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Qiagen QIAcube Connect User Manual

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December 2024
®
QIAcube
Connect User Manual
For use with software version 2.0
Sample to Insight

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Summary of Contents for Qiagen QIAcube Connect

  • Page 1 December 2024 ® QIAcube Connect User Manual For use with software version 2.0 Sample to Insight...

  • Page 2: Table Of Contents

    1. Introduction 1.1. About this user manual 1.2. General information 1.2.1. Technical assistance 1.2.2. Policy statement 1.3. Intended use of the QIAcube Connect 1.3.1. Limitations of use 1.3.2. Requirements for QIAcube Connect users 2. Safety Information 2.1. Proper use 2.2. Electrical safety 2.3.
  • Page 3 4.1.3. Grounding requirements 4.2. Unpacking the QIAcube Connect 4.3. Installing the QIAcube Connect 4.3.1. Removal of the QIAcube Connect accessories and shipping material 4.3.2. Installation of AC power cord 4.3.3. Installation of external barcode scanner 4.3.4. Installing the centrifuge rotor and buckets 4.3.5.
  • Page 4 5.12.3. Temporarily deactivating and reactivating a user 5.12.4. Resetting a user password 5.12.5. Changing password 6. Cleaning and Maintenance 6.1. Cleaning agents 6.2. Decontaminating the QIAcube Connect surface General instructions Removal of RNase contamination Removal of nucleic acid contamination 6.3. Regular maintenance 6.4.
  • Page 5 Schutz vor Stromschlag Umgebung Betriebsbedingungen Biologische Sicherheit Proben Chemikalien Giftige Dämpfe Abfallentsorgung Gefahren durch mechanische Teile Zentrifuge Gefahr durch Hitze Wartungssicherheit Strahlensicherheit Symbole auf dem QIAcube Connect Appendix E – QIAcube Connect Recycling Card Revision History QIAcube Connect User Manual  |  12/2024...

  • Page 6: Introduction

    Thank you for choosing the QIAcube Connect. We are confident it will become an integral part of your laboratory. Before using the QIAcube Connect, it is essential that you read this user manual carefully and pay attention to the safety information.

  • Page 7: General Information

    QIAGEN customers are a major source of information regarding advanced or specialized uses of our products. This information is helpful to other scientists as well as to the researchers at QIAGEN. We therefore encourage you to contact us if you have any suggestions about product performance or new applications and techniques.

  • Page 8: Intended Use Of The Qiacube Connect

    The system is intended for use by professional users trained in molecular biological techniques and the operation of the QIAcube Connect. The QIAcube Connect is intended to be used only in combination with QIAGEN kits indicated for use with the QIAcube Connect for the applications described in the kit handbooks.

  • Page 9: Safety Information

    2. Safety Information Before using the QIAcube Connect, it is essential that you read this user manual carefully and pay attention to the safety information. The instructions and safety information in the user manual must be followed to ensure safe operation of the instrument and to maintain the instrument in a safe condition.

  • Page 10: Electrical Safety

    In case of emergency, power OFF the QIAcube Connect at the power switch located in front of the instrument and unplug the power cord from the power outlet. CAUTION Damage to the instrument Only use QIAGEN spin columns and the QIAcube Connect-specific consumables with the QIAcube Connect.

  • Page 11: Environment

    It has been subjected to severe transport stresses. Liquids come in contact directly with electrical components of the QIAcube Connect. The power cord has been exchanged with a power cord that was not intended to be used with the QIAcube Connect. 2.3. Environment Parameters such as temperature range and humidity range are described in Technical Specifications.

  • Page 12: Operating Conditions

    The QIAcube Connect is not designed for use in an explosive atmosphere. CAUTION Damage to the instrument Direct sunlight may bleach parts of the instrument and cause damage to plastic parts. The QIAcube Connect must be located out of direct sunlight. CAUTION Damage to the instrument Do not use the QIAcube Connect in the vicinity of sources of strong electromagnetic radiation (e.g.,...

  • Page 13: Chemical Safety

    If working with volatile solvents or toxic substances, you must provide an efficient laboratory ventilation system to remove vapors that may be produced. WARNING Toxic fumes Do not use bleach to clean or disinfect the QIAcube Connect. Bleach in contact with salts from the buffers can produce toxic fumes. WARNING Toxic fumes Do not use bleach to disinfect used labware.

  • Page 14: Mechanical Hazards

    CAUTION Damage to the instrument The QIAcube Connect must not be used if the centrifuge lid is broken or if the lid lock is damaged. Make sure that no loose material is inside the centrifuge during operation. Make sure that the rotor is installed correctly and that all buckets are properly mounted, regardless of the number of samples to be processed.

  • Page 15: Heat Hazard

    Only perform maintenance that is specifically described in this user manual. WARNING Risk of explosion When cleaning the QIAcube Connect with alcohol-based disinfectant, leave the QIAcube Connect hood open to allow flammable vapors to disperse. Only clean the QIAcube Connect when worktable components have cooled down.

  • Page 16: Radiation Safety

    Damage to the instrument Do not use spray bottles containing alcohol or disinfectant to clean surfaces of the QIAcube Connect. Spray bottles should be used only to clean items that have been removed from the worktable and if permitted by local laboratory operating practices.

  • Page 17: Symbols On Theqiacube Connect

    Waste Electrical and Electronic Equipment (WEEE) mark for Europe Type plate on the back of the instrument Legal manufacturer At the back of the instrument Consult instructions for use Type plate on the back of the instrument See warnings and precautions QIAcube Connect User Manual  |  12/2024...
  • Page 18 Unique Device Identifier (UDI) as a 2D bar code in Data Matrix format Type plate on the back of the instrument Global Trade Item Number Type plate on the back of the instrument Serial number Type plate on the back of the instrument Catalog number QIAcube Connect User Manual  |  12/2024...

  • Page 19: General Description

    2. Each lysate is transferred to a spin column in a rotor adapter. If the lysate needs to be homogenized or cleared, it is first transferred to the middle position of the rotor adapter. 3. Nucleic acids or proteins bind to the silica membrane or purification resin of the QIAGEN spin column and are washed to remove contaminants.
  • Page 20 Exemplary procedure flowchart. QIAcube Connect User Manual  |  12/2024...

  • Page 21: External Features Of The Qiacube Connect

    3.2. External features of the QIAcube Connect Front view of the QIAcube Connect. Pulled-out touchscreen. Rear view of the QIAcube Connect. Rear view of the QIAcube Connect. Touchscreen 2 USB ports on the left side of the touchscreen; 2 USB ports behind the touchscreen...

  • Page 22: Touchscreen

    QIAcube Connect to local area network via cable. USB ports The QIAcube Connect has four USB ports (5). Two are located on the left of the touchscreen, and two are located behind the touchscreen. The USB ports located on the left of the touchscreen allow connection of the QIAcube Connect to a USB flash drive. Data files, such as support package, protocols, or report files, can be transferred via the USB port from the QIAcube Connect to QIAcube Connect User Manual  |  12/2024...

