Knauer Azura Assistant ASM 2.1L User Manual
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Knauer Azura Assistant ASM 2.1L User Manual

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Assistant ASM 2.1L
User Manual
V6815A
HPLC

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Summary of Contents for Knauer Azura Assistant ASM 2.1L

  • Page 1 Assistant ASM 2.1L User Manual V6815A HPLC...

  • Page 2: Table Of Contents

    Mounting a KNAUER Valve ........
  • Page 3 Execution ........... . KNAUER...
  • Page 4 SmartMix Mixer ..........KNAUER...
  • Page 5 Index ........... . IQ - Installation Qualification (Functional test)....KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 6: Intended Use

    Optional pump heads made of titan for bio-compatibility Valve Drive V 2.1S There is the valve drive V 2.1S 6V/12V/16V, whereby the addi- tional details refer to the ports of the valves. The valves fall into two categories: KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 7: Eluents

    The list of selected solvents was compiled based on research in the pertinent literature and is only a recommendation. If there is any doubt, contact the Technical Support of the manufacturer. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...
  • Page 8  Toluol  Dilute ammonia solu- tion  Dilute acetic acid (10-50%), at 25° C/77.0° F  Dilute sodium hydrox- ide (1M)  Water 1. valid for the specified temperature range KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 9: Device Overview

    Pump 4.1S with pressure transducer, with 10 ml pump head  Degasser DG 2.1S, analytical, 2-channel  Smartmix 350 A valve is mounted laterallly on the detector UVD 2.1L. An elu- ent tray is supplied with the compact HPLC system. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 10: Device Overview In The Asm 2.1L

    UV/Vis detector with variable wave- length 190 nm- 500 nm. Valve drive V 2.1S Valve drives 6V, 12V, 16V for manual valves Electrical valves Valves of the company VICI Valco Instruments Co.Inc. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 11: Detector In The Asm 2.1L

    Device Overview Device Comment  Manual valves KNAUER 2-position valves or multi- position valves  Valves of the company VICI Valco Instruments Co.Inc. Degasser DG 2.1S By using a degasser a more stable baseline can be obtained.. Detector in the ASM 2.1L The ASM 2.1L can be equipped with a detector.

  • Page 12: Pump In The Asm 2.1L

    The pump heads can be easily removed and replaced via four front-accessible screws by the user. Pump head Maximum pump capacity Stainless steel 10 ml Titanium 10 ml Stainless steel 50 ml Titanium 50 ml Ceramic 10 ml KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 13: Valve Drives In The Asm 2.1L

    Device Overview Valve Drives in the ASM 2.1L Prior to delivery the valve drive can be equipped with KNAUER multiposition valves and 2-position valves. Legend Valve Fig. 5 Valves in the ASM 2.1L  Usage 2-positon valves are mainly used for injections.

  • Page 14: 2-Position Valves

    2-position valves with 6p/2C and 6P/3C nels Multiposition Valves The multiposition valve is used in chromatography, for example in the following cases:  Selection of up to 16 different solvents  Fractioning KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 15: Degasser In The Asm 2.1L

    The ASM 2.1L can be equipped with a degasser. By using a degasser up to two eluents can be degassed simultaneously in a reliable and comfortable way. Legend Degasser Fig. 8 2-channel degasser in the ASM 2.1L KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 16: Smartmix Mixer

    Device Overview SmartMix Mixer The KNAUER SmartMix mixers are solvent mixers that are suit- able for high-performance liquid chromatography (HPLC). The liquids are mixed statically in the SmartMix mixer. Legend Blind plug Mixer lid Inlet to the pump Mixer housing...

  • Page 17: Scope Of Delivery

    Scope of Delivery Scope of Delivery Note Only use original parts and accessories made by KNAUER or a company authorized by KNAUER. Delivery ASM 2.1L with devices User manual german/english Power cable with kettle plug Azura Accessories kit Installation Qualification Document...

  • Page 18: Safety For Users

     Observe national and international regulations pertaining to laboratory work!  Original spare parts, tools, and eluents made or recommen- ded by KNAUER More safety-relevant information is listed in alphabetical order in the following table: Topic Explanations Decontamination...

