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Waters Quattro Premier XE Operator's Manual

Combined appi and apci source
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Waters
Quattro Premier XE
Combined APPI and
APCI Source
Operator's Guide
71500112702/Revision A
Copyright © Waters Corporation 2007
All rights reserved

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  • Page 1 Waters Quattro Premier XE Combined APPI and APCI Source Operator’s Guide 71500112702/Revision A Copyright © Waters Corporation 2007 All rights reserved...

  • Page 2: Copyright Notice

    Corporation assumes no responsibility for any errors that may appear in this document. This document is believed to be complete and accurate at the time of publication. In no event shall Waters Corporation be liable for incidental or consequential damages in connection with, or arising from, its use.

  • Page 3: Customer Comments

    Customer comments Waters’ Technical Communications department invites you to tell us of any errors you encounter in this document or to suggest ideas for otherwise improving it. Please help us better understand what you expect from our documentation so that we can continuously improve its accuracy and usability.

  • Page 4: Contacting Waters

    Contacting Waters ® Contact Waters with enhancement requests or technical questions regarding the use, transportation, removal, or disposal of any Waters product. You can reach us via the Internet, telephone, or conventional mail. Waters contact information Contacting medium Information Internet The Waters Web site includes phone numbers for Waters locations worldwide.

  • Page 5: Considerations Specific To The Quattro Premier Xe Combined Appi And Apci Source

    Considerations specific to the Quattro Premier XE Combined APPI and APCI Source Solvent leakage hazard The source exhaust system is designed to be robust and leak-tight. Waters recommends you perform a hazard analysis, assuming a maximum leak into the laboratory atmosphere of 10% LC eluate.
  • Page 6 High temperature hazard To avoid burn injuries, avoid touching the source enclosure Warning: with your hand when operating or servicing the instrument. Mass spectrometer high temperature hazard Source enclosure assembly...

  • Page 7: Safety Advisories

    High voltage hazard Warning: • To avoid electric shock, do not remove the mass spectrometer’s protective panels. The components they cover are not user-serviceable. • To avoid nonlethal electric shock when the instrument is in Operate mode, avoid touching the areas marked with the high voltage warning symbol.

  • Page 8: Operating This Instrument

    Intended use Waters designed the Quattro Premier™ XE Combined APPI and APCI Source option instrument to be used with a Quattro Premier XE Mass Spectrometer. The instrument is intended for use as a research tool to deliver authenticated mass measurement in both MS and MS/MS modes.

  • Page 9: Quality Control

    When analyzing samples from a complex matrix such as soil, tissue, serum/plasma, whole blood, etc., note that the matrix components can adversely affect LC/MS results, enhancing or suppressing ionization. To minimize these matrix effects, Waters recommends you adopt the following measures: •...

  • Page 10: Ivd Authorized Representative Information

    IVD authorized representative information IVD authorized representative Waters Corporation (Micromass UK Limited) is registered in the United Kingdom with the Medicines and Healthcare Products Regulatory Agency (MHRA) at Market Towers, 1 Nine Elms Lane, London, SW8 5NQ. The reference number is IVD000167.

  • Page 11: Table Of Contents

    Trademarks ......................ii Customer comments .................... iii Contacting Waters ....................iv Safety considerations ..................iv Considerations specific to the Quattro Premier XE Combined APPI and APCI Source.................... v Safety advisories ....................vii Operating this instrument ................viii Symbols ......................viii Intended use.....................
  • Page 12 Warnings that apply to particular instruments, instrument components, and sample types ..................A-3 Caution symbol ....................A-5 Warnings that apply to all Waters instruments ......... A-5 Electrical and handling symbols ..............A-13 Electrical symbols ..................A-13 Handling symbols ..................A-14...
  • Page 13 B Materials of Construction and Compliant Solvents ..... B-1 Preventing contamination ................B-2 Items exposed to solvent ................B-2 Solvents used to prepare mobile phases ............ B-3 Index ..................... Index-1 Table of Contents...
  • Page 14 Table of Contents...

  • Page 15: Appi, Apci, And Dual Appi/Apci Modes

    APPI, APCI, and Dual APPI/APCI Modes This chapter describes the Quattro Premier™ XE Combined APPI and APCI Source operation modes. Contents Topic Page APPI mode APCI mode Dual APPI/APCI mode...