  • Page 23: Waste Drawer

    The USB ports located below the touchscreen allow insertion of a Wi-Fi adapter to enable Wi-Fi connection to a local network. Important: Use only the USB flash drive provided by QIAGEN. Do not connect other USB flash drive devices to USB ports. Insert only one USB stick for data transfer. Otherwise, no USB stick can be recognized.

  • Page 24: Power Cord Socket

    Field Service Specialist. Cooling air outlet Cooling air outlets are located at the rear left side of the QIAcube Connect and allow cooling of the internal components of the QIAcube Connect.

  • Page 25: External Barcode Scanner

    External barcode scanner The QIAcube Connect is equipped with a 2D handheld barcode scanner to allow kit barcode and sample bar code scanning. WARNING Risk of personal injury Hazard Level 2 laser light: Do not stare into the light beam when using handheld barcode scanner.

  • Page 26: Centrifuge

    WARNING Risk of personal injury and material damage To prevent plastic crash, load the tubes properly. After a plastic crash, sharp plastic particles could be inside the centrifuge. Be careful when handling items inside the centrifuge. QIAcube Connect User Manual  |  12/2024...

  • Page 27: Reagent Bottle Rack

    Reagent bottle rack The reagent bottle rack holds up to six 30 mL QIAcube Connect–specific reagent bottles and, for ease of use and high process safety, fits onto the QIAcube Connect worktable only in the correct orientation. Liquid is aspirated from the bottles by the pipetting system.

  • Page 28: Microcentrifuge Tube Slots

    Note: There is no liquid level detection on those slots. Ensure loading of the exact volume specified on the user interface. Tip rack slots Three tip racks can be placed on the QIAcube Connect worktable. Tips can be purchased in prefilled tip racks holding 200 µL filter-tips or 1000 µL filter tips, regular or wide-bore.

  • Page 29: Robotic Gripper

    Pipetting system The QIAcube Connect is equipped with a single-channel pipetting system that moves in the X, Y, and Z directions. The pipetting channel, fitted with a tip adapter, is connected to a precision syringe pump, which enables accurate transfer of liquids.

  • Page 30: Ultrasonic Sensor

    Run completed Error Aborted run Interior LED The QIAcube Connect is equipped with an interior LED that illuminates the worktable for ease of use. The LED can also indicate the instrument status (e.g., error) by blinking. QIAcube Connect User Manual  |  12/2024...

  • Page 31: Uv Led

    3.4. Disposables Rotor adapter A disposable rotor adapter holds a QIAGEN spin column and a microcentrifuge tube in a centrifuge bucket during sample processing. If required by the protocol, an additional column (e.g., QIAshredder column) can be placed in the middle position of the rotor adapter.

  • Page 32: Installation Procedures

    4.1. Installation environment 4.1.1. Site requirements The QIAcube Connect must be located out of direct sunlight, away from heat sources and away from sources of vibration and electrical interference. Refer to the Technical Specifications section for the operating conditions (temperature and humidity).

  • Page 33: Power Requirements

    Frequency  Pure sine wave  Waveform  Ensure that the voltage rating of the QIAcube Connect is compatible with the AC voltage available at the installation site. Mains supply voltage fluctuations are not to exceed 10% of nominal supply voltages. WARNING Damage to electronics Before powering ON the instrument, make sure that the correct supply voltage is used.

  • Page 34: Unpacking The Qiacube Connect

    1. Before unpacking the QIAcube Connect, move the package to the site of installation and check that the arrows on the package point upward. In addition, check whether the package is damaged. In case of damage, contact QIAGEN Technical Services.

  • Page 35: Installing The Qiacube Connect

    1. Remove the USB flash drive, rotor key, rotor nut, Allen key, S2 shaker adapter, and shaker rack plugs from the waste drawer. 2. Read the packing list to check that you have received all items. If anything is missing, contact QIAGEN Technical Services.

  • Page 36: Installation Of Ac Power Cord

    4.3.3. Installation of external barcode scanner 1. Remove the barcode scanner from the box. 2. Plug the USB connector of the scanner into one of the USB ports located on the left of the QIAcube Connect touchscreen. QIAcube Connect User Manual  |  12/2024...

  • Page 37: Installing The Centrifuge Rotor And Buckets

    2. Line up position 1 of the rotor with the pin on the rotor shaft and carefully lower the rotor onto the shaft. 3. Install the rotor nut on top of the rotor and tighten securely using the rotor key supplied with the QIAcube Connect. Make sure that the rotor is securely seated.

  • Page 38: Installing The Shaker Adapter

    The shaker adapter to be used is outlined by the loading instructions on the user interface (number in the overview picture and text below the picture: “use shaker type…”). The QIAcube Connect is delivered with the shaker adapter for 2 mL microcentrifuge safe-lock tubes already installed. If you need to install the shaker adapter for 2 mL screw-cap tubes, follow these steps: 1.

  • Page 39: Software Upgrade

    “QIAGEN software integrity verification process” description document, which is provided next to the software package on the QIAGEN webpage. The checksum provided on the download page is the checksum of the zip package. Ensure to perform the checksum comparison before unzipping.
  • Page 40 , download and transfer the software ZIP file to the main folder of the USB flash drive provided with the QIAcube Connect and extract the ZIP file there. Note: After extraction, make sure the following files are in the main folder of the USB flash drive: qcc1.sig...
  • Page 41 Up-to-date language packages are available for download on www.qiagen.com/QIAcube-Connect; see the Resources tab. Ensure that the language files are stored in a folder named “Language_Upload“ on the USB device.
  • Page 42 16. In case the automatic reboot does not take place in a timely manner, the instrument can also be rebooted using the Reboot button or by turning the instrument off and on again. 17. After a while without user action, the screen will change and directly instruct to remove the USB stick from the USB port. QIAcube Connect User Manual  |  12/2024...
  • Page 43 This happens automatically after the reboot and does not require any user interaction. It is outlined by the following screen: 20. If the firmware update has finished successfully, the login screen will be displayed. Wait until you see the login screen. QIAcube Connect User Manual  |  12/2024...

  • Page 44: Repackaging And Shipping Of The Qiacube Connect

    WARNING Risk of personal injury and material damage The QIAcube Connect is too heavy to be lifted by one person. To avoid personal injury or damage to the instrument, do not lift the instrument alone. Before transporting the QIAcube Connect, the instrument must first be decontaminated. Refer to Section 6.8, Decontaminating the QIAcube Connect, for more details.
  • Page 45 11. In the Run Modules menu, press the Centrifuge tab and then press Close Centrifuge Lid. 12. When the centrifuge lid is closed, power OFF the QIAcube Connect and open the hood. 13. Insert the foam protector into the front of the instrument.
  • Page 46 Shaker adapter 18. Place the handheld scanner into dedicated handheld scanner box. 19. Place the QIAcube Connect onto the pallet and put the black foam lid over the top of the instrument. Place the box onto the instrument. Important: When lifting the QIAcube Connect, slide your fingers under both sides of the instrument and keep your back straight.