  • Page 19: Definition Of Personal And Material Damages

    Category Explanations DANGER! Lethal or very serious injuries can occur. WARNING! Serious injuries can occur. CAUTION! Moderate injuries or device defects can occur. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 20: Symbols And Signs

    Grip the device at its sides near the middle when lifting or moving. Warning signs High-voltage hazard UV-light hazard Electrostatic-discharge hazard Leak hazard Mandatory signs Pull the power plug. Wear protective gloves. Observe torques. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 21: Unpacking And Setup

    You have various options to contact the technical support: Phone +49 30 809727-111 +49 30 8015010 E-mail support@knauer.net You can make your requests in English and German. Location Requirements CAUTION! Possible damage to the device due to overheating! Set up the device so that it is pro- tected against exposure to direct sunlight.

  • Page 22: Unpacking

    Use a level to check that the device stands horizontally. Connectors on the Rear Side CAUTION! Possible damage to the device caused by condensed water! Allow device to acclimate for 3 h, before it is taken into operation. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 23: Controlling With The Pin Header

    Connected to LAN within a network Controlling with the Pin Header CAUTION! Short-circuit hazard.  Turn off the device before connecting it to the pin header. Pull the power plug. Plug Connector Assignments KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...
  • Page 24 TTL input  Low active Secure switching threshold at least 10 mA After receiving a signal (short-circuit to ground) from an external device, an error message appears and the device stops. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 25: Integrator Output

    Integrator Output The integrator output sends measuring signals from the detec- tor.  non-bipolar  1 channel  0 – 5 V  DAC 16 bit  Scalable  Adjustable to offset KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 26: Initial Startup

    Mounting directly at the holding bracket VICI Valco valve drive Mounting by using the adapter plate at the holding bracket Flow cells KNAUER flow cells Mounting by using the adapter plate at the holding bracket Columns Axial compressible col- Mounting by using the adapter umns Vertex Plus AX ...

  • Page 27: Attaching The Holding Bracket To The Side Panel

    Fig. 14 Holding bracket is attached Result Holding bracket is attached Next steps Mount accessories like valves, flow cells or columns to the hold- ing bracket. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 28: Mounting A Knauer Valve

    2. Fasten the valve with two screws and two washers from the back side. Fig. 15 Front side of KNAUER valve at the holding bracket Fig. 16 Back side of KNAUER valve at the holding bracket Result The KNAUER valve is mounted.

  • Page 29: Mounting A Vici Valco Valve

    Fig. 17 Back side of VICI Valco valve at the holding bracket Fig. 18 Back side of VICI Valco valve at the holding bracket Result The VICI Valco valve is mounted. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 30: Mounting A Vici Valco Valve Drive

    Back side of VICI Valco valve drive at the holding bracket Fig. 20 Back side of VICI Valco valve drive at the holding bracket Result The VICI Valco valve drive is mounted. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 31: Mounting A Flow Cell

    2. Position the holder onto the bore holes of the holding bracket. 3. Tighten the screws and washers. Fig. 22 Column holder with hold- ing bracket Result Axially compressible column is mounted. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 32: Detector

    1. Using the wrench, unscrew and remove the threaded ring 2. Remove the cover and spacer . Put the spacer aside. 3. Insert the cover. 4. Using the wrench, tighten the threaded ring. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 33: Inserting The Flow Cell

    5. Push the slide into the detector 6. Tighten the knurled- head screws. Fig. 25 Assembling the flow cell Result Flow cell is assembled. Next steps Connecting the capillaries KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 34: Connecting The Capillaries

    Bleeding the Pump Before the pump can be used for analyses it has to be bleeded. That means air will be removed from pump head and capillaries. Prerequisite Capillary connections are connected. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 35: Connecting A 2-Position Valve

    Fig. 28 Connections for 2-posi- tion valve Application Examples for Valves  2-position valve 6P/3C Injection  Selection of a column  Backflushing of a column  Backflushing of a precolumn KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 36: 2-Position Valve 6P/3C

    Port 1: Sample injection Port 2: Sample loop Port 3: Column Port 4: Pump Port 5: Sample loop Port 6: Abfall Fig. 31 Valve position Inject Fig. 30 Valve position Load KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 37: Column Selection

