Guidelines For Multimode Source Settings In Mm-Es+Apci Mode - Agilent Technologies G1978B User Manual

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Guidelines for multimode source settings in MM-ES+APCI mode

Guidelines for multimode source settings in MM-ES+APCI mode

Drying gas flow
Nebulizer pressure
corona current to balance ESI and APCI. A higher nebulizer pressure results
in more ESI. A lower nebulizer pressure results in more APCI.
Drying gas temperature
control the drying and to be able to maintain the set point.
Vaporizer
MM-APCI. MM-ESI is usually unaffected except for sodium adduction. The
vaporizer will compensate for flow rate or solvent composition.
Capillary Voltage
setting of 2000 is a good compromise.
Corona current
current will reduce the ESI signal and increase the APCI signal.
Charging Voltage
The above set of parameters is provided as a starting point and should yield good response
N O T E
for many analytes. To obtain a specific response, i.e., high sensitivity detection of a
compound or class of compounds, or a balanced response to a wide variety of compound
classes, these parameters and the LC mobile phase composition should be examined
further using traditional techniques for optimizing a method.
52
Always set to 5 L/min (IR does the drying)
Start at 40 psi. You will use the nebulizer pressure and the
Set to 300°C. Remember you want the vaporizer to
Start at 200°C. A higher temperature usually works better for
Set to 2000 V. You are balancing ESI and APCI response. A
Set to 1 µA for positive or negative polarity. More corona
Set the charging voltage to 2000 V.
Multimode Source for 6410 Triple Quad LC/MS User Guide