  • Page 47: Configuration Of The Qiacube Connect

    4.5. Configuration of the QIAcube Connect When using the QIAcube Connect for the first time, it is recommended to define the required settings. Other settings can be made later when needed. For details on using the touchscreen and software, refer to Section  5.1 Use of the QIAcube Connect software.
  • Page 48 6. Initially, only one default user is available. In this case, enter “Admin” in both the user ID and password fields using the on-screen keyboard. Touch in the entry field to open the on-screen keyboard. 7. After the first login each user is asked to accept the end user license agreement. Press Accept. QIAcube Connect User Manual  |  12/2024...
  • Page 49 Change password screen. 9. For details on how to enter text or numbers, refer to Section  5.1 Use of the QIAcube Connect software. 10. Users with Administrator role are allowed to change or reset passwords for every other user including other administrators.

  • Page 50: System Configurations

    Current date and time System language These settings can only be made by users with Administrator role. When using the QIAcube Connect for the first time, it is recommended to set the current date and time. 1. On the menu bar, press the Configuration icon ( 2.
  • Page 51 Note: Do not rename or modify the language files or folder name. Otherwise, they cannot be used. d. Connect the USB flash drive to the QIAcube Connect using one of the USB ports at the left of the touchscreen. e. If not already done, select the Configuration icon ( f.
  • Page 52 Confirm by pressing Yes. 8. After successful upload the following message appears. Finish the process by pressing OK. QIAcube Connect User Manual  |  12/2024...

  • Page 53: Settings Configuration

    4.5.3. Network configuration and QIAsphere Base connection The QIAcube Connect can be connected to a network, allowing real-time status monitoring on a computer or a mobile device (e.g., a tablet) using the QIAsphere App; see www.qiagen.com/qiasphere. This configuration requires connecting the QIAcube Connect as well as the QIAsphere Base to your network.

  • Page 54: Using Qiasphere Communication On The Qiacube Connect

    Instrument requires maintenance. If your QIAsphere Base is connected to the QIAsphere Cloud, run reports generated by the QIAcube Connect (including sample IDs) are transferred to the QIAsphere Cloud. This transfer is encrypted. In case this transfer of information would still not be in accordance with your local regulations or with your laboratory regulations, the connection between the QIAsphere Base and the QIAsphere cloud needs to be actively deactivated.
  • Page 55 For communication with QIAsphere Base, the outbound TCP port 443 (https) is used; ping is supported. If QIAsphere connection is activated, the QIAcube Connect sends the following information to the QIAsphere Base and to the network:...

  • Page 56: Configuring A Wired Network Connection Of The Qiacube Connect

    Run status (running, finished successfully) Configuring a wired network connection of the QIAcube Connect 1. Connect the QIAcube Connect to a local area network (LAN) by using an Ethernet cable and the RJ45 ethernet port on the rear side of the QIAcube Connect.

  • Page 57: Configuring A Wireless Connection Of The Qiacube Connect

    Before Wi-Fi can be configured, the Wi-Fi USB device must be plugged into one of the USB ports behind the touchscreen. Important: Always turn off the QIAcube Connect before you plug in or unplug the Wi-Fi USB device. Plug-and-play of the Wi- Fi USB device while the instrument is turned on is not supported.

  • Page 58: Connecting The Qiacube Connect To The Qiasphere Base

    Follow first the instructions of the QIAsphere User Manual (www.qiagen.com/qiasphere) to connect the QIAsphere Base to the same local network as the QIAcube Connect is connected to. During this procedure, the QIAsphere Base receives an IP address which is required in the following configuration: 1.
  • Page 59 5. Your QIAcube Connect is now connected to the QIAsphere Base, and you can proceed with setting up QIAsphere according to the QIAsphere User Manual. QIAsphere screen for connection with QIAcube Connect. Note: To disable QIAsphere Base connection, uncheck Enable QIAsphere communication box.

  • Page 60: Operating Procedures

    Connect. Damage caused by use of other types of spin columns or chemistries will void your warranty. The hood of the QIAcube Connect must remain closed during operation of the instrument. Only open the hood when instructed to do so by the software.
  • Page 61 WARNING Risk of fire or explosion When using ethanol or ethanol-based liquids on the QIAcube Connect, handle such liquids carefully and in accordance with the required safety regulations. If liquid has been spilled, wipe it off and leave the QIAcube Connect hood open to allow flammable vapors to disperse.

  • Page 62: Use Of The Qiacube Connect Software

    Only perform maintenance that is specifically described in this user manual. 5.1. Use of the QIAcube Connect software The QIAcube Connect is operated through a touchscreen, which guides you step-by-step through the correct loading of the work deck and selection of the protocol.
  • Page 63 QIAsphere connection is disabled. Log out from the instrument To enter text or numbers, touch the respective field. The corresponding on-screen keyboard will be displayed. Keyboard for entering a sample name. Keyboard for editing a protocol parameter. QIAcube Connect User Manual  |  12/2024...
  • Page 64 Switch to upper-case letters. Allows to type a number of upper-case letters. Press the symbol again to return to lower-case letters. Show special characters. Return to letters. Navigate through the text in the input field. Confirm and close. Discard and close. QIAcube Connect User Manual  |  12/2024...

  • Page 65: Switching The Qiacube Connect On And Off

    Note: After powering OFF the QIAcube Connect, you must wait for a few seconds before you power ON the instrument again. The system might fail to start if you do not allow the QIAcube Connect to rest for a few seconds before powering ON.

  • Page 66: Logging Out

    In the case that another user logs in, the configuration settings from the previous user will be applied. 5.4. Setting up a protocol run All released QIAGEN standard protocols are installed on the QIAcube Connect upon delivery. Available QIAGEN protocols can also be downloaded from the Resources tab of the QIAcube Connect product page: www.qiagen.com/QIAcube-...
  • Page 67 1. Prepare the samples to be processed using the protocol indicated in the protocol selection screen. Refer to the kit handbook for more information, if required. 2. To start the run setup, select from Applications or Favorites, or scan the 2D barcode of the QIAGEN kit with the handheld scanner.

  • Page 68: Kit Selection

    2. Press Next to proceed to defining the sample material. 5.4.2. Material selection Select material screen. 1. Select the sample material by touching the corresponding row. Only one sample material type can be selected per run. 2. Press Next to proceed to define the protocol. QIAcube Connect User Manual  |  12/2024...

  • Page 69: Protocol Selection

    These parameters are fixed as they are validated for the procedure. For protocols with editable parameters, default settings are defined but can be changed. Follow the instructions in the information pane on the right regarding changing the values and which increments can be used. Define parameters screen. QIAcube Connect User Manual  |  12/2024...

