provides instructions for installation, set up, maintenance and troubleshooting. This manual is intended as a supplementary document to the Operating Manual for your pump. Refer to the Operating Manual for general safety information and the typographic conventions used throughout this manual. -
Page 6: Overview
• ePanel in the Chromeleon™ software • Chromeleon parameters If a Vanquish System Controller is also installed, the measured volumes can also be monitored via the Vanquish Display or an internet web browser. Page 6 Solvent Monitor Installation Guide... -
Page 7: Installation
The allowed salt concentration for the solvent monitor is 1 mol/L or less. NOTICE If the solvent monitor is used in a Vanquish Core system, observe the lower chloride concentration allowed for this system (refer to the Vanquish System Operating Manual). -
Page 8: Installing The Solvent Monitor
Figure 1: Recommended position of the solvent monitor If a Vanquish Display is also to be installed, refer to the Vanquish User Interface Installation Guide for information where to mount the Vanquish Display. The instructions below describe how to mount the solvent monitor at the right side of the front railing. - Page 9 • Installation If personnel other than a Thermo Fisher Scientific service engineer installs the device, follow the steps below. 1. Loosen the screw of the mounting bracket on the rear side of the solvent monitor. 2. Hook the mounting bracket of the solvent monitor onto the right side of solvent rack railing.
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Page 10: Connecting Signal Cables To The Solvent Monitor
Rating plate, indicating the serial number, part number, module name, revision number (if any), and the manufacturer's address System Interlink port Allows device communication and synchronization between the device and other modules in the Vanquish system. USB (Universal Serial Bus) port ("B" type connector) Allows: •... - Page 11 • Installation NOTICE • Never use defective communication cables. If you suspect that a cable is defective, replace the cable. • To ensure trouble-free operation, use only the cables provided by Thermo Fisher Scientific for connecting the device. Parts required The following parts are needed: •...
- Page 12 • Installation 5. Connect the other system modules using system interlink cables (see images below). The images below show the two possible system interlink connection configurations. In the left image, the solvent monitor is connected to the autosampler. In the right image, the solvent monitor is connected to the detector.
- Page 13 Detector to solvent monitor 6. If the column compartment is attached to the right side of the Vanquish system stack and if the system stack includes a detector: Detach the column compartment from the system stack (refer to the Operating Manual of the column compartment).
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Page 14: Connecting The Solvent Monitor Lines
3.6.1 Short Solvent Monitor Lines From each monitored solvent reservoir, draw only: • Solvent for modules of one Vanquish system containing one pump (one dual pump included) and one autosampler and that are attached to the solvent monitor • Small amounts of autosampler needle wash liquid Parts required •... - Page 15 • Installation • Parts not included in the ship kit: The table shows the necessary parts and the requirements. Needed part Capacities Maximum Remarks height Solvent • 0.25 L 34 cm Do not use air-tight caps, for reservoirs example, caps with air valves. •...
- Page 16 • Installation 3. Optional: Cut the dipstick of the solvent monitor line to length with the capillary cutter, so that the dipstick stands out of the solvent reservoir by only a few centimeters, with the dipstick being straight in the solvent reservoir. Although this step is optional, keep in mind that a small solvent reservoir may tilt with a low solvent level and a long dipstick.
- Page 17 • Installation 10. Adjust the dipstick so that the end cap rests on the bottom of the solvent reservoir and the dipstick is straight. Doing so ensures high measurement accuracy. Figure 9: Correctly placed dipstick in a solvent reservoir Description Dipstick End cap 11.
- Page 18 • Installation 12. Cut the solvent monitor line to length with the capillary cutter. Figure 10: Cutting the solvent monitor line to length Description Solvent line to the pump Solvent monitor line Location to cut the solvent monitor line to length with the capillary cutter 13.
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Page 19: Long Solvent Monitor Line
Long Solvent Monitor Line Into each monitored waste container, lead only: • The waste of modules of one Vanquish system containing one pump (one dual pump is supported) and one autosampler and that are attached to the solvent monitor •... - Page 20 • Installation Parts required • The following parts from the ship kit: Figure 12: Ship kit parts Description Long solvent monitor line with dipstick End cap Retaining guide Line labels Page 20 Solvent Monitor Installation Guide...
