Solvent Information - Agilent Technologies 1100 Series Reference Manual

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Safety Informations

Solvent Information

Observe the following recommendations on the use of solvents.
Flow Cell
Avoid the use of alkaline solutions (pH > 11) which can attack quartz and thus
impair the optical properties of the flow cell.
Solvents
Always filter solvents through 0.4 µm filters, small particles can permanently
block the capillaries. Avoid the use of the following steel-corrosive solvents:
• Solutions of alkali halides and their respective acids (for example, lithium
• High concentrations of inorganic acids like nitric acid, sulfuric acid
• Halogenated solvents or mixtures which form radicals and/or acids, for
• Chromatographic grade ethers, which can contain peroxides (for example,
• Solutions of organic acids (acetic acid, formic acid, and so on) in organic
• Solutions containing strong complexing agents (for example, EDTA,
• Mixtures of carbon tetrachloride with 2-propanol or THF.
196
iodide, potassium chloride, and so on).
especially at higher temperatures (replace, if your chromatography method
allows, by phosphoric acid or phosphate buffer which are less corrosive
against stainless steel).
example:
→ 2COCl
2CHCl + O
3 2
This reaction, in which stainless steel probably acts as a catalyst, occurs
quickly with dried chloroform if the drying process removes the stabilizing
alcohol.
THF, dioxane, di-isopropylether) such ethers should be filtered through dry
aluminium oxide which adsorbs the peroxides.
solvents. For example, a 1-% solution of acetic acid in methanol will attack
steel.
ethylene diamine tetra-acetic acid).
+ 2HCl
2
1100 Series TCC Reference Manual