  • Page 70: Sample Number Definition

    1. To select the number of samples for the run, press the corresponding number on the screen. Sample numbers that would lead to a misbalance during centrifugation cannot be chosen. 2. Press Next to proceed to loading the reagents. 5.4.6. Loading buffer bottles Load buffer bottles screen. QIAcube Connect User Manual  |  12/2024...
  • Page 71 Before proceeding to the next step, ensure that you read all essential and critical information indicated in the Information icon ( ) marked in red. Press the icon to open the information. Example of message box displayed by hitting the Information icon ( QIAcube Connect User Manual  |  12/2024...
  • Page 72 For subsequent runs, fresh buffer should be refilled. We recommend reusing the buffer bottles only until one kit is used up. As soon as a new QIAGEN kit is opened, new buffer bottles should be used.

  • Page 73: Loading Tips And Enzymes

    Before proceeding to the next step, make sure that you read all essential and critical information indicated in the Information icon ( ) marked in red. 2. Make sure that you are using the correct tube type. Press the Information icon ( ) in the respective row to show the details. QIAcube Connect User Manual  |  12/2024...

  • Page 74: Loading The Centrifuge

    There are 3 different kinds of tip racks that can be used on the QIAcube Connect, depending on the protocol selected. A blue rack for 200 µL filter-tips, a light gray rack for 1000 µL filter-tips and a dark gray rack for 1000 µL wide-bore filter- tips.
  • Page 75 (compare with part A of the above figure); Incorrectly loaded rotor adapter seen from the side (compare with part B of the above figure). QIAcube Connect User Manual  |  12/2024...
  • Page 76 Depending on the selected protocol, samples can be loaded onto the shaker or directly into the centrifuge. Follow the instructions below the screenshot corresponding to your screen. Your screen may look different depending on the selected protocol. QIAcube Connect User Manual  |  12/2024...

  • Page 77: Loading The Centrifuge In Case Samples Are Loaded Onto Shaker

    7. Press Next to proceed with loading the samples into the shaker. Follow the instructions in Section 5.4.9 Loading the shaker. Depending on the selected protocol, the sequence of the next screens can be different. 8. If samples are loaded into the shaker, the next section can be skipped. QIAcube Connect User Manual  |  12/2024...

  • Page 78: Loading Samples Into The Centrifuge

    6. Press Next to proceed loading of rotor adapters into centrifuge. Load the rotor adapters into centrifuge. Place the prepared rotor adapters into the centrifuge buckets as shown on the right side of screen. For ease of use and safety, the QIAcube Connect User Manual  |  12/2024...
  • Page 79 Note: Sample IDs are part of the run reports. These IDs are not encrypted. Important: Please note that the sample ID field must not contain any personal data. 8. Press Next to proceed to start the run. QIAcube Connect User Manual  |  12/2024...

  • Page 80: Loading The Shaker

    4. Load the tubes into the correct position of the shaker rack. Touch the table row to highlight the position in the schematic at the right. The shaker rack positions are numbered for easy identification. Touch the table row to highlight the position in the schematic at the right. QIAcube Connect User Manual  |  12/2024...
  • Page 81 The pictures below indicate how the shaker loading illustrated on the user interface (left-hand side) translates into the real shaker layout (right-hand side). Lids of sample tubes must be securely placed into the slots at the edge of Loading the shaker rack with sample tubes that have attached lids. the shaker rack. QIAcube Connect User Manual  |  12/2024...

  • Page 82: Starting A Protocol Run

    This will allow you to add missing reagents or consumables in case the instrument detects missing items. The status of the load check and the recommendation to wait until it is finished is also shown on the user interface. QIAcube Connect User Manual  |  12/2024...
  • Page 83 Note: For the very first run of a certain application and sample number, the estimated run duration is not available. If the same application has been used before (with the same amount of samples), a run time estimation is available. Run status screen during a protocol run. QIAcube Connect User Manual  |  12/2024...
  • Page 84 5. Press Done to create the report file. The run report is a PDF file and contains the following information: the protocol information (name and the version of the completed application process file) the serial number of the instrument the software version the sample IDs and their positions QIAcube Connect User Manual  |  12/2024...

  • Page 85: Stopping A Protocol Run

    If a run is stopped, perform the daily maintenance as described in Section 6.4 Daily maintenance, and ensure that no plastic parts are present in the centrifuge before starting the next run. Additionally, it is recommended to reboot the system before starting the next run. QIAcube Connect User Manual  |  12/2024...

  • Page 86: Adding Protocols To Favorites

    Upload button (for details, see Section 5.8.2). 4. If not yet connected, connect the USB flash drive, which is delivered with the instrument, to one of the USB ports at the left of the touchscreen. QIAcube Connect User Manual  |  12/2024...

  • Page 87: Low Space On Flash Memory

    1. Connect the USB flash drive, which is delivered with the instrument, to one of the USB ports at the left of the touchscreen. 2. Press Download files button. Note: As soon as Download files button has been pressed, the Check done button is enabled. 3. Check downloaded files on USB stick, and press Check done button. QIAcube Connect User Manual  |  12/2024...
  • Page 88 If the free disk space is close to 7400 KB, you should free disk space by deleting files under the Data Exchange tab by clicking the Tools icon. Free disk space information. QIAcube Connect User Manual  |  12/2024...

  • Page 89: Upload Custom Logo To Run Report

    5.8.2. Upload custom logo to run report Next to the QIAGEN logo on the top left corner of the run report, a second logo can be uploaded to the run report that will be displayed on the top right corner of the run report.

  • Page 90: Remove Custom Logo From Run Report

    5.8.3. Remove custom logo from run report To remove a custom logo, select Data Exchange tab without inserted USBstick. Instead of Upload button, this button will show Remove. Click Remove and confirm removal of custom logo. Remove custom logo from run report. QIAcube Connect User Manual  |  12/2024...

  • Page 91: Independent Heater/Shaker Operation

    5.9. Independent heater/shaker operation The heater/shaker can be operated individually if the QIAcube Connect is not running a protocol. The heating and shaking functions are not interlinked and can be used independently or in combination. WARNING Risk of personal injury and material damage Do not attempt to move the QIAcube Connect during operation.

  • Page 92: Independent Centrifuge Operation

    CAUTION Damage to the instrument The QIAcube Connect must not be used if the centrifuge lid is broken, or if the lid lock is damaged. Make sure that no loose material is inside the centrifuge during operation. Make sure that the rotor is installed correctly and that all buckets are properly mounted, regardless of the number of samples to be processed.
  • Page 93 5. If the centrifuge lid is not open, press Open Centrifuge Lid. 6. If required, load opened 1.5 mL microcentrifuge elution tubes and/or QIAGEN spin columns into the rotor adapters and place the lids into the appropriate slots in the rotor adapter.
  • Page 94 Centrifuge loading scheme No. of samples Centrifuge loading scheme No. of samples Centrifuge loading scheme Load all positions QIAcube Connect User Manual  |  12/2024...