- Page 21 • Installation • Parts not included in the ship kit: The table shows the necessary parts and the requirements. Needed part Maximum Maximum Remarks capacity height Waste 10 L 34 cm Further requirements: container • Do not use air-tight caps, for example, caps with air valves.
- Page 22 • Installation 7. Insert the dipstick into the waste container until the end cap is slightly above the waste container bottom and tighten the cap onto the waste container. 8. Press the retaining guide into the cap. 9. Adjust the dipstick so that the end cap rests on the bottom of the waste container and that the dipstick is straight.
- Page 23 • Installation After you have turned on the system (refer to the Vanquish System Operating Manual), the solvent monitor is ready to operate. For general information on calibration and operation, see Notes on the Solvent Monitor Operation (} page 26). For information on solvent monitor operation parameters in the Chromeleon software, refer to the Chromeleon Help.
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Page 24: Operation
• Operation Operation This chapter describes the status indicators and provides general information about the operation. For operating the solvent monitor, pump firmware revision 2.00 or later is needed. Status Indicators The solvent monitor has status indicators for each channel and for the solvent monitor. - Page 25 Operating Issues (} page 35). The status of the solvent reservoirs and waste containers is also indicated on the ePanel and on the Vanquish Display. Messages in the Audit Trail give more background information on the status. Solvent Monitor Status Indicator The table describes the various statuses the solvent monitor status indicator can assume.
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Page 26: Operating Principle
• Operation Operating Principle The solvent monitor accurately measures the real-time consumption of each solvent and accumulation of HPLC waste using hydrostatic pressure. Initially, the solvent monitor measures the ambient pressure and then forces a small volume of air out of each activated channel port to determine the hydrostatic pressure at the bottom of the solvent reservoir/waste container. - Page 27 • Operation Solvent reservoir change or The calibration data acquired for the previous solvent reservoir will also subsequent power up be used for the following solvent reservoir. Depending on the next solvent and solvent reservoir size, the accuracy will be as follows: Situation Accuracy Remarks...
- Page 28 • Operation Recommendations for Operation Observe the following recommendations: • Before operation: Do not use air-tight caps (e.g. caps with air valves) as this will ¨ perturb the pressure measurement. Except for system configurations using dual pumps, solvent ¨ reservoir/waste container sharing is not supported. Do not lead additional liquid in the waste container or draw additional solvent from a solvent reservoir as this will disturb the calibration.
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Page 29: Maintenance And Service
• Maintenance and Service Maintenance and Service This chapter describes the routine maintenance and the service procedures that the user may perform. General Rules for Maintenance and Service For successful maintenance and service procedures, follow these rules and recommendations: • Before starting maintenance or service procedures, turn off the power supply by unplugging the USB cable. -
Page 30: Routine And Preventive Maintenance
• Maintenance and Service Routine and Preventive Maintenance 5.2.1 Maintenance Plan Perform the maintenance procedures in the table on a regular basis. The frequency given in the table is a suggestion. The optimum frequency for maintenance depends on several factors, such as the types and amounts of samples and solvents or buffer solutions used with the device. - Page 31 • Maintenance and Service Preparations 1. Turn off the pump flow and wait until the system pressure is down to zero. Follow these steps 1. Unscrew the cap of the solvent reservoir/waste container and remove the solvent monitor line together with the cap from the solvent reservoir/waste container.