    Legend Detector Column A Valve Column B Fig. 32 Column selection-Usage of Column A Note Make sure there is no pressure when switching so that the col- umns are not damaged. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 38: Backflushing Of A Column

    Detector Valve Column Fig. 34 Backflushing - Transport of the sample onto the col- Note Make sure there is no pressure when switching so that the col- umn is not damaged. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 39: Backflushing Of A Precolumn

    From the valve, the precolumn is filled with sample through the channel 2->3. From the channel 6->1, the quickly dissolved sub- stances on the column are seperated, the heavily retarding sub- stances remain into the precolumn. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 40: 2-Position Valve 6P/2C

    Fig. 38 Column selection with a 6P/2C valve Precleaning of a Sample by a Precolumn Basics The precleaning of a sample is used in chromatography, for example in the following cases: KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 41: Degasser

    The main column is switched into the flow system after the valve has been switched over. Now the sample will be transported to the main column by using a second solvent. Degasser Legend Degasser Fig. 40 Front view degasser KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 42: Connecting A Solvent Hose

    Shows that the vacuum is within the work range. Usually this indicator lights up when the vacuum has been gener- ated and stays on as long as the degasser is in use. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 43: Degasser Gas Outlet

    2. Connect the degasser with pump. 3. Connect the pump to the manual valve. 4. Connect the valve with column. 5. Connect the column to the detector. 6. Connect the detector to the waste bottle. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 44: Hpg System

    3. Connect the pumps with the mixer. 4. Connect the mixer with valve. 5. Connect the valve with column. 6. Connect the column to the detector. 7. Connect the detector to the waste bottle. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 45: Leak Management

    The leak management consists of the leak sensor and the drain- age system. The drainage system ensures that escaping liquids flow into a waste bottle. If there is to much liquid, the red LED KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 46: Connecting A Device To A Computer To A Local Area Network (Lan)

    Connecting a Device to a Computer to a Local Area Network (LAN) This chapter describes how to set up a local area network (LAN) and how a network administrator can integrate this LAN into a KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 47: Configuring The Lan Settings

    6. Check the settings in the tab General. The correct settings for the DHCP client are:  a) Obtain an IP address automatically b) Obtain DNS server address automatically 7. Click on the button OK. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 48: Connecting The Cables

    4. In the router configuration, check the IP-address range and make changes if necessary. Result Once the router has assigned IP addresses to all devices, the chromatography software can be used to remotely control the system. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 49: Integrating The Lan Into A Company Network

    The LAN connections between the modules and router are connected.  The LAN cable is connected to the workstation and router.  The chromatography software has been installed by KNAUER or a company authorized by KNAUER.  The capillaries in the solvent bottles have a filter insert. ...

  • Page 50: Startup Of The Device

    1 second. Result The device is ready for operation. If the test fails an error mes- sage will be displayed. Contact the technical support of KNAUER if the error occurs several times. Practical Tip Regularly check the capillaries for leaks.

  • Page 51: Operation With Chromatography Software Or Control Unit

    LEDs and switch on the front of the device The LEDs can have different colors depending on the operating conditions. Standby To activate the standby, keep the switch pressed for 5 seconds. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 52: Control With Chromatography Software

    You can control the device using the touchscreen on the mobile Control Unit. The Control Unit is an optional accessory. You will find a detailed description on the Control Unit in its accompany- ing user manual. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 53: Installation Qualification (Iq)

    Execution The test can carried out either by KNAUER's Technical Support or by a technical service authorized by KNAUER. The OQ documentation required for executing the OQ is with costs (once) and can be ordered separately from KNAUER.

  • Page 54: Troubleshooting

    2. Check all screw fittings. 3. Check whether air has gotten into the supply lines. 4. Check device for leaks. 5. Pay attention to system messages. Further measures Inform the Technical Support of KNAUER. Possible Problems and Rectifications Problem Solution Assistant...
  • Page 55  Exchange the check valves.  When the pump head seals are defective, solvent enters the piston backflushing. Inform the Technical Support of KNAUER.  Exchange the pump head.  Pressure and flow Pump without pressure sensor: Pay rate variations...