  • Page 95: Managing Protocols

    Note: Do not rename or modify the protocol files. Otherwise, they cannot be used. 4. Connect the USB flash drive to the QIAcube Connect using one of the USB ports at the left of the touchscreen. 5. Select the Configuration icon ( ).
  • Page 96 All compatible protocol zip file(s) in the “Protocol_Upload” folder will be installed. 10. During transfer the progress is visualized by a moving bar. 11. Wait until the transfer is complete. A message is displayed when the transfer is complete. QIAcube Connect User Manual  |  12/2024...
  • Page 97 13. If problems occur during update, a corresponding message will be displayed to the user, stating the abort and the reason. If the USB contains only invalid protocols, the following message box appears, and the update procedure will not be performed. If there are no protocol files on the USB, the corresponding message box appears. QIAcube Connect User Manual  |  12/2024...

  • Page 98: Installing Protocols Via Qiasphere

    QIAsphere button and is highlighted by a red dot. 1. Press the Info button ( ) . 2. The available protocol package is described in the message box. If you wish to download the specified protocol package press Download. QIAcube Connect User Manual  |  12/2024...
  • Page 99 3. The following dialog appears. Confirm the protocol download with OK. 4. After successful download a red dot on the QIAsphere icon will indicate a new notification. 5. Check the QIAsphere notifications, and press the Info button ( ) again. QIAcube Connect User Manual  |  12/2024...
  • Page 100 8. If duplicate or incompatible protocols have been detected, the user will see the message box with the information about which protocols cannot be installed. All other protocols from the package will be installed on the instrument. QIAcube Connect User Manual  |  12/2024...
  • Page 101 9. The progress of the installation will be shown by a moving bar in the QIAsphere Notification Center. 10. After successful installation, a message box with a summary of installed, removed, or overwritten protocols appears. QIAcube Connect User Manual  |  12/2024...

  • Page 102: Deleting Protocols

    3. To delete all protocols installed on the instrument, press Delete All. To delete single protocols, press Delete selected. 4. Click + to extend the list of protocol folder. Deleting selected protocols. 5. Click + to extend the list of protocols. QIAcube Connect User Manual  |  12/2024...
  • Page 103 6. Select single or multiple protocol(s) and click Delete to remove them at once. Note: Deletion of parent folder is not possible. Deletion of selected protocols. 7. A message box with a summary of the deletion appears. Confirm by pressing Yes if you wish to proceed. QIAcube Connect User Manual  |  12/2024...

  • Page 104: Saving Protocols

    Use the USB flash drive provided by QIAGEN. 1. Connect the USB flash drive that was shipped together with the instrument to the QIAcube Connect using one of the USB ports at the left of the touchscreen.

  • Page 105: User Management

    5.12. User management The QIAcube Connect is provided with a User Management feature. This feature enables you to set up multiple users with two different roles: administrator and operator. When you use the QIAcube Connect for the first time, a default user named Admin is already pre-installed and configured with both roles assigned.
  • Page 106 Important: A newly created user with administrator rights can only configure the system and cannot start a run. If this is required both roles have to be chosen. 5. Press OK to save the new user. QIAcube Connect User Manual  |  12/2024...

  • Page 107: Changing Data For An Existing User

    If you touch the password field, the existing password will be cleared, and a new password must be entered and confirmed. 6. To confirm the changes, press OK. To close the dialog and discard the changes, press Cancel. QIAcube Connect User Manual  |  12/2024...

  • Page 108: Temporarily Deactivating And Reactivating A User

    ) in the user profile row. Uncheck the Activate User box. It is not possible to deactivate the currently logged-in administrator. 2. To reactivate a user profile, deactivated users can be displayed in the users list by unchecking the box “Show only activated user profiles”. QIAcube Connect User Manual  |  12/2024...

  • Page 109: Resetting A User Password

    If no alternative user with administrator role is available, open the Help Center (Help button at upper right-hand side) and follow the screen instructions. Only an administrator user password can be reset. Login screen with Help button. QIAcube Connect User Manual  |  12/2024...

  • Page 110: Changing Password

    Note your instrument serial number and the challenge code generated in the Help Center and contact QIAGEN Technical Services. Ensure you have an email address available which is already known to QIAGEN Technical Services. You will receive a one-time password.

  • Page 111: Cleaning And Maintenance

    Monthly maintenance: every month Periodic maintenance: when necessary; at least every 6 months Optionally, these procedures may be performed to check and ensure the reliability of operation of the QIAcube Connect: UV Run: reduces contaminants (e.g., nucleic acid and E. coli) Tightness Test: ensures the tightness of the tip adapter (e.g., after O-Ring change)

  • Page 112: Cleaning Agents

    If solvents or saline, acidic, or alkaline solutions are spilt on the QIAcube Connect or if QIAGEN buffers splash the instrument hood, wipe the spilt liquid away immediately.

  • Page 113: Removal Of Rnase Contamination

    Damage to the instrument Do not use spray bottles containing alcohol or disinfectant to clean surfaces of the QIAcube Connect. Spray bottles should be used only to clean items that have been removed from the worktable and if permitted by local laboratory operating practices.

  • Page 114: Regular Maintenance

    QIAcube Connect hood open to allow flammable vapors to disperse. WARNING Toxic fumes Do not use bleach to clean or disinfect the QIAcube Connect or the labware, as bleach in contact with salts from the buffers can produce toxic fumes. 6.3. Regular maintenance After running a protocol, perform the regular maintenance procedure described below.

  • Page 115: Daily Maintenance

    5. Close the buffer bottles tightly and store according to the instructions in the relevant kit handbook. We recommend reusing the buffer bottles only until the kit is used up. As soon as a new QIAGEN kit is opened, new buffer bottles should be used.

  • Page 116: Monthly Maintenance

    5. Thoroughly clean the worktable with alcohol-based disinfection wipes. Incubate as appropriate, rinse thoroughly with distilled water and wipe dry with paper towels. Important: Do not use alcohol or alcohol-based disinfectants to decontaminate the QIAcube Connect hood. 6. Clean the touchscreen with alcohol-based disinfection wipes and wipe dry afterwards.

  • Page 117: Periodic Maintenance

    10. Press Done only when the steps listed above have been successfully completed. The date of the last performed monthly maintenance is updated automatically. Important: Inspect the waste drawer during maintenance. Contact QIAGEN Technical Services if any broken parts are observed.