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Page 32: Replacing The End Caps
• Maintenance and Service Replacing the End Caps When • End cap is: Contaminated ¨ Discolored or otherwise damaged ¨ • Semiannually Parts required Replacement end cap Preparations 1. Turn off the pump flow and wait until the system pressure is down to zero. -
Page 33: Replacing The Retaining Guides
• Maintenance and Service Replacing the Retaining Guides When Retaining guide is damaged. Parts required Replacement retaining guides Preparations 1. Turn off the pump flow and wait until the system pressure is down to zero. Follow these steps 1. Unscrew the cap of the solvent reservoir/waste container and remove the solvent monitor line together with the cap from the solvent reservoir/waste container. -
Page 34: Updating The Device Firmware
• Maintenance and Service Updating the Device Firmware When Updating the device firmware might be required, for example, when a new firmware version is released that adds functionality or solves problems of a previous version. Items required Firmware version/Chromeleon version as appropriate TIP When a new firmware version is released, the new version will be included in the next available Chromeleon version. -
Page 35: Troubleshooting
Thermo Fisher Scientific Technical Support for assistance. See the contact information at the beginning of the Vanquish System Operating Manual. To facilitate device identification, have the product name and serial number available when communicating with Thermo Fisher Scientific. - Page 36 • Troubleshooting Volume estimation Symptom Possible cause Remedial actions Jump in the volume Initial volume estimation No remedial actions necessary estimation switched to the calibrated, Background information: After you start using the actual solvent reservoir/ solvent monitor or after having entered a new nominal waste container volume volume, the solvent monitor calculates the volume based on various assumptions.
- Page 37 • Troubleshooting Volume accuracy Symptom Possible cause Remedial actions Volume inaccuracy Wrong connection of solvent Connect the solvent monitor line to the correct solvent is above ±15% of monitor line reservoir/waste container (see solvent monitoring the nominal bottle channel assignment table in Short Solvent Monitor volume Lines...
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Page 38: Messages
• Troubleshooting Miscellaneous Symptom Possible cause Remedial actions Channel cannot be Refer to the error messages Refer to the remedies of the error messages in the activated in the Chromeleon Audit Chromeleon Audit Trail. Trail. Solvent drops in a Leaking solvent monitor line 1. - Page 39 For details, refer to the Contacting Us section at the beginning of the Vanquish System Operating Manual.
- Page 40 • Troubleshooting Message and Code Description and Remedial Action Code 1017 System Interlink connection The connection to a module via the system interlink has timed timeout. out. • Make sure the system interlink cable is attached to the solvent monitor and the autosampler/detector and that the system interlink cable is not damaged.
- Page 41 • Troubleshooting Message and Code Description and Remedial Action Code 1033 Repeating measurement to The solvent monitor repeats a measurement when there was an ensure accuracy. error during the previous measurement. A measurement will be repeated up to three times. If this error persists, refer to the remedies of the preceding error messages.
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Page 42: Specifications
Communication 1 USB port (USB 2.0, "B" type connector) 1 system interlink port (RJ45-8 connector) Control and user interface Chromeleon 7 (and Vanquish User Interface) and status indicators on the solvent monitor Wetted materials PEEK For information about the chemical resistance of materials, refer to the technical literature. -
Page 43: Physical Specifications
• Specifications Physical Specifications The physical conditions of the device are specified as follows: Type Specification Range of use Indoor use only Ambient operating 5 °C - 35 °C temperature Ambient storage temperature -20 °C - 45 °C Ambient operating humidity 20% - 80% relative humidity (non-condensing) Ambient storage humidity Maximum 60% relative humidity (non-condensing) Operating altitude... -
Page 44: Ship Kit
• Ship Kit Ship Kit Ship kit 4-Channel Version Item Quantity in shipment Cable cover Cables, system interlink Cables, USB Capillary cutter End cap Line label 1 pack Line sleeve, with small diameter Line sleeve, with big diameter Retaining guide Solvent monitor lines, short (for solvent reservoirs) Solvent monitor lines, long (for waste containers) For reordering information, see... - Page 45 • Ship Kit 8-Channel Version Item Quantity in shipment Cable cover Cables, system interlink Cables, USB Capillary cutter End cap Line label 1 pack Line sleeve, with small diameter Line sleeve, with big diameter Retaining guide Solvent monitor lines, short (for solvent reservoirs) Solvent monitor lines, long (for waste containers) For reordering information, see Consumables and Replacement Parts...
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Page 46: Consumables And Replacement Parts
• Consumables and Replacement Parts Consumables and Replacement Parts The device must be operated only with the replacement parts specifically authorized and qualified by Thermo Fisher Scientific. Replacement parts are always maintained at the latest technical standard. Therefore, part numbers are subject to change. If not otherwise stated, updated parts will be compatible with the parts they replace. - Page 47 www.thermofisher.com Thermo Fisher Scientific Inc. 168 Third Avenue Waltham Massachusetts 02451...
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