  • Page 56: System Messages

    System Messages If other system messages are displayed besides those listed below, please turn the device off and then on. Inform the Tech- nical Support of KNAUER in case the system message repeats itself. The system messages are sorted alphabetically.
  • Page 57 Switch the lamps on the device to Lamps are off "ON". Cannot read RTC Switch the device off and on. Inform the Technical Support of KNAUER in case the system message repeats itself.  Detector: calibra- Check lamp. tion failed ...
  • Page 58 Valve middle: failure Middle valve is stiff detected!  Drive is defective.  Valve right: failure Right valve is stiff detected!  Drive is defective. Wrong valve type Correct the settings. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 59: Maintenance And Care

    Proper maintenance of your HPLC device will ensure successful analyses and reproducible results. Maintenance Contract The following maintenance work on the device may only be per- formed by KNAUER or a company authorized by KNAUER and is covered by a separate maintenance contract:  Opening the device.

  • Page 60: Detector Uvd 2.1S

    2. Inject it into the inlet of the flow cell and allow it to act for 5 minutes. 3. Fill the syringe with water and inject again. 4. Remove the flow cell from the detector and use a nitrogen stream to dry it. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 61: Cleaning The Lens Of An Analytical Flow Cell

    6. Using the wrench, tighten the threaded ring. Result The lens is clean. Next steps If the cleaning does not have the desired effect, clean the light guide. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 62: Cleaning The Light Guide Of A Preparative Flow Cell

    1. Using the Allen wrench, loosen the threaded ring 2. Remove the cover and the spacer (not part of all flow cells). 3. Using the tweezers, pull out the compression bushing the light guide KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 63: Pump P 2.1S/P 4.1S

    Legend Capillary screw fit- ting Outlet screw fitting Inlet screw fitting Fastening screw Inlet screw fitting Outlet screw fitting Fig. 54 Screw fittings on the pump head KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 64: Replacing The Pump Head

    5. Hold the pump head by hand, and consecutively pull out all fastening screws. 6. Remove the pump head. Legend Inlet and outlet of the piston backflush- Fastening screw Inlet screw fitting Pressure transducer Fig. 55 Replacing the pump head KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 65: Installing The Pump Head

    1. Unscrew the inlet fitting 2 and capillary fitting 2. Unscrew the outlet fitting 1 3. Remove the check valve. 4. Unscrew the inlet fitting 1 5. Remove the check valve. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 66: Cleaning The Check Valves

    Removing the Valve During assembly, make sure the rotor seal is in the right position and installed properly, because otherwise there may be a mix- up of the channels or clogging may occur. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...
  • Page 67 3. Remove the rotor seal and deposit true sided. Mark the position and the installation position of the rotor seal. Fig. 60 Deposit the rotor seal true sided with the marking of the position. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...
  • Page 68 , several sealing disks Fig. 61 Inner components of the inside the valve. valve Note Pay attention to the alignment of the rotor seal in the valve during reassembly. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 69: Alignment Of The Rotor Seal In The Valve

    Position of the rotor seal in the multi- position valve 2-position valve 6P/2C Fig. 63 Position of the rotor seal in the 6P/2C valve 2-position valve 6P/3C Fig. 64 Position of the rotor seal in the 6P/3C valve KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 70: Exchanging The Vici Valve Head

    3. Connect the new valve to the drive. 4. Tighten the screw at the valve. Fig. 65 Mounted VICI Valve 5. Change settings on the Control Unit or in the software. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 71: Inserting A New Needle Seal

    In this case, the automatic pump control will switch the device off. Inform the technical support of KNAUER. SmartMix Mixer in the ASM 2.1L If the flow rate and the gradient composition become unstable, it may be due to a blockage of the mixing chamber.