  • Page 118: Cleaning The Centrifuge

    Last Executed centrifuge maintenance date and a cycle count. Centrifuge maintenance screen. 2. Press Start to begin the centrifuge cleaning procedure. Follow the instructions on the screen. Details are provided in the next steps below. QIAcube Connect User Manual  |  12/2024...
  • Page 119 5. When cleaning is completed, turn on the instrument and log in. Press the Tools icon ( ) and then the Maintenance tab. Select the Centrifuge subtab. 6. Press Start again then press Done to confirm cleaning. The date of the last performed cleaning of centrifuge is updated automatically. QIAcube Connect User Manual  |  12/2024...

  • Page 120: Cleaning The Rotor And Buckets

    Cleaning the rotor and buckets Note: Ensure that the instrument is switched off during cleaning. 1. Make sure the QIAcube Connect is switched off. 2. Remove all disposable rotor adapters, including tubes and spin columns, from the buckets. 3. Remove the buckets from the rotor. Undo the rotor nut on top of the rotor using the rotor key, and carefully lift the rotor off the rotor shaft.

  • Page 121: Cleaning The Centrifuge

    3. Clean the centrifuge lid with a soft lint-free cloth moistened with cleaning agent. Incubate as appropriate, clean with water and wipe dry with lint--free paper towels. 4. Check the centrifuge gasket for damage. If the gasket is damaged or shows signs of wear, contact QIAGEN Technical Services.

  • Page 122: Maintenance Of The Rotor Nut

    After cleaning the inner thread of the rotor nut, wipe the thread using Anti-Corrosion Oil as described above. Note: Contact QIAGEN Technical support if the pin on the rotor thread fell out. Do not reinsert the pin! Do not run the centrifuge! QIAcube Connect User Manual  |  12/2024...

  • Page 123: Installing The Centrifuge Rotor And Buckets

    Note: If the pin is loose or falls out, call QIAGEN Technical Services. 3. Install the rotor nut on top of the rotor and tighten securely using the rotor key supplied with the QIAcube Connect. Make sure that the rotor is securely seated.

  • Page 124: Operating The Centrifuge After Cleaning

    Note: The Open centrifuge lid and Close centrifuge lid buttons are not needed to start a centrifuge run, as the lid will close automatically. Instead, they are needed in case you need to prepare the QIAcube Connect for shipment or during troubleshooting.

  • Page 125: Optional Maintenance

    The UV run is recommended to be performed daily for decontamination purposes. It helps to reduce possible contaminants (e.g., nucleic acids and E. coli) of the QIAcube Connect worktables. The efficiency of inactivation depends, for example, on layer thickness and sample type. QIAGEN cannot guarantee complete eradication of specific contaminants.

  • Page 126: Tightness Test

    8. Wait until the test has been completed and then press Next. 9. Open the QIAcube Connect hood and remove the buffer bottle and tips to store them accordingly. 10. Remove the tube and visually check if liquid is present:...

  • Page 127: Decontaminating The Qiacube Connect

    12. Press Done to finalize tightness test procedure. The date of the last performed tightness test is updated automatically. 6.8. Decontaminating the QIAcube Connect If the QIAcube Connect is contaminated with infectious material, it should be decontaminated. If hazardous material is spilt on or inside the QIAcube Connect, the user has responsibility for carrying out appropriate decontamination.

  • Page 128: Troubleshooting

    7. Troubleshooting This section provides information about what to do if an error occurs when using the QIAcube Connect. If further assistance is required, contact QIAGEN Technical Services using the contact information below: Website: support.qiagen.com When contacting QIAGEN Technical Services about an error with the QIAcube Connect, note the steps leading to the error and any information appearing in any dialog boxes.

  • Page 129: Creating A Support Package

    7.1. Creating a support package The support package is a zip file that can be sent to QIAGEN Technical Services for diagnosis and trouble shooting. 1. On the menu bar, press the Tools icon ( 2. Press the Data Exchange tab.

  • Page 130: Operation

    Display does not turn on Contact QIAGEN Technical Services for repair. Power OFF the QIAcube Connect, wait for a few minutes, and power it ON again. Save the file(s) to the USB Error when copying files to USB flash drive again. Check the USB flash drive on a PC to ensure it is functional. If the error persists, contact QIAGEN Technical Services.

  • Page 131: Protocol Interruption

    If the touchscreen does not display the login screen, but instead a software update message is shown, power Login screen not visible when launching OFF the QIAcube Connect, wait for a few minutes. Ensure that the USB flash drive is not inserted in the USB instrument port.
  • Page 132 8. Manually raise the centrifuge lid. 9. Hold the raised lid and remove the samples and rotor adapters from the rotor. Removing rotor adapters. Contact QIAGEN Technical Services for instructions on how to reset the lid. QIAcube Connect User Manual  |  12/2024...

  • Page 133: Liquid Spills In The Centrifuge

    Liquid spills in the centrifuge The rotor adapter is designed for use with QIAGEN automated protocols. Do not fill the rotor adapters with liquid. Liquid spills may occur if QIAGEN spin columns become blocked due to sample overloading. Do not exceed the maximum amount of starting material.

  • Page 134: Touchscreen

    1. Turn OFF the QIAcube Connect. 2. Wait a few minutes and then turn ON the instrument again. 3. In the second screen press the QIAGEN logo. Note: If you do not press the logo, the instrument will continue initialization.
  • Page 135 4. Press Calibrate Touch Screen. Initial screen for the touchscreen calibration. 5. An information message is displayed. The message will close automatically after 10 seconds if you are unable to close it by pressing OK. QIAcube Connect User Manual  |  12/2024...
  • Page 136 8. Plus signs (+) will be shown at different positions on the screen. For each of these, press the center of the + sign. After one position is touched, the next position will be shown. The graphic below shows the positions and the order in which the + signs will appear. Screen for touchscreen calibration. QIAcube Connect User Manual  |  12/2024...

  • Page 137: O-Ring Exchange

    Uneven volume transfers Dripping on the worktable In any case, it is recommended to consult QIAGEN technical service. The replacement procedure requires the O-Ring change tool and an O-Ring. See Appendix B – QIAcube Connect Accessories for ordering details. O-Ring tool with prepared new O-Ring.
  • Page 138 3. To prepare the O-Ring tool, perform the following steps: a. Slide the new O-Ring over the small end of the peg. b. Push the gray lever until you reach the black stop, and insert the small end of the peg into the hole. QIAcube Connect User Manual  |  12/2024...
  • Page 139 Open the gray lever and insert the peg with small end first into hole as shown. 4. Press Next on the screen and begin loading of the O-Ring tool into the QIAcube Connect. 5. Load the O-Ring tool by opening the gray lever into tip rack position 1 (nearest to user).
  • Page 140 9. Open the hood and visually check if new O-Ring sits firmly on tip adapter. Check if the new O-Ring sits firmly. Note: If the O-Ring was not successfully picked up, complete the O-Ring replacement procedure and restart. QIAcube Connect User Manual  |  12/2024...
  • Page 141 Risk of personal injury and material damage CAUTION Improper use of the QIAcube Connect may cause personal injuries or damage to the instrument. The QIAcube Connect must only be operated by qualified personnel who have been appropriately trained. Servicing of the QIAcube Connect must only be performed by a QIAGEN field service specialist.

