Nikon D300 User Manual page 131

▪ Excellent compatibility with the publishing industry.
▪ Is considered a lossless format since the image normally
uses no compression and loses no more data than the
initial camera conversion from 12 or 14 bits to 8 bits.
▪ Images can be modified and resaved an endless number
of times without losing image data.
▪ Does not require software post-processing during or after
download from the camera, so the image is immediately
usable.
TIFF Negatives
▪ The files are very large, so your ability to take a lot of
images requires large and expensive storage cards.
▪ Large computer hard drives are needed to store these
multi-megabyte images.
▪ In-camera image processing is slower, so you will be
limited in the number of fast pictures you can take.
Unless you have an extremely high-speed Internet connection,
don't even consider sending one of these monsters across the
Internet. Personally, I would rather shoot in
format since I can get almost double the number of images on
my memory card and they are 12 or 14 bits instead of the
TIFF mode's 8 bits.
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NEF (RAW)