  • Page 72: Opening The Smartmix Mixer

    Replacing the filter Process Figure system 1. Remove the filter system in the mixer lid with a pair of pointed twee- zers. Fig. 69 Remove the filter system from the mixer lid KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 73: Replacing The Cartridge

    Do not use any metal tools to take the cartridge out of the hous- ing. Otherwise, damage might be done to the seals of the car- tridge. 1. Take the PEEK sealing ring, lying on the cartridge, off the car- tridge. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...
  • Page 74 6. Put the mixer lid onto the mixer housing with the cartridge and the PEEK sealing ring. 7. Tighten the four screws on the mixer lid with an Allen wrench (wrench size 3.0 × 150). KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 75: Technical Data

    Flow rate maximum 10.0 ml/min Pressure drop 1.37 mm Hg/ml/min) Pressure resistance maximum 7 bar Dead volume approx. 285 μl per channel Wetted materials ® PEEK, glass-filled PTFE, Teflon AF KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 76: Detector Uvd 2.1S

    Flow rate accuracy ±1 % at 1 ml/min  For pumps without a pressure transducer dependent on pres- sure Flow rate precision Relative standard deviation RSD: < 0.5 % (1 ml/min) KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 77: Valve Drive V 2.1S

    Analytical version 0.5 - 2.0 ml/min < 5 ml/min Micro version 0.1 - 0.5 ml/min < 1.5 ml/min Cartridge Analytical cartridge 350 μl mixture volume Micro cartridge 100 μl mixture volume KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 78: Spare Parts And Accessories

    300 bar Analytical Layer thickness 10 mm A4061 Connection 1/16“ Inner diameter 1.1 mm Volume 10 μl Material Stainless steel with heat Max. flow rate exchanger Max. pressure 20 ml/min 300 bar KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...
  • Page 79 100 bar Preparative Layer thickness 0.5 /1.25 /2 mm A4068 Connection 1/4“ Inner diameter 4.0 mm Volume 160 μl Material Stainless steel Max. flow rate 10000 ml/min Max. pressure 200 bar KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 80: Pump Heads

    10 ml pump head, stainless steel A54123-1 10 ml pump head, titanium A54121-1 10 ml pump head, ceramics A54122 50 ml pump head, stainless steel A54133 50 ml pump head, titanium A54131 KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 81: Valves

    6 port, 1/16”, stainless steel A1373 6 port, 1/16”, PEEK A1374 6 port, 1/8”, stainless steel A1375 6 port, 1/8”, PEEK A1376 12 port, 1/8”, stainless steel A1378 16 port, 1/16”, stainless steel A1379 KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 82: Sample Loops For The Valve

    1/8”. Holding Bracket for Valves, Columns, and Flow Cells Name Order number Valves Holding bracket for KNAUER valve, com- A9853 plete Holding bracket for VICI Valco valves, A9853-1 completely with adapter plate...

  • Page 83: Mixer

    Spare Parts and Accessories Mixer Name Order num- SmartMix mixer 350 A5350 SmartMix mixer 100 A5351 Analytical cartridge (350 μl) A5356 Micro cartridge (100 μl) A5355 Filter set for SmartMix A0164-1 KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 84: Abbreviations And Terminology

    Comprehensive functionality test of individual components in a system (operation qualifica- tion) Port Connector on a valve Retarding A substance which has a delayed elution caused by an interaction with the column fill material. KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...
  • Page 85 Abbreviations and Terminology Term Explanations Router Module in computer network that checks data packets and forwards them. Solvents Mobile phase (eluent) or carrier for liquid chro- matography KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 86: Legal Information

    5. Packaging and transport damage In the event of device malfunctions, directly contact the manu- facturer. Manufacturer Wissenschaftliche Gerätebau Dr. Ing. Herbert KNAUER GmbH Hegauer Weg 38 14163 Berlin, Germany Phone: +49 30 809727-0 Fax: +49 30 8015010...

  • Page 87: Disposal

    (January, 2001), old devices manufactred by KNAUER are marked as waste electrical and electronic equipment: 160214 WEEE registration KNAUER as a company is registered by the WEEE number DE 34642789 in the German "ElektroAltgeräteRegister" (EAR). It belongs to category 8, under which fall all medical devices and laboratory equipment.

  • Page 88: Declaration Of Conformity

    Declaration of Conformity Manufacturer name Wissenschaftliche Gerätebau and address Dr. Ing. Herbert KNAUER GmbH Hegauer Weg 38 14163 Berlin, Germany ASM 2.1L Product number: EY The device complies with the following requirements and prod- uct specifications:  DIRECTIVE 2006/42/EC OF THE EUROPEAN PARLIAMENT...