  • Page 142: Technical Specifications

    8. Technical Specifications QIAGEN reserves the right to change specifications at any time. 8.1. Operating conditions Description Requirement 100–240 V AC, 50/60 Hz, 650 VA Mains supply voltage fluctuations are not to exceed 10% of nominal Power supply voltages. Note: The apparent power can exceed 650 VA for up to 2 seconds during the centrifuge acceleration and can reach an approximate value of 1200 VA.

  • Page 143: Mechanical Data And Hardware Features

    Motion Tolerance: Up to 610 cm/s (240 in/s) for 13 mil UPC at optimal focus Symbol Contrast: 20% minimum reflectance difference Decode Capability: Reads standard 1D, PDF, 2D, Postal, and OCR symbologies QIAGEN protocols are preinstalled on the QIAcube Connect or can be downloaded at www.qiagen.com Software...

  • Page 144: Glossary

    A 3- or 4-digit number that indicates an error of the QIAcube Connect. Filter-tip An item of labware that is picked up by the tip adapter during operation of the QIAcube Connect. Liquid is aspirated into and dispensed from a filter-tip.

  • Page 145: Appendix A - Legal

    Recycling can be provided by QIAGEN upon request at additional cost. In the European Union, in accordance with the specific WEEE recycling requirements and where a replacement product is being supplied by QIAGEN, free recycling of its WEEE-marked electronic equipment is provided.

  • Page 146: Fcc Declaration

    QIAGEN GmbH Germany is not responsible for any radio television interference caused by unauthorized modifications of this equipment or the substitution or attachment of connection cables and equipment other than those specified by QIAGEN GmbH, Germany. The correction of interference caused by such unauthorized modification, substitution or attachment will be the responsibility of the user.

  • Page 147: Liability Clause

    QIAGEN. The QIAcube Connect is equipped with an Ethernet port and a Wi- Fi USB device. The Purchaser of the QIAcube Connect is solely responsible for preventing any and all computer viruses, worms, trojans, malware, hacks, or any other type of cybersecurity breaches.

  • Page 148: Appendix B - Qiacube Connect Accessories

    Set of 10 O-Rings for use with the QIAcube Connect 9018472 * All configurations include: QIAcube Connect robotic workstation for automated purification of DNA, RNA, or proteins using QIAGEN spin-column kits and QIAspere Base to connect to local network, bar code reader and 1-year warranty on parts and labor.

  • Page 149: Appendix C - Consignes De Sécurité

    Appendix C – Consignes de Sécurité Avant d’utiliser le QIAcube Connect, il est impératif de lire attentivement ce manuel d’utilisation et de faire attention aux informations de sécurité. Pour garantir un fonctionnement de l’appareil en toute sécurité et le maintenir en bon état de marche, il est impératif de suivre les instructions et les informations de sécurité...
  • Page 150 Éviter de renverser de l’eau ou des produits chimiques sur le QIAcube Connect. La détérioration due à la projection d’eau ou de produits chimiques annulera la garantie. En cas d’urgence, éteindre le QIAcube Connect à l’aide de l’interrupteur d’alimentation situé à l’avant de l’instrument et débrancher le cordon d’alimentation de la prise de courant.

  • Page 151: Sécurité Électrique

    Toute autre maintenance ou réparation ne peut être effectuée que par un spécialiste de l’entretien sur site. Suivre ces instructions afin que le QIAcube Connect fonctionne de manière satisfaisante et en toute sécurité : Le cordon d’alimentation doit être branché à une prise de courant disposant d’un conducteur de protection (terre/masse).

  • Page 152: Environnement

    Détérioration de l’instrument L’exposition à la lumière solaire directe peut provoquer le blanchiment de certains éléments de l’appareil et détériorer les pièces en plastique. Le QIAcube Connect doit être tenu à l’abri de la lumière directe du soleil. ATTENTION Détérioration de l’instrument Ne pas utiliser le QIAcube Connect à...

  • Page 153: Sécurité Biologique

    * OSHA — Occupational Safety and Health Organization (United States of America) † ACGIH – American Conference of Government Industrial Hygienists (United States of America) ‡ COSHH – Control of Substances Hazardous to Health (United Kingdom) QIAcube Connect User Manual  |  12/2024...

  • Page 154: Vapeurs Toxiques

    Mise au rebut des déchets Tout matériel de laboratoire qui a été utilisé, tel que les tubes d’échantillons, colonnes de centrifugation QIAGEN, embouts à filtre, flacons de tampon, tubes d’enzymes ou adaptateurs pour rotor, peut contenir des produits chimiques ou des agents infectieux dangereux issus de la purification.

  • Page 155: Centrifugeuse

    ATTENTION Détérioration de l’instrument Le QIAcube Connect ne doit pas être utilisé si le couvercle de la centrifugeuse est cassé ou si le verrou du couvercle est endommagé. Veiller à ce qu’aucune pièce libre ne se trouve à l’intérieur de la centrifugeuse en cours de fonctionnement.

  • Page 156: Dangers Liés À La Chaleur

    Afin de garantir une bonne ventilation, laisser un dégagement d’au moins 10 cm sur les côtés et à l’arrière du QIAcube Connect. Les fentes et les ouvertures qui assurent la ventilation du QIAcube Connect ne doivent pas être obstruées. Dangers liés à la chaleur La table de travail du QIAcube Connect contient un agitateur chauffé.

  • Page 157: Sécurité Contre Les Rayonnements

    Ne pas utiliser de flacons pulvérisateurs contenant de l’alcool ou un agent désinfectant pour nettoyer les surfaces du QIAcube Connect. Les flacons pulvérisateurs ne doivent être utilisés que pour nettoyer les éléments qui ont été retirés des tables de travail et si les pratiques opérationnelles du laboratoire local le permettent.

  • Page 158: Symboles Sur Le Qiacube Connect

    Symboles sur le QIAcube Connect Symbole Location Description À proximité de l’agitateur Danger lié à la chaleur – la température de l’agitateur peut monter jusqu’à 70 °C. À proximité de la centrifugeuse ; à Dangers mécaniques — éviter tout contact avec les pièces en mouvement.
  • Page 159 UDI (Unique Device Identifier) en tant que code-barres 2D au format Data Matrix l’instrument Plaque signalétique à l’arrière de Code article international (Global Trade Item Number, GTIN) l’appareil Plaque signalétique à l’arrière de Numéro de série l’instrument Plaque signalétique à l’arrière de Numéro de référence l’instrument QIAcube Connect User Manual  |  12/2024...

