Guidelines; Guidelines For Multimode Source Settings In Mm-Es Mode - Agilent Technologies G1978B User Manual

3 Reference

Guidelines

Guidelines

Guidelines for multimode source settings in MM-ES mode

Nebulizer pressure
Drying gas flow
Drying gas temperature
starting temperature is 250°C. If running a cold vaporizer temperature, then
set the drying gas temperature to vapor temperature or lower. If running the
vaporizer hot (>175°C), then set the drying gas temperature to 350°C.
Remember you want the vaporizer to control the drying and to be able to
maintain the set point.
Vaporizer
getting excessive sodium adducts, lower the temperature. You can run as low
as 60°C. It is recommend to run 100°C or greater. Negative ion TFA adducts
work best at lower temperature (<150°C).
Vcap
Charging Voltage
50
Always set to 60 psi.
Always set to 5 L/min (IR does the drying).
Depends on the vaporizer temperature. A good
Start at 150°C. ESI works across a broad vaporizer range. If you are
Set to 2000 V. High mass ions (>1000) prefer a higher Vcap.
Set to 200 V.
Multimode Source for 6410 Triple Quad LC/MS User Guide