Ducati SUPERBIKE 1299 PANIGALE S Owner's Manual page 269

Attention
Riding the motorcycle in FLAT (F) position and
with a pillion rider may cause motorcycle instability.
Ducati strongly advises against riding the motorcycle
with rear suspension in FLAT (F) position and a pillion
rider.
Important
FLAT (F) position allows having several track
alignments, such as in racing versions.
PROGRESSIVE (P) position is recommended when
riding with a pillion rider.
P
F
Fig 169
267