  • Page 16: Appi Mode

    APPI mode In atmospheric pressure photoionization (APPI) mode, the source is fitted with an APCI probe, and the APPI lamp drive assembly is advanced into the source. “APCI probe” on page 2-2 “APPI lamp drive assembly” on See also: page 2-2.

  • Page 17: Apci Mode

    APCI mode Atmospheric Pressure Chemical Ionization (APCI) produces singly-charged protonated or deprotonated molecules for a large range of nonvolatile analytes. In APCI mode, the source fitted with an APCI corona pin. The APPI lamp drive assembly is not used, and is retracted from the source. APCI mode APCI probe Sample cone...

  • Page 18: Dual Appi/Apci Mode

    Dual APPI/APCI mode Dual APPI/APCI mode enables rapid switching between ionization modes, and allows high throughput (for example, for sample screening). The standard corona pin is replaced with a specially-shaped dual APPI/APCI corona pin, so that the APPI lamp holder can be advanced into the source for dual APPI/APCI operation.

  • Page 19: The Combined Appi/Apci Source

    The Combined APPI/APCI Source This chapter describes the Quattro Premier XE Combined APPI and APCI Source components and how to install and remove the source. Contents Topic Page Combined APPI/APCI Source Installing the Combined APPI/APCI Source Removing the Combined APPI/APCI Source...

  • Page 20: Combined Appi/Apci Source

    The Combined APPI/APCI Source comprises an APCI probe and the APPI lamp drive assembly. APCI probe The APCI probe is the standard probe used by the Quattro Premier XE for APCI operation. The Waters Quattro Premier XE Mass Spectrometer Operator’s See also: Guide.
  • Page 21 Switching on the UV lamp (from the MassLynx™ Tune window) provides a constant photon output. The intensity of incident radiation upon the sample molecules is varied by manually adjusting the distance between the UV lamp and probe tip, using the handle on the APPI lamp drive assembly to move the whole assembly on its mounting shaft.
  • Page 22 APPI lamp drive assembly showing the UV lamp and repeller electrode APPI source enclosure side plate UV lamp Repeller electrode APPI lamp drive assembly fitted to the source enclosure Source enclosure APPI lamp drive APCI probe assembly Sample cone UV lamp and repeller electrode The Combined APPI/APCI Source...

  • Page 23: Installing The Combined Appi/Apci Source

    Installing the APPI lamp drive assembly and APCI probe To complete this procedure, you must perform a pressure test on the Note: source, as described in the Waters Source Pressure Test Unit Operator’s Guide. Required materials • Chemical-resistant, powder-free gloves •...
  • Page 24 To avoid puncture wounds, take care if removing an Warning: ESI probe; the probe tip is sharp. If an ESI probe is fitted, remove the probe. The Waters Quattro Premier XE Mass Spectrometer Operator’s See also: Guide. To avoid damage, do not apply any downward force to Caution: the source enclosure door while the door is open.
  • Page 25 15. Connect the APPI drive cable (part number 4170075CC1), between the APPI lamp drive assembly APPI electrical connection and the APPI connector on the instrument front panel. The Waters Quattro Premier XE Mass Spectrometer Operator’s See also: Guide. 16. Connect the HT cable (part number M955286BC1), between the APPI lamp drive assembly’s HV electrical connection and the HV connector on...

  • Page 26: Removing The Combined Appi/Apci Source

    Removing the APCI probe and APPI lamp drive assembly To complete this procedure, you must perform a pressure test on the Note: source, as described in the Waters Source Pressure Test Unit Operator’s Guide. Required materials • Chemical-resistant, powder-free gloves •...
  • Page 27 16. Tighten the three securing thumbscrews. 17. Close the source enclosure door, and fasten the securing clips. 18. Fit the required probe to the source. The Waters Quattro Premier XE Mass Spectrometer Operator’s See also: Guide. Removing the Combined APPI/APCI Source...
  • Page 28 19. Close the instrument’s front access door. To confirm the integrity of the source exhaust Warning: system, you must perform a pressure test on the source, as described in the Waters Source Pressure Test Unit Operator’s Guide. 20. Perform a pressure test on the source. 2-10...

  • Page 29: Operating In Appi, Apci, And Dual Appi/Apci Modes

    Operating in APPI, APCI, and Dual APPI/APCI Modes This chapter describes operation of the Quattro Premier XE Combined APPI and APCI Source. Contents: Topic Page Operating in APPI mode Operating in APCI mode 3-10 Operating in Dual APPI/APCI mode 3-13...