  • Page 160: Appendix D - Sicherheitshinweise

    Reparaturen, die auf nicht fachgerecht durchgeführte Wartungsmaßnahmen zurückzuführen sind, in Rechnung. WARNUNG Gefahr von Personen- und Sachschäden Der QIAcube Connect aufbauen ist sehr schwer und sollte nicht von nur einer Person angehoben werden. Heben Sie das Gerät nicht allein an, um eine Verletzung und/oder Beschädigung des Geräts zu vermeiden.
  • Page 161 Verschütten Sie kein Wasser und keine Chemikalien auf dem QIAcube Connect. Durch verschüttetes Wasser oder verschüttete Chemikalien verursachte Schäden führen zum Erlöschen der Garantie. Schalten Sie den QIAcube Connect im Notfall am Netzschalter an der Front des Geräts AUS und ziehen Sie das Netzkabel aus der Netzsteckdose.

  • Page 162: Schutz Vor Stromschlag

    Falls Gefahrstoffe auf dem oder im QIAcube Connect verschüttet werden, ist der Benutzer für die Durchführung einer entsprechenden Dekontamination verantwortlich. Hinweis: Stellen Sie keine Gegenstände oben auf der Gerätehaube des QIAcube Connect ab. VORSICHT Beschädigung des Geräts Lehnen Sie sich nicht an den Touchscreen, wenn er herausgezogen ist.

  • Page 163: Umgebung

    Gerät für längere Zeit unter ungünstigen Bedingungen gelagert wurde; das Gerät unsachgemäß transportiert worden ist. flüssigkeiten in direkten Kontakt mit elektrischen Komponenten des QIAcube Connect gekommen sind. das Netzkabel wurde gegen ein Netzkabel ausgetauscht, das nicht für die Verwendung mit dem QIAcube Connect vorgesehen ist. Umgebung Parameter wie Temperatur- und Feuchtigkeitsbereich sind in den Technischen Daten beschrieben.

  • Page 164: Biologische Sicherheit

    VORSICHT Beschädigung des Geräts Der QIAcube Connect darf nicht in der unmittelbaren Nähe von Quellen starker elektromagnetischer Strahlung (z. B. nicht abgeschirmten, absichtlich betriebenen HF-Quellen oder Mobilfunkgeräten) aufgestellt oder betrieben werden, da diese den ordnungsgemäßen Betrieb des Geräts stören können.

  • Page 165: Chemikalien

    Dämpfe abziehen können. WARNUNG Giftige Dämpfe Verwenden Sie keine Bleichmittel zum Reinigen oder Desinfizieren des QIAcube Connect. Bleichmittel können mit Salzen, die in den Puffern enthalten sind, reagieren und giftige Dämpfe erzeugen. WARNUNG Giftige Dämpfe Verwenden Sie zum Desinfizieren von gebrauchten Verbrauchsmaterialien keine Bleichmittel.

  • Page 166: Abfallentsorgung

    Bitte beachten Sie bei der Entsorgung die geltenden Sicherheitsbestimmungen. Gefahren durch mechanische Teile Die Gerätehaube des QIAcube Connect muss während des Betriebs geschlossen sein. Öffnen Sie die Haube nur, wenn Sie dazu in der Gebrauchsanweisung angewiesen werden. Stützen Sie sich nicht auf die Arbeitsplattform, wenn sich der Roboterarm des Geräts bei geöffnetem Deckel bewegt, um die Ladeposition einzunehmen.

  • Page 167: Zentrifuge

    VORSICHT Beschädigung des Geräts Bewegen Sie das Z-Modul (Roboterarm) nach einem Stromausfall nicht manuell vor das Gerät. Beim Schließen der Haube des QIAcube Connect kann es zu Schäden kommen, wenn diese mit dem Z- Modul kollidiert. WARNUNG Gefahr von Personen- und Sachschäden Heben Sie den Zentrifugendeckel vorsichtig an.

  • Page 168: Gefahr Durch Hitze

    WARNUNG Gefahr von Personen- und Sachschäden Die Rotorschraube muss zur Sicherheit mit dem Rotorschlüssel angezogen werden, der zusammen mit dem QIAcube Connect geliefert wird. Sollte die Schraube nicht fest genug angezogen sein, kann sie sich während der Zentrifugation lösen. WARNUNG Gefahr durch UV-Strahlung Eine mechanische Verriegelung gewährleistet, dass die Haube während des Betriebs der UV-LED...

  • Page 169: Strahlensicherheit

    Beschädigung des Geräts Verwenden Sie keine Sprühflaschen, die Alkohol oder Desinfektionsmittel enthalten, um die Oberflächen des QIAcube Connect zu reinigen. Sprühflaschen dürfen nur zur Reinigung von Gegenständen benutzt werden, die zuvor von den Arbeitsplattformen entfernt wurden und wenn dies nach den lokalen Laborvorschriften zulässig ist.

  • Page 170: Symbole Auf Dem Qiacube Connect

    Symbole auf dem QIAcube Connect Symbol Location Description Neben dem Schüttler Gefährdung durch heiße Geräteteile – Die Temperatur des Schüttlers kann bis zu 70 °C (158 °F) erreichen. Nahe der Zentrifuge; nahe des Verletzungsgefahr durch mechanische Teile – Kontakt mit sich bewegenden Roboterarms Geräteteilen vermeiden.
  • Page 171 Unique Device Identifier (eindeutige Gerätekennung) Typenschild an der Geräterückseite Unique Device Identifier (UDI) als 2D-Barcode im Data Matrix-Format Typenschild an der Geräterückseite Internationale Artikelnummer (Global Trade Item Number) Typenschild an der Geräterückseite Seriennummer Typenschild an der Geräterückseite Katalognummer QIAcube Connect User Manual  |  12/2024...

  • Page 172: Appendix E - Qiacube Connect Recycling Card

    Appendix E – QIAcube Connect Recycling Card The QIAcube Connect Recycling Card can be downloaded from www.qiagen.com/QIAcube-Connect under the Resource section. QIAcube Connect User Manual  |  12/2024...
  • Page 173 QIAcube Connect User Manual  |  12/2024...
  • Page 174 QIAcube Connect User Manual  |  12/2024...

  • Page 175: Revision History

    Updated “Managing protocols” & “starting a protocol run” sections. Added information on how to upload, replace and delete Customer Icon to run report. HB-2594-008 May 2023 Updated statements in Section 6, Cleaning and Maintenance, and Section 6.7.1, UV run. QIAcube Connect User Manual  |  12/2024...
  • Page 176 Trademarks: QIAGEN ® , Sample to Insight ® , QIAcube ® , QIAsphere ® (QIAGEN Group); DNA- ExitusPlus™ (AppliChem); RNaseZap ® (Ambion, Inc.); Microsoft ® , Windows ® (Microsoft Corporation); Gigasept ® , Lysetol ® , Mikrozid ® (Schülke & Mayr GmbH); DECON- QUAT ® (Veltek Associates, Inc.).
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  • Page 180 Ordering www.qiagen.com/shop  |  Technical Support support.qiagen.com  |  Website www.qiagen.com...

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