  • Page 89: Table Of Figures

    Front side of KNAUER valve at the holding bracket ... . . 29 Fig. 20: Back side of KNAUER valve at the holding bracket ....29 Fig. 21: Back side of VICI Valco valve at the holding bracket .
  • Page 90 Insert new filter system in the mixer lid ..... . 75 KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 91: Index

    ‘Control Unit’ Setup Chromatography Software Troubleshooting Leak management Location Declarationf of conformity Decontamination Degasser Maintenance Detector Maintenance contract Rear panel Maintenance by users Disposal Mandatory signs Manufacturer Modifiers Neelde seal Installing KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...
  • Page 92 Spring strip Start IN Technical Support Terminology Test cell Test intervals Transportation damages UV light Valve 2-postion valve Dismounting Multiposition valve Types Valve drive Valve position Inject Load Warning signs Warranty KNAUER Assistant ASM 2.1L User Manual V6815A, version 1.2...

  • Page 93: Iq - Installation Qualification (Functional Test)

    Inventory number* Knauer product number Firmware version Location ClarityChrom® ☐ ChromGate® ☐ Application software Version number Place of installation Device manufacturer Wissenschaftlicher Gerätebau Dr. Ing. Herbert Knauer GmbH Hegauer Weg 38 14163 Berlin support@knauer.net Contact Name: Street: Postcode: City/Town: Telephone: E-mail:...
  • Page 94 Appendices ......................8 Comments ......................9 Rules on reproduction and duplication This document contains confidential information and may not be reproduced without the written consent of Wissenschaftlicher Gerätebau Dr. Ing. H. Knauer GmbH. KNAUER/13.08.2012/ ASM 2.1L /Rev1 IQ 2 / 9...

  • Page 95: Iq Certificate

    IQ for Knauer Devices IQ certificate The authorized Knauer agent will inspect the device and perform the necessary tests as described in the IQ document. All results are noted using a blue pen and confirmed with the date (DD-MM-YYYY) and signature.

  • Page 96: Objective

    Proper delivery and installation of the device will be documented. Instructions The IQ is carried out by an authorized Knauer agent in accordance with the instructions described below as well as the attached and approved report. Any deviations to the specifications and problems encountered during installation shall be recorded as comments at the end in the document ‘Installation Qualification...

  • Page 97: Shipkit, List Of Hardware And Software

    IQ for Knauer Devices Shipkit, list of hardware and software Quantity Device/accessory Order number Within the scope Comment of delivery (Yes/No) ASM 2.1L Shipkits of Modules Accessory Kit AZURA FZA02 Power cord ASM 2.1L Manual DE V6815 ASM 2.1L Manual EN V6815A IQ ASM 2.1L DE...

  • Page 98: Initial Startup

    IQ for Knauer Devices Initial startup Action Result Passed Comment Identify the device. The device is correct. Check transport No transport damage is damage. observed. Check the shipkit. The shipkit is complete. Connect the device to The device is connected.

  • Page 99: Installation Qualification - Deviations

    IQ for Knauer Devices Installation Qualification - Deviations Any deviations that occur must be recorded here. Ref. No Description of deviation Action Accepted/corrected Date and signature of both parties KNAUER/13.08.2012/ ASM 2.1L /Rev1 IQ 7 / 9...

  • Page 100: Appendices

    IQ for Knauer Devices Appendices Available Comment 1. Order confirmation 2. Delivery note 3. List of small and wear parts 4. Delivery logbook 5. Knauer maintenance and service - authorization 6. Other documents KNAUER/13.08.2012/ ASM 2.1L /Rev1 IQ 8 / 9...

  • Page 101: Comments

    IQ for Knauer Devices Comments Responsible person Name: (in block letters) Date: Signature: Authorized agent of customer Name: (in block letters) Date: Signature: KNAUER/13.08.2012/ ASM 2.1L /Rev1 IQ 9 / 9...
  • Page 102 © Wissenschaftliche Gerätebau Dr. Ing. Herbert Knauer GmbH All rights reserved. The information in this document is subject to change without prior notice. Translation of the original German edition of this manual, version 1.2. 2013-08-19 Printed in Germany on environmentally friendly paper from sustainable forests.

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