  • Page 30: Operating In Appi Mode

    Operating in APPI mode Required materials • Chemical-resistant, powder-free gloves • Lint-free cloth • Methanol or isopropyl alcohol • Needle-nose pliers To prepare the source for operation in APPI mode If the Combined APPI/APCI Source is not already fitted on the instrument, install it as described in “Installing the Combined APPI/APCI Source”...
  • Page 31 To avoid self-contamination with toxic and Warning: biohazardous materials, always wear chemical-resistant, powder-free gloves while handling the components. To avoid electric shock, ensure that the instrument is Warning: in standby while working with the instrument’s front access door open. To avoid burn injuries, take great care while working Warning: with the instrument’s front access door open.
  • Page 32 To confirm that the UV lamp is operating correctly On the MassLynx Tune window, click Ion Mode > APPI+. The MassLynx Tune window APPI+ Source tab Click to start the nitrogen flow. Click Press for Operate, and confirm that the instrument status indicator is green.
  • Page 33 Wait for three minutes for the desolvation gas to cool the probe. Click to stop the nitrogen flow. To make the HPLC pump and column connections On the MassLynx Tune window, click Press for Standby, and confirm that the instrument status indicator is red. To avoid self-contamination with toxic and Warning: biohazardous materials, always wear chemical-resistant,...
  • Page 34 Pump and column connections to the APCI probe Zero dead volume T-piece LC column APCI probe Syringe pump HPLC pump To obtain an ion beam and tune the instrument for APPI mode On the MassLynx Tune window, click Ion Mode > APPI+. On the APPI+ Source tab, set Repeller to 0 kV.
  • Page 35 APCI probe position Repeller electrode APCI probe Lamp window Sample cone tip Set the parameters to the recommended values shown in the following table. Recommended Tune window APPI+ Source tab parameters Parameter Recommended value Voltages Repeller (kV) 1.50 Cone (V) Extractor (V) RF Lens (V) Temperatures...
  • Page 36 Ion Energy 2 Multiplier* Collision Cell Pressure (mbar) * The value stated for Multiplier is typical; in practice, you should use the value determined by the Waters Field Service Engineer during installation of the instrument. Click to start the nitrogen flow.
  • Page 37 13. Select the correct syringe type. The Waters Quattro Premier XE Operator’s Guide. See also: 14. Set Syringe, Pump Flow to 10 µL/min. 15. Click to start the syringe pump. 16. On the Tune window, click the Function 1 box.

  • Page 38: Operating In Apci Mode

    • The probe is hot and may damage the UV lamp assembly. 20. Tune the instrument as detailed in the Waters Quattro Premier XE Mass Spectrometer Operator’s Guide. Also, optimize the UV lamp position, and adjust the Tune window Source tab Repeller (kV) parameter, to give the maximum peak intensity.
  • Page 39 Click to stop the nitrogen flow. To avoid self-contamination with toxic and Warning: biohazardous materials, always wear chemical-resistant, powder-free gloves while handling the components.The probe and source may be contaminated with biologically hazardous materials. To avoid electric shock, ensure that the instrument is Warning: in standby while working with the instrument’s front access door open.
  • Page 40 Caution: mode, ensure that the lamp drive assembly is fully retracted from the source enclosure. Obtain an ion beam and tune the instrument as described in the Waters Quattro Premier XE Mass Spectrometer Operator’s Guide. 3-12 Operating in APPI, APCI, and Dual APPI/APCI Modes...

  • Page 41: Operating In Dual Appi/Apci Mode

    Operating in Dual APPI/APCI mode Required materials • Chemical-resistant, powder-free gloves • Lint-free cloth • Methanol or isopropyl alcohol • Needle-nose pliers To prepare the source for operation in dual APPI/APCI mode If the Combined APPI/APCI Source is not already fitted on the instrument, install it as described in “Installing the Combined APPI/APCI Source”...
  • Page 42 To avoid self-contamination with toxic and Warning: biohazardous materials, always wear chemical-resistant, powder-free gloves at all times while handling the components. To avoid electric shock, ensure that the instrument is Warning: in standby while working with the instrument’s front access door open.
  • Page 43 Use the needle-nose pliers to fit the dual APPI/APCI corona pin into the mounting contact. Ensure that the pin tip aligns with the sample cone tip. Combined APPI/APCI corona pin alignment For clarity, the lamp drive assembly is not shown. Note: APCI probe Combined...
  • Page 44 APPI+/APcI+ Source tab Click to start the nitrogen flow. Click Press for Operate and confirm that the adjacent instrument status indicator is green. Click Switch Lamp On and confirm that the Lamp readback is green. Click Switch Lamp Off and confirm that the Lamp readback is red. Click Press for Standby, and confirm that the instrument status indicator is red.
  • Page 45 To obtain ion beams and tune the instrument for dual APPI/APCI mode On the MassLynx Tune window, click Ion Mode > APcI+ or Ion Mode > APPI+. Click Options > Multiple ion modes > Dual APPI/APcI. On the APPI+/APcI+ source tab, Function 1 Ion Mode drop-down list, click APPI.
  • Page 46 APPI/APCI mode, ensure that the UV lamp does not touch the dual APPI/APCI corona pin. Obtain an ion beam and tune the instrument for APCI mode. The procedure in the Waters Quattro Premier XE Operator’s See also: Guide. 3-18...
  • Page 47 To create an MS Method file In the MassLynx window, click the MS Method icon. MS Method Editor In the MS Method Editor, click to delete the current entry from the MS Method Editor. Click MS Function Editor Operating in Dual APPI/APCI mode 3-19...
  • Page 48 In the MS Function Editor, Ionization Mode drop-down list, click the required APPI ionization mode (APPI+ or APPI-). Enter the required parameters for the APPI acquisition in the other frames. Click OK. The MS Function Editor closes, and the parameters are now Result: included as the APPI entry in the MS Method Editor.

  • Page 49: Maintenance Procedures

    Maintenance Procedures This chapter describes the maintenance procedures for the Quattro Premier XE Combined APPI and APCI Source. Contents Topic Page General Maintenance schedule Safety and handling Removing O-rings and seals Changing the UV lamp bulb Cleaning the lamp window Replacing the APPI lamp drive assembly O-rings...

  • Page 50: General

    General Refer to the Waters Quattro Premier XE Mass Spectrometer Operator’s Guide for details about maintaining the corona pins, source, sample cone, and APCI probe. Maintenance schedule The following table lists periodic maintenance schedules that ensure optimum instrument performance. The maintenance frequencies shown apply to instruments that normally receive moderate use.

  • Page 51: Safety And Handling

    Safety and handling Bear in mind the following safety considerations when performing maintenance procedures. To avoid self contamination with toxic and Warning: biohazardous materials, always wear chemical-resistant, powder-free gloves at all times while handling the components. Many of the procedures in this chapter involve the Warning: removal of contaminating deposits using flammable or caustic agents.

  • Page 52: Changing The Uv Lamp Bulb

    Dispose of the O-ring or seal in accordance with local environmental regulations. Changing the UV lamp bulb To complete this procedure, you must perform a pressure test on the Note: source, as described in the Waters Source Pressure Test Unit Operator’s Guide. Required materials • Chemical-resistant, powder-free gloves •...
  • Page 53 APPI lamp drive assembly Source enclosure side plate PEEK™ insulator Repeller electrode Repeller electrode retaining screw Insulator retaining screw (2-off) To change the UV lamp bulb To avoid self contamination with toxic and Warning: biohazardous materials, always wear chemical-resistant, powder-free gloves at all times while handling the components.
  • Page 54 Remove the cover cap from the back of the lamp drive assembly. APPI lamp bulb Nylon tube Cover cap (removed from the lamp drive assembly) To avoid breaking the bulb, do not use a screwdriver to Caution: push the bulb out of the lamp drive assembly. Insert the length of 4-mm nylon tube through the back of the lamp drive assembly, and push the bulb forward.

  • Page 55: Cleaning The Lamp Window

    To confirm the integrity of the source exhaust Warning: system, you must perform a pressure test on the source, as described in the Waters Source Pressure Test Unit Operator’s Guide. 12. Fit the APPI lamp drive assembly to the source enclosure and perform a source pressure test.
  • Page 56 To avoid self contamination with toxic and Warning: biohazardous materials, always wear chemical-resistant, powder-free gloves at all times while handling the components. The probe and source may be contaminated with biologically hazardous materials. To avoid electric shock, ensure that the instrument is Warning: in standby while working with the instrument’s front access door open.

  • Page 57: Replacing The Appi Lamp Drive Assembly O-Rings

    Lamp mounting flange O-ring To complete this procedure, you will be required to perform a pressure Note: test on the source, as described in the Waters Source Pressure Test Unit Operator’s Guide. Removing the APPI lamp drive assembly O-rings Required materials •...
  • Page 58 Use the 2.5-mm Allen wrench to remove the two insulator retaining screws. Figure “APPI lamp drive assembly” on page 4-5. See also: Remove the PEEK insulator from the mounting shaft. Use the O-ring removal kit to carefully remove the lamp bulb sealing O-ring from inside the end of the mounting shaft.
  • Page 59 Use the 2.5-mm Allen wrench to unscrew the four captive lamp mounting flange securing screws. Lamp mounting flange Captive securing screw (4-off) Remove the lamp mounting flange from the APPI source enclosure side plate. Use the O-ring removal kit to carefully remove the lamp mounting flange O-ring from the APPI source enclosure side plate.

  • Page 60: Fitting The New Appi Lamp Drive Assembly O-Rings

    The O-rings may be contaminated with Warning: biohazardous and/or toxic materials. Ensure that they are correctly disposed of according to local environmental regulations. 10. Dispose of the O-rings in accordance with local environmental regulations. Fitting the new APPI lamp drive assembly O-rings Required materials •...
  • Page 61 Fit the lamp mounting flange to the APPI source enclosure side plate. The securing screws must each be sequentially Caution: tightened a small amount until they are all fully tight; this ensures that the lamp mounting flange is uniformly seated on the APPI source enclosure side plate.
  • Page 62 To prevent damage to the mounting shaft O-rings, the Caution: mounting shaft insertion tool must be fitted to the mounting shaft before fitting the shaft to the lamp mounting flange. Insert the mounting shaft into the lamp mounting flange. Remove the mounting shaft insertion tool from the mounting shaft. Fit the lamp bulb sealing O-ring to the mounting shaft.
  • Page 63 To confirm the integrity of the source exhaust Warning: system, you must perform a pressure test on the source, as described in the Waters Source Pressure Test Unit Operator’s Guide. 23. Perform a pressure test on the source. Replacing the APPI lamp drive assembly O-rings...
  • Page 64 4-16 Maintenance Procedures...
  • Page 65 Safety Advisories Waters instruments display hazard symbols designed to alert you to the hidden dangers of operating and maintaining the instruments. Their corresponding user guides also include the hazard symbols, with accompanying text statements describing the hazards and telling you how to avoid them.

  • Page 66: A Safety Advisories

    Heed all warnings when you install, repair, and operate Waters instruments. Waters assumes no liability for the failure of those who install, repair, or operate its instruments to comply with any safety precaution.

  • Page 67: Warnings That Apply To Particular Instruments, Instrument Components, And Sample Types

    The following warnings can appear in the user manuals of particular instruments and on labels affixed to them or their component parts. Burst warning This warning applies to Waters instruments fitted with nonmetallic tubing. Pressurized nonmetallic, or polymer, tubing can burst. Warning: Observe these precautions when working around such tubing: •...
  • Page 68 Standby mode before touching areas marked with this high voltage warning symbol. Biohazard warning This warning applies to Waters instruments that can be used to process material that might contain biohazards: substances that contain biological agents capable of producing harmful effects in humans.

