Troubleshooting Tips
No flow
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Undesired fragmentation
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Verify that the LC pump is on and there is sufficient solvent in the correct
bottle.
Verify that the solvent supply lines are free of air bubbles. Purge the
appropriate pump channels, if needed.
Check for LC error messages.
Check for blockages. Repair or replace any blocked components.
Check for leaks.
Verify that the MS stream selector valve is set to LC to MSD.
Fragmentor is set too high.
Ionization is causing fragmentation (APCI vs. Electrospray).
APCI temperature is too high.
Agilent 6100 Series LC/MS System Quick Start Guide