Requirements For The Components Of A Formulation; Specialties; Powder; Crystalline Active Substances - gako unguator EMP Quick Start Manual

Specialties

With the mixing parameters "Specialities" surface-active or sensitive active substances or force
sensitive foundations can be processed.
As an example, metronidazole, chlorhexidine gluconate, Linola
Therefore with suspension ointments < 2 % first use the "pre-grinding" parameters and for the
main mixing process the mixing parameters "specialties"
Jar size
Time (min.)
Stirrer Disp. Blade or SMB

Requirements for the Components of a Formulation

Powder

Generally, powders should be used as microfine and micronized substances.
In order to ensure better wetting of powders in aqueous compounds, micronized substances
should be added after any liquid components or covered with foundation.
For a solids content less than 2 %, we recommend applying the pre-grinding process together
with approx. 30 % of the ointment foundation (review pre-grinding).

Crystalline Active Substances

We recommend pulverizing active crystalline ingredients in a mortar prior adding into the jar to
avoid complex post processing (e.g. ointment mill). Should a solvent for the active crystalline
component be part of the formulation, the ingredient may then also be dissolved in the jar, for
example urea with water.
Then the remaining formulation component/s can be added. If the solvent is in sufficient
amounts a component of the ointment foundation the crystalline substance may dissolve
during the mixing process.
Level 4 (1200 rpm)
15 - 30 ml 50 - 100 ml
5:00 7:30
Disp. Blade or SMB
tab.: mixing parameter Specialties
.
®
200 ml 300 - 500 ml
12:55
Disp. Blade or SMB
chapter 4 - page 9
17:00
SMB