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• 290°C for MassHunter Acquisition for TOF and Q-TOF B.05.00 or higher (still under
development and may change with final release).
• 150°C for MassHunter Acquisition for QQQ B.04.01 or higher.
The default Drying Gas Flow for all applications shall be:
• 6490 iFunnel QQQ – 11 L/min for all applications. Higher flows will lead to over drying
of the Nanospray and spray stability issues. Lower gas flows will lead to increased
chemical/droplet noise
• 6550 iFunnel Q-TOF – 9 L/min for most applications. Still under development and may
change with final release.
The default Capillary Voltage for all applications shall be:
• 1600 V starting point. With flow from the Nano Pump, increase the Capillary Voltage in
steps of 25 V to obtain stable spray. Once spray has been established, increase the
voltage by another 50 V. This will provide margin to account for ionization differences
when the HPLC solvent gradient changes. However, do not exceed 2100 V or the tip of
the HPLC Chip will be permanently damaged by the formation of an APCI Coronal
discharge. This results in poor sensitivity for the application.
Page 23 of 33
18 July 2011
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