  • Page 69: Caution Symbol

    Chemical hazard warning This warning applies to Waters instruments that can process corrosive, toxic, flammable, or other types of hazardous material. Waters instruments can be used to analyze or Warning: process potentially hazardous substances. To avoid injury with any of these materials, familiarize yourself with the materials and their hazards, observe Good Laboratory Practices (GLP), and consult your organization’s safety...
  • Page 70 Attention: Changes or modifications to this unit not expressly approved by the party responsible for compliance could void the user’s authority to operate the equipment. Important: Toute modification sur cette unité n’ayant pas été expressément approuvée par l’autorité responsable de la conformité à la réglementation peut annuler le droit de l’utilisateur à...
  • Page 71 • Keine Schläuche verwenden, die stark geknickt oder überbeansprucht sind. • Nichtmetallische Schläuche nicht für Tetrahydrofuran (THF) oder konzentrierte Salpeter- oder Schwefelsäure verwenden. • Durch Methylenchlorid und Dimethylsulfoxid können nichtmetallische Schläuche quellen; dadurch wird der Berstdruck des Schlauches erheblich reduziert. Warnings that apply to all Waters instruments...
  • Page 72 Attenzione: prestare attenzione durante l’utilizzo dei tubi di polimero pressurizzati: • Indossare sempre occhiali da lavoro protettivi nei pressi di tubi di polimero pressurizzati. • Estinguere ogni fonte di ignizione circostante. • Non utilizzare tubi soggetti che hanno subito sollecitazioni eccessive o son stati incurvati.
  • Page 73 Warnings that apply to all Waters instruments...
  • Page 74 Warning: The user shall be made aware that if the equipment is used in a manner not specified by the manufacturer, the protection provided by the equipment may be impaired. Attention: L’utilisateur doit être informé que si le matériel est utilisé d’une façon non spécifiée par le fabricant, la protection assurée par le matériel risque d’être défectueuses.
  • Page 75 Attenzione: per una buona protezione contro i rischi di incendio, sostituire i fusibili con altri dello stesso tipo e amperaggio. Advertencia: sustituya los fusibles por otros del mismo tipo y características para evitar el riesgo de incendio. Warnings that apply to all Waters instruments A-11...
  • Page 76 Warning: To avoid possible electrical shock, disconnect the power cord before servicing the instrument. Attention: Afin d’éviter toute possibilité de commotion électrique, débranchez le cordon d’alimentation de la prise avant d’effectuer la maintenance de l’instrument. Vorsicht: Zur Vermeidung von Stromschlägen sollte das Gerät vor der Wartung vom Netz getrennt werden.

  • Page 77: Electrical And Handling Symbols

    Electrical and handling symbols Electrical symbols These can appear in instrument user manuals and on the instrument’s front or rear panels. Electrical power on Electrical power off Standby Direct current Alternating current Protective conductor terminal Frame, or chassis, terminal Fuse Recycle symbol: Do not dispose in municipal waste.

  • Page 78: Handling Symbols

    Handling symbols These handling symbols and their associated text can appear on labels affixed to the outer packaging of Waters instrument and component shipments. Keep upright! Keep dry! Fragile! Use no hooks! A-14 Safety Advisories...
  • Page 79 Materials of Construction and Compliant Solvents To confirm the integrity of the source exhaust Warning: system, you must address any safety issues raised by the contents of this Appendix. Topic Page Preventing contamination Items exposed to solvent Solvents used to prepare mobile phases...

  • Page 80: B Materials Of Construction And Compliant Solvents

    Preventing contamination For information on preventing contamination, refer to Controlling Contamination in LC/MS Systems (part number 715001307). You can find this document on http://www.waters.com; click Services and Support and then Support Center. Items exposed to solvent The items that appear in the following table can be exposed to solvent. You must evaluate the safety issues if the solvents used in your application differ from the solvents normally used with these items.

  • Page 81: Solvents Used To Prepare Mobile Phases

    Items exposed to solvent Item Material Probe adjuster assembly Anodized aluminium, glass filled acetal, and stainless steel Probe shaft PEEK Push-in gas fittings Nickel/brass Solvent waste/leak management Tygon tubing Source enclosure Alochromed aluminium Source enclosure view port Toughened plate glass Waste bottle Polypropylene Waste bottle push-in fittings...
  • Page 82 Materials of Construction and Compliant Solvents...

  • Page 83: Index

    Index removing compliant solvents Analyser tab connector APCI corona pin 3-14 APPI 4-14 APCI mode 3-10 4-15 obtaining an ion beam 3-12 construction materials preparing for operation in 3-10 contamination, preventing APCI probe corona pin APPI APCI 3-14 connector 4-14 dual APPI/APCI 3-11 3-15...
  • Page 84 in vitro diagnostic applications viii pin, corona installing combined APPI/APCI source APCI 3-14 dual APPI/APCI 3-11 3-15 instrument front panel connectors pressure test, performing APPI 4-14 preventing contamination 4-15 probe, APCI intended use viii pump ion beam, obtaining HPLC APCI mode 3-12 syringe APPI mode...
  • Page 85 warning syringe pump syringe type, selecting Tune window Analyser tab APPI Source tab UV lamp cleaning window replacing bulb turning on warning symbols Index-3...
  • Page 86